Drug Discovery News and Research

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The drug discovery process begins with recognizing a disease or clinical condition in which there is a lack of adequate medical treatment. Once a potential drug has been identified, pre-clinical research can begin. This process includes several stages; the first of which involves identifying and validating the prospective drug’s target through assay development, high throughput screening, hit identification and finally, lead optimization. Once the pre-clinical process is complete, the newly synthesized drug candidate is selected for future clinical development.

IONTAS, Adaptate Biotherapeutics join forces to generate and optimize antibodies for novel cancer targets

IONTAS Limited, a leader in the discovery and optimization of fully human antibodies, today announced it has entered into a collaboration agreement with Adaptate Biotherapeutics, developers of antibody-based therapeutics for modulation of gamma delta T-cells.

From FairJourney Biologics 4 Dec 2019

Streamlining Immuno-Oncological Therapeutic Antibody Discovery

The growing trend of implementing immunotherapy into oncology has resulted in various new therapeutic cancer treatments utilizing antibodies.

From Sartorius 3 Dec 2019

Consortium launches ambitious project to transform the treatment of pain

In an effort to address the critical public health need for new, safer and more effective medicines to treat pain, a consortium based at the Laboratory of Systems Pharmacology at Harvard Medical School has launched an ambitious project titled STOP PAIN (Safe Therapeutic Options for Pain and Inflammation).

2 Dec 2019

One Nucleus reveals finalists of annual BioNewsRound Award

One Nucleus reveals the finalists of its annual BioNewsRound Award, recognizing life science companies that have announced exciting developments for patients and the sector. The finalists will present at Genesis 2019 where the winner will be announced.

29 Nov 2019

ICR scientists carry out first comprehensive assessment of chemical probe resources

A new report urges biomedical researchers to use online web resources very carefully, taking into account their complementary benefits and weaknesses, when selecting small-molecule chemical probes to help answer their research questions.

28 Nov 2019

Oligomerix and Feinstein Institutes publish preclinical data of Alzheimer's disease treatment

Oligomerix, Inc., a privately held company pioneering the development of tau oligomer inhibitors for Alzheimer's disease and related neurodegenerative disorders, and the Feinstein Institutes for Medical Research announced today the publication of preclinical data demonstrating that an oral small molecule drug inhibits the formation of neurotoxic tau oligomers in an animal model of tau aggregation most relevant to AD.

26 Nov 2019

Better definition could lead to better diagnosis, treatment for rare diseases

Thousands of rare diseases cumulatively affect millions of people across the globe, yet because each case is so rare doctors struggle to accurately diagnose and effectively treat individual patients. Every time a patient with an unspecified disorder walks into a new clinic or shows up in an emergency room, doctors must start from scratch. The patients often go through years of such experiences before they ever get a diagnosis.

26 Nov 2019

Novoheart collaborates with AstraZeneca to develop world’s first human heart-in-a-jar model of heart failure

Novoheart, a global stem cell biotechnology company, is pleased to announce a collaboration with global biopharmaceutical company AstraZeneca, in an effort to develop the world’s first human-specific in vitro, functional model of heart failure with preserved ejection fraction (HFpEF), a common condition especially among the elderly and in women, with the reported prevalence approaching 10% in women over the age of 80 years.

26 Nov 2019

University of Sheffield receives Queen's Anniversary Prize for innovation in neuroscience

Neuroscience research at the University of Sheffield has been recognized by Her Majesty The Queen for delivering real benefits in improving patient outcomes for people living with some of the most devastating neurodegenerative diseases.

22 Nov 2019

UTSA research aims to use sulfur to expedite new drug development

Organosulfur compounds are widely present in our bodies and the natural environment. They are found in onions, shallots and even cauliflower. Medical research finds that when consumed, they can protect against cancer, heart disease and even diabetes. There is also evidence of these compounds' antiviral and antibacterial uses. About a quarter of all pharmaceutical drugs currently use OSCs.

21 Nov 2019

Coriell Institute for Medical Research wins $7.7 million NINDS contract

Coriell Institute for Medical Research has been awarded a $7.7 million contract by the National Institute of Neurological Disorders and Stroke, part of the National Institutes of Health focused on the study of nervous system disorders.

21 Nov 2019

Researchers develop breakthrough in marine sponge cell culture

Vertebrate, insect, and plant cell lines are important tools for research in many disciplines, including human health, evolutionary and developmental biology, agriculture and toxicology. Cell lines have been established for many organisms, including freshwater and terrestrial invertebrates.

21 Nov 2019

CTF, DELopen jointly offer unique opportunities to neurofibromatosis research community

The Children's Tumor Foundation, an innovative and global neurofibromatosis (NF) research foundation announced today a collaboration with DELopen, a DNA-encoded library technology platform sponsored by WuXi AppTec, a leading global provider of R&D and manufacturing services enabling companies in the pharmaceutical, biotechnology and medical device industries.

19 Nov 2019

TARA's organ-on-a-chip technology can directly measure in vivo cardiac performance, study shows

TARA Biosystems, Inc. today reported in vivo and in vitro functional data from a study of investigational candidate, MYK-491, showing that TARA's human iPSC-derived organ-on-a-chip technology can directly measure in vivo cardiac performance.

18 Nov 2019

Neural architecture search automates the development of deep learning-based models for cancer research

Argonne researchers have created a neural architecture search that automates the development of deep-learning-based predictive models for cancer data.

18 Nov 2019

LUNAC announces spin out with £2.65 million funding to develop advanced anticoagulants

LUNAC Therapeutics today announced it has spun out of the University of Leeds with £2.65M funding in the first close of a Series A financing round.

15 Nov 2019

PhoreMost and Sentinel Oncology expand partnership to advance novel allosteric PLK1 inhibitor

PhoreMost Limited, the UK-based biopharmaceutical company dedicated to drugging ‘undruggable’ disease targets, and Sentinel Oncology, today announce an expansion of their collaboration to accelerate the progression of SOL686, a novel allosteric Polo-like kinase 1 (PLK1) inhibitor through preclinical development and IND enabling studies for the treatment of Glioma.

From PhoreMost 15 Nov 2019

TACC announces role as key collaborator in NIH grant to study chronic pain and opioid dependence

Pain impacts nearly every individual at some point in their lives. With more than 25 million adults in the U.S. experiencing daily pain, the U.S. is facing a crisis due to the high prevalence of chronic pain and associated opioid use disorder and overdose deaths.

14 Nov 2019

Dopamine D2 receptor modulates Wnt expression, controls cell proliferation

The dopamine D2 receptor has a previously unobserved role in modulating Wnt expression and control of cell proliferation, according to a new study from the George Washington University and the University of Pittsburgh.

14 Nov 2019

New computational model could help in the development of anti-cancer drugs

Researchers from the Faculty of Medicine and the Institute for Molecular Medicine at the University of Helsinki have developed a computational model, Combined Essentiality Scoring (CES) that enables accurate identification of essential genes in cancer cells for development of anti-cancer drugs.

14 Nov 2019

Drug Discovery News and Research

Further Reading

IONTAS, Adaptate Biotherapeutics join forces to generate and optimize antibodies for novel cancer targets

Streamlining Immuno-Oncological Therapeutic Antibody Discovery

Consortium launches ambitious project to transform the treatment of pain

One Nucleus reveals finalists of annual BioNewsRound Award

ICR scientists carry out first comprehensive assessment of chemical probe resources

Oligomerix and Feinstein Institutes publish preclinical data of Alzheimer's disease treatment

Better definition could lead to better diagnosis, treatment for rare diseases

Novoheart collaborates with AstraZeneca to develop world’s first human heart-in-a-jar model of heart failure

University of Sheffield receives Queen's Anniversary Prize for innovation in neuroscience

UTSA research aims to use sulfur to expedite new drug development

Coriell Institute for Medical Research wins $7.7 million NINDS contract

Researchers develop breakthrough in marine sponge cell culture

CTF, DELopen jointly offer unique opportunities to neurofibromatosis research community

TARA's organ-on-a-chip technology can directly measure in vivo cardiac performance, study shows

Neural architecture search automates the development of deep learning-based models for cancer research

LUNAC announces spin out with £2.65 million funding to develop advanced anticoagulants

PhoreMost and Sentinel Oncology expand partnership to advance novel allosteric PLK1 inhibitor

TACC announces role as key collaborator in NIH grant to study chronic pain and opioid dependence

Dopamine D2 receptor modulates Wnt expression, controls cell proliferation

New computational model could help in the development of anti-cancer drugs

eBook: Advancing neurodegenerative research with iPSC-derived microglia models eBook

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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