Drug Discovery News and Research

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The drug discovery process begins with recognizing a disease or clinical condition in which there is a lack of adequate medical treatment. Once a potential drug has been identified, pre-clinical research can begin. This process includes several stages; the first of which involves identifying and validating the prospective drug’s target through assay development, high throughput screening, hit identification and finally, lead optimization. Once the pre-clinical process is complete, the newly synthesized drug candidate is selected for future clinical development.

PhoreMost and C4XD sign neurodegeneration drug discovery collaboration agreement

PhoreMost Limited, the UK-based biopharmaceutical company dedicated to drugging ‘undruggable’ disease targets, and C4X Discovery Holdings plc, a pioneering drug discovery company, today announced they have signed a neurodegeneration drug discovery collaboration agreement.

From PhoreMost 25 Jun 2019

Nanion launches HTS automated patch clamp platform

The SyncroPatch 384i is a giga-ohm seal HTS automated patch clamp platform designed for flexibility, ease-of-use and reliability.

From Nanion Technologies 25 Jun 2019

Researchers report new way for creating tracers used with medical imaging

In an advance for medical imaging, scientists from University of North Carolina Lineberger Comprehensive Cancer Center have discovered a method for creating radioactive tracers to better track pharmaceuticals in the body as well as image diseases, such as cancer, and other medical conditions.

21 Jun 2019

Suppressing amygdala molecule enables faster recovery from PTSD symptoms

Fight or flight, panic, trembling: Our brains are wired to ensure we respond instantly to fear. While that fear response may save our lives in the dangerous moment, at times people stay on high alert long after the threat has passed, and develop post-traumatic stress disorder.

20 Jun 2019

Scientists develop new class of drugs to treat hereditary kidney disease

Scientists from the University of Sheffield are part of an international collaboration to develop a new class of drugs to treat a common genetic kidney disease which is a major cause of kidney failure.

18 Jun 2019

Blood pressure drug appears to be helpful for people with Alzheimer's disease

Seeking new treatments to slow the progression of Alzheimer's disease, researchers found the blood pressure drug nilvadipine increased blood flow to the brain's memory and learning center among people with Alzheimer's disease without affecting other parts of the brain, according to new research in the American Heart Association's journal Hypertension.

17 Jun 2019

Harvard chemists achieve landmark in drug discovery with synthesis of potent anti-cancer agent

It's a feat three decades in the making: Harvard University chemists have achieved what a new paper calls a "landmark in drug discovery" with the total synthesis of halichondrin.

17 Jun 2019

Vitamin D metabolite may stop mechanism by which cancer cells become drug-resistant

What's good for our bones may also help stop cancer cells that develop resistance to multiple chemotherapy drugs.

14 Jun 2019

Researchers develop new 3D tissue imaging technique to study disease at cellular level

To diagnose and treat diseases like cancer, scientists and doctors must understand how cells respond to different medical conditions and treatments.

14 Jun 2019

New small drug-targeting molecules may improve cancer treatment

Researchers from the University of Notre Dame have developed small drug-targeting molecules that may be hundreds to thousands of times more effective at delivering potent drugs to desired sites of disease, including cancer.

14 Jun 2019

Berkeley Lights and Amyris collaborate to improve testing of microbial strains

Berkeley Lights, Inc., the leader in digital cell biology, and Amyris, Inc., a leader in the development and production of sustainable ingredients for the Health & Wellness, Clean Beauty, and Flavors & Fragrances markets, announced today that they have entered into a collaboration focused on improving the production of high-value, small molecule, natural products from Amyris' microbial strains.

From Bruker Cellular Analysis 12 Jun 2019

Boehringer Ingelheim and University of Dundee extend collaboration to develop new cancer medicines

Following the success of their ongoing alliance, Boehringer Ingelheim and the University of Dundee extend their collaboration to develop new medicines that target and destroy key cancer causing proteins.

12 Jun 2019

Chemists build rich collection of natural product-like macrocycles for drug discovery

Natural products, or their close derivatives, make some of our most potent medicines, among which macrocycles with their large carbon-rich ring systems are one class.

12 Jun 2019

Researchers find more effective way to treat drug-resistant cancers

Researchers at SMU's Center for Drug Discovery, Design and Delivery have succeeded in lab testing the use of chemotherapy with a specific protein inhibitor so that the chemotherapeutic is better absorbed by drug-resistant cancer cells without harming healthy cells.

10 Jun 2019

Alzheimer's Drug Discovery Foundation announces first round of awards of Diagnostics Accelerator initiative

The Alzheimer's Drug Discovery Foundation announced today the first group of researchers who will receive funding through its Diagnostics Accelerator, a new research program that aims to fast-track the development of diagnostic tools and biomarkers for Alzheimer's disease and related dementias.

31 May 2019

Study uncovers how simpler organisms manage recycling of incomplete proteins

Our cells' process for transforming genes into useful proteins works much like an automobile factory's assembly line; there are schematics, parts, workers, motors, quality control systems and even recycling crews.

31 May 2019

Newly identified internal regulator helps control body's response to fight infection

Scientists have identified a new internal regulator which helps control the body's response to fight infection.

30 May 2019

Children's Tumor Foundation establishes significant research initiative to combat NF2

On the occasion of World NF2 Awareness Day, the Children's Tumor Foundation has announced the establishment of a significant research initiative dedicated to finding effective treatments for NF2, along with a substantial investment of $2.3 million in this bold new effort.

23 May 2019

New fluorescent sensor can detect migrating cancer cells

A new fluorescent sensor developed by researchers from the University of Adelaide can detect migrating cancer cells and could be used to target medication to stop metastasis in aggressive cancers.

22 May 2019

Southern Research team aims to discover new, safer antimalarial medicines

Scientists at Southern Research's Drug Discovery division have joined the fight against malaria through efforts aimed at discovering new drugs and improving the safety and efficacy of current antimalarial medicines.

22 May 2019

Drug Discovery News and Research

Further Reading

PhoreMost and C4XD sign neurodegeneration drug discovery collaboration agreement

Nanion launches HTS automated patch clamp platform

Researchers report new way for creating tracers used with medical imaging

Suppressing amygdala molecule enables faster recovery from PTSD symptoms

Scientists develop new class of drugs to treat hereditary kidney disease

Blood pressure drug appears to be helpful for people with Alzheimer's disease

Harvard chemists achieve landmark in drug discovery with synthesis of potent anti-cancer agent

Vitamin D metabolite may stop mechanism by which cancer cells become drug-resistant

Researchers develop new 3D tissue imaging technique to study disease at cellular level

New small drug-targeting molecules may improve cancer treatment

Berkeley Lights and Amyris collaborate to improve testing of microbial strains

Boehringer Ingelheim and University of Dundee extend collaboration to develop new cancer medicines

Chemists build rich collection of natural product-like macrocycles for drug discovery

Researchers find more effective way to treat drug-resistant cancers

Alzheimer's Drug Discovery Foundation announces first round of awards of Diagnostics Accelerator initiative

Study uncovers how simpler organisms manage recycling of incomplete proteins

Newly identified internal regulator helps control body's response to fight infection

Children's Tumor Foundation establishes significant research initiative to combat NF2

New fluorescent sensor can detect migrating cancer cells

Southern Research team aims to discover new, safer antimalarial medicines

eBook: Advancing neurodegenerative research with iPSC-derived microglia models eBook

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