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Researchers crack genetic code of lung tissues to identify novel targets for treating IPF

Researchers cracked the complete genetic code of individual cells in healthy and diseased human lung tissues to find potential new molecular targets for diagnosing and treating the lethal lung disease Idiopathic Pulmonary Fibrosis (IPF).

8 Dec 2016

Scientists discover truncated p53 proteins that promote cancer growth and metastasis

Discovered in the 1970s, tumor suppressors are among the most important proteins in the body.

8 Dec 2016

New approach uses silicon-based photonic probe to deliver light deep within brain tissues

The ability to stimulate neural circuits with very high precision light to control cells -- optogenetics -- is key to exciting advances in the study and mapping of the living brain.

8 Dec 2016

Research reveals opposing role for SNAP23 protein in endocrine and exocrine pancreas

Movement of secretory molecules, such as hormones and digestive enzymes, out of the cell is known as exocytosis. This process is guided by SNARE proteins, which help the fusion of secretory vesicles with the plasma membrane.

8 Dec 2016

Researchers discover first toxin antitoxin system in biofilms

Bacterial resistance does not come just through adaptation to antibiotics, sometimes the bacteria simply go to sleep.

8 Dec 2016

Synthetic sgRNA for CRISPR genome editing

Chemically synthesized single guide RNA is the best way to do CRISPR genome editing. It is more pure than biological methods of creating guide RNAs, like in vitro transcription or plasmids. As a result, sgRNA leads to more consistency and higher quality.

8 Dec 2016

Stem cell-based risk scoring tool could predict AML patient’s response to standard treatment

Leukemia researchers at Princess Margaret Cancer Centre have developed a 17-gene signature derived from leukemia stem cells that can predict at diagnosis if patients with acute myeloid leukemia (AML) will respond to standard treatment.

8 Dec 2016

Researchers discover biological pathway that plays vital role in tumor development

An international team led by researchers from the Technion-Israel Institute of Technology's Rappaport Faculty of Medicine and the Technion Integrated Cancer Center has discovered a biological pathway that plays an important role in tumor development.

7 Dec 2016

Older women with metastatic breast cancer more likely to have genetic alterations in tumors

A University of North Carolina Lineberger Comprehensive Cancer Center-led analysis has found that women who are 65 years or older with metastatic breast cancer were more likely to have a cancer-linked genetic alterations in their tumors, and had a larger total number of genetic alterations, than younger patients overall.

7 Dec 2016

Investigational diabetes drug that impedes Parkinson's progression getting ready for human trials

A new investigational drug originally developed for type 2 diabetes is being readied for human clinical trials in search of the world's first treatment to impede the progression of Parkinson's disease following publication of research findings today in the journal Science Translational Medicine.

7 Dec 2016

Study shows involvement of lipid metabolism in tumour metastasis

A study headed by Salvador Aznar Benitah, ICREA researcher at the Institute for Research in Biomedicine, and published today in Nature identifies metastasis-initiating cells through a specific marker, namely the protein CD36.

7 Dec 2016

Cold Spring Harbor Laboratory Press publishes new book on key aspects of ciliary biology

Nearly every cell in the human body has one or more protrusive structures called cilia or flagella.

7 Dec 2016

New research reveals role of two genetic mutations in subset of acute myeloid leukemia

Two genetic mutations known to play a role in many solid cancers might also help explain why a subset of acute myeloid leukemia (AML) patients develop the disease, according to new research from The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute.

7 Dec 2016

Drones can safely transport blood products without affecting cellular integrity, study shows

In what is believed to be the first proof-of-concept study of its kind, Johns Hopkins researchers have determined that large bags of blood products, such as those transfused into patients every day, can maintain temperature and cellular integrity while transported by drones.

7 Dec 2016

New discovery paves way to development of biochemical test for diagnosing Parkinson's disease

Misfolded proteins associated with Parkinson's disease were detected in cerebrospinal fluid by scientists at McGovern Medical School at The University of Texas Health Science Center at Houston, paving the way to development of a biochemical test to diagnosis the disease.

7 Dec 2016

UCLA researchers discover how chronic inflammation increases prostate cancer risk

UCLA researchers have discovered a previously unrecognized type of progenitor cell that, though rare in most regions of the human prostate, is found in uncommonly high numbers in inflamed areas of the gland.

6 Dec 2016

Cedars-Sinai receives $7.3 million grant to test safety of novel cell-based therapy in treating PAH

Researchers from the Cedars-Sinai Heart Institute and the Cedars-Sinai Department of Medicine are expanding their ongoing evaluation of a novel cell-based therapeutic candidate into the area of pulmonary arterial hypertension (PAH).

6 Dec 2016

Signaling pathway in fat cells may provide key to better treatments for obesity, Penn research finds

A signaling pathway in fat cells may one day provide the key to better treatments for obesity, according to new research by scientists in the Perelman School of Medicine at the University of Pennsylvania.

6 Dec 2016

Researchers develop new microfluidic device to study brain inflammation

The blood-brain barrier is a network of specialized cells that surrounds the arteries and veins within the brain. It forms a unique gateway that both provides brain cells with the nutrients they require and protects them from potentially harmful compounds.

6 Dec 2016

Researchers develop new compound that can take down defenses in M. tuberculosis

Part of the reason tuberculosis-causing bacteria are so good at colonizing the human body is that they have defenses against the body's immune system.

6 Dec 2016

Laboratory News and Research

Researchers crack genetic code of lung tissues to identify novel targets for treating IPF

Scientists discover truncated p53 proteins that promote cancer growth and metastasis

New approach uses silicon-based photonic probe to deliver light deep within brain tissues

Research reveals opposing role for SNAP23 protein in endocrine and exocrine pancreas

Researchers discover first toxin antitoxin system in biofilms

Synthetic sgRNA for CRISPR genome editing

Stem cell-based risk scoring tool could predict AML patient’s response to standard treatment

Researchers discover biological pathway that plays vital role in tumor development

Older women with metastatic breast cancer more likely to have genetic alterations in tumors

Investigational diabetes drug that impedes Parkinson's progression getting ready for human trials

Study shows involvement of lipid metabolism in tumour metastasis

Cold Spring Harbor Laboratory Press publishes new book on key aspects of ciliary biology

New research reveals role of two genetic mutations in subset of acute myeloid leukemia

Drones can safely transport blood products without affecting cellular integrity, study shows

New discovery paves way to development of biochemical test for diagnosing Parkinson's disease

UCLA researchers discover how chronic inflammation increases prostate cancer risk

Cedars-Sinai receives $7.3 million grant to test safety of novel cell-based therapy in treating PAH

Signaling pathway in fat cells may provide key to better treatments for obesity, Penn research finds

Researchers develop new microfluidic device to study brain inflammation

Researchers develop new compound that can take down defenses in M. tuberculosis

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