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Meis1 protein plays key role in stopping cell division in the heart

UT Southwestern Medical Center scientists have discovered a protein that works with others during development to put the brakes on cell division in the heart, they report today in Nature.

23 Apr 2020

Study: Patients’ genetically edited stem cells successfully reversed diabetes in mice

Using induced pluripotent stem cells produced from the skin of a patient with a rare, genetic form of insulin-dependent diabetes called Wolfram syndrome, researchers transformed the human stem cells into insulin-producing cells and used the gene-editing tool CRISPR-Cas9 to correct a genetic defect that had caused the syndrome.

22 Apr 2020

Should age be a prioritizing factor in deciding who gets treated for COVID-19?

With pubic healthcare systems becoming increasingly strained due to the impact of COVID-19, healthcare professionals are having to question whether to factor age in as a priority when deciding who to treat.

22 Apr 2020

Immunity to coronavirus infection may help stem the pandemic

The raging coronavirus pandemic is causing immense fear and uncertainty across the world. One of the most distressing aspects of COVID-19 disease is the seemingly large number of unknowns. These include the burning question of immunity. Does a person who was sick with the COVID-19 and then recovered or was infected without symptoms, have immunity against re-infection?

21 Apr 2020

New study may offer a breakthrough in treating telomere diseases

Capping decades of research, a new study may offer a breakthrough in treating dyskeratosis congenita and other so-called telomere diseases, in which cells age prematurely.

21 Apr 2020

Landmark 30-year study describes clinical course of patients with Crigler-Najjar syndrome

A new study summarizes more than 30 years of clinical experience and describes the clinical course of 28 individuals homozygous for damaging mutations in the UGT1A1 gene who were born between 1984 and 2015 with Crigler-Najjar syndrome.

17 Apr 2020

Tumors commandeer cell death pathway to avoid immune system attack after radiation

Cancer cells avoid an immune system attack after radiation by commandeering a cell signaling pathway that helps dying cells avoid triggering an immune response, a new study led by UTSW scientists suggests.

13 Apr 2020

CRISPR may help in kidney-transplants by detecting viruses

An exciting new study published in the journal Nature Biomedical Engineering in April 2020 reports excellent results with a new test for two common viruses that infect kidney transplant patients. The levels of these viruses shoot up during the acute phase of rejection.

13 Apr 2020

UChicago Medicine launches clinical trial to explore plasma transfusions for COVID-19 patients

The University of Chicago Medicine is launching a clinical trial to study whether blood plasma from people who have recovered from COVID-19 can be used to treat patients who are still in the hospital with severe disease symptoms.

13 Apr 2020

New clinical trial launches to test efficacy of cell therapy for severe COVID-19 cases

After a lightening round of proposals and reviews, an international team of scientists led by Dr. Camillo Ricordi was granted immediate FDA authorization for a 24-patient clinical trial to test the safety and exploratory efficacy of umbilical cord-derived mesenchymal stem cells to block the life-threatening lung inflammation that accompanies severe cases of COVID-19.

11 Apr 2020

ERA-EDTA creates European database of dialysis, transplanted patients with COVID-19

The ERA-EDTA has created a European database that collects granular individual data of dialysis patients and transplanted patients with COVID-19.

9 Apr 2020

Using computer software to optimize treatment for diabetic kidney diseases

Diabetic kidney diseases are the main cause of kidney failure in industrialized countries. An international, EU-funded R&D project - which is being headed by the Medical University of Innsbruck, and involves collaboration with the Medical University of Vienna and international partners - is being implemented with the aim of using computer software to provide personalized predictions of the disease's progression and bring about improvements in individuals' responses to treatment.

9 Apr 2020

Researchers succeed in restoring mobility and sensation of touch in stroke-afflicted rats

Researchers at Lund University in Sweden have succeeded in restoring mobility and sensation of touch in stroke-afflicted rats by reprogramming human skin cells to become nerve cells, which were then transplanted into the rats' brains.

8 Apr 2020

USC scientists report wider benefits of well-known hangover drug

A well-known hangover drug not only helps soothe pounding headaches but also triggers profound changes that protect the liver, USC scientists report in new findings that could help prevent alcohol-related harm.

7 Apr 2020

USC researchers show wider benefits to drug used for hangovers

A well-known hangover drug not only helps soothe pounding headaches but also triggers profound changes that protect the liver.

7 Apr 2020

Analysis of causative protein genotype can help predict Alport syndrome severity

A Japanese research team has successfully developed a system to predict the severity of Alport syndrome, a serious hereditary kidney disease that occurs in about 1 out of 5,000 people in the US. Patients with Alport syndrome have abnormalities in the causative protein, type IV collagen, that often lead to chronic renal dysfunction requiring dialysis.

6 Apr 2020

UPV leads development of new mechanical ventilator for patients with COVID-19

The Universitat Politècnica de València has led the development of a new mechanical ventilator, ready for a quick industrial production. It would provide hospitals with these devices for treating COVID-19 patients.

3 Apr 2020

Majority of patients with mantle cell lymphoma may benefit from CAR T-cell therapy KTE-X19

A one-year follow-up study led by The University of Texas MD Anderson Cancer Center revealed a majority of patients with mantle cell lymphoma resistant to prior therapies may benefit from treatment with CD19-targeting chimeric antigen receptor (CAR) T-cell therapy.

1 Apr 2020

ERC awards grants to 158 European scientists to identify effective immunotherapy strategies for cancer

The European Research Council (ERC) has announced it will support Professor Thomas Blankenstein to the tune of €2.5 million over five years. This year the ERC is awarding Advanced Grants to a total of 158 scientists across Europe.

1 Apr 2020

Researchers say that NSAIDs, JAK inhibitors and TNF blockers are safe to use in COVID-19

Amid the coronavirus disease (COVID-19) pandemic, many theories have emerged about the disease and the treatments that can in supportive care. A recent theory emerged that suggests non-steroidal anti-inflammatory drugs (NSAIDs) might exacerbate the symptoms of the novel coronavirus. Now, a new study shows that there is no evidence for or against the use of NSAIDS, particularly ibuprofen, for patients with COVID-19.

1 Apr 2020

Transplant News and Research

Meis1 protein plays key role in stopping cell division in the heart

Study: Patients’ genetically edited stem cells successfully reversed diabetes in mice

Should age be a prioritizing factor in deciding who gets treated for COVID-19?

Immunity to coronavirus infection may help stem the pandemic

New study may offer a breakthrough in treating telomere diseases

Landmark 30-year study describes clinical course of patients with Crigler-Najjar syndrome

Tumors commandeer cell death pathway to avoid immune system attack after radiation

CRISPR may help in kidney-transplants by detecting viruses

UChicago Medicine launches clinical trial to explore plasma transfusions for COVID-19 patients

New clinical trial launches to test efficacy of cell therapy for severe COVID-19 cases

ERA-EDTA creates European database of dialysis, transplanted patients with COVID-19

Using computer software to optimize treatment for diabetic kidney diseases

Researchers succeed in restoring mobility and sensation of touch in stroke-afflicted rats

USC scientists report wider benefits of well-known hangover drug

USC researchers show wider benefits to drug used for hangovers

Analysis of causative protein genotype can help predict Alport syndrome severity

UPV leads development of new mechanical ventilator for patients with COVID-19

Majority of patients with mantle cell lymphoma may benefit from CAR T-cell therapy KTE-X19

ERC awards grants to 158 European scientists to identify effective immunotherapy strategies for cancer

Researchers say that NSAIDs, JAK inhibitors and TNF blockers are safe to use in COVID-19

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