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UK’s first Centre for Phage Research highlights Actiphage in the KTN UK Phage Innovation Showcase

Tuberculosis is caused by a bacterium that has evolved to evade the body’s immune system; now, its natural enemy, a phage, is being used to detect the infection at an early stage.

18 May 2023

How the gut microbiome supports iron uptake by intestinal regulatory T-cells

Research paper discusses the relationship between iron deficiencies and immune tolerance in patients with inflammatory bowel disease. The study shows that high cellular iron levels fostered by pentanoate, a short-chain fatty acid produced by intestinal microbiota, are necessary for the homeostasis of regulatory T cells in the intestine, and iron deficiencies in Treg can result in lethal autoimmune disease.

17 May 2023

Study examines safety and efficacy of made-to-fade tattoos for medical markings

Researchers at Henry Ford Health -; one of the nation's leading integrated academic medical institutions -; in collaboration with Ephemeral Tattoo, have conducted a study on the safety and efficacy of made-to-fade tattoos for medical markings.

17 May 2023

Novel computational platform can expand the pool of cancer immunotherapy targets

Researchers at Children's Hospital of Philadelphia (CHOP) and the University of California, Los Angeles (UCLA) have developed a computational platform capable of discovering tumor antigens derived from alternative RNA splicing, expanding the pool of cancer immunotherapy targets.

17 May 2023

Study establishes a mechanistic link between obesity and oral cancer immune escape

A team from the University of Michigan Rogel Cancer Center and School of Dentistry, led by Yu Leo Lei, D.D.S., Ph.D., have identified a mechanism in mice for how obesity affects some oral cancers' ability to escape from the immune system.

16 May 2023

Mast cells play a crucial role in the development of chronic myeloid leukemia

Chronic myeloid leukemia (CML) is a type of blood cancer that arises from malignant changes in blood-forming cells of the bone marrow.

16 May 2023

Combination approach is safe, improves survival outcomes in a subset of glioblastoma patients

Intratumoral delivery of an engineered oncolytic virus (DNX-2401) targeting glioblastoma (GBM) cells combined with subsequent immunotherapy was safe and improved survival outcomes in a subset of patients with recurrent GBM, according to results from a multi-institutional Phase I/II clinical trial co-led by researchers at The University of Texas MD Anderson Cancer Center and the University of Toronto.

15 May 2023

Newly identified biomarker may predict NSCLC patients' treatment response to chemoimmunotherapy

Cutting-edge cancer treatments like immunotherapy are offering new hope for patients, often in combination with more common approaches such as chemotherapy. But determining the best treatment combination isn't always straightforward.

12 May 2023

Could personalized neoantigen vaccines prevent the recurrence of pancreatic cancer and increase patient survival?

Researchers conducted a phase I clinical trial of a personalized mRNA neoantigen vaccine.

12 May 2023

High-fat diets can promote atherosclerosis via gut bacteria interactions with the immune system

In a recent study, researchers determined that derivatives of natural emulsifiers such as phospholipids found in high-fat, high-cholesterol diets can promote atherosclerosis via gut bacteria interactions with the immune system.

11 May 2023

Fatty liver promotes the spread of colorectal cancer to the liver

Investigators at Cedars-Sinai Cancer found that fatty liver, a condition closely associated with obesity, promotes the spread of colorectal cancer to the liver.

11 May 2023

Research sheds light on the early cellular events that give rise to pancreatic cancer

Discussions of cancer often stress the genetic mutations that drive disease by altering the normal function of cellular proteins.

11 May 2023

New NIH program seeks to discover and catalog the breadth of somatic mosaicism in human tissues

The National Institutes of Health is launching a new program, the Common Fund's Somatic Mosaicism Across Human Tissues Network, that aims to transform our knowledge of how much genetic variation there is in the cells and tissues throughout our bodies.

11 May 2023

Adenovirus and mRNA COVID vaccines differ in 6-month antibody durability

Research compares the durability of neutralizing antibody responses among recipients of three different COVID-19 vaccines (BNT162b2, mRNA-1273, and Ad26.COV2.S) over a period of 6 months.

11 May 2023

COVID-19 infection may promote aortic aneurysms and new treatment may slow its growth

The intravenous delivery of immune-modulating cells may someday slow the expansion of bulges in the aorta, known as abdominal aortic aneurysms.

10 May 2023

Schlafen 12 identified as a novel HIV restriction factor

An international study led by MELIS-UPF researchers from the Infection Biology and Molecular Virology laboratories has identified and characterized Schlafen 12 (SLFN 12) as a novel HIV restriction factor.

10 May 2023

Menthol inhalation improves cognitive ability in animal models of Alzheimer's disease

Researchers from Cima University of Navarra (Spain) have shown in animal models of Alzheimer's disease that inhaling menthol improves cognitive ability.

10 May 2023

Air pollution exacerbates movement disorder after ischemic stroke

Air pollution has been shown to have a negative effect on the prognosis of ischemic stroke, or stroke caused by reduced blood flow to the brain, but the exact mechanism is unknown.

10 May 2023

Researchers map the immune system in the gut of kids with inflammatory bowel disease

Researchers from Karolinska Institutet and Sachs' Children and Youth Hospital in Sweden have mapped the immune system in the gut of children with inflammatory bowel disease (IBD).

9 May 2023

Boosting gut health with short-chain fatty acids

Research paper provides an overview of short-chain fatty acids (SCFAs) and their role in regulating gut homeostasis. It also discusses SCFA-producing bacteria and potential therapeutic approaches to boost SCFA levels in the gut to treat related diseases.

9 May 2023

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Immune System News and Research

UK’s first Centre for Phage Research highlights Actiphage in the KTN UK Phage Innovation Showcase

How the gut microbiome supports iron uptake by intestinal regulatory T-cells

Study examines safety and efficacy of made-to-fade tattoos for medical markings

Novel computational platform can expand the pool of cancer immunotherapy targets

Study establishes a mechanistic link between obesity and oral cancer immune escape

Mast cells play a crucial role in the development of chronic myeloid leukemia

Combination approach is safe, improves survival outcomes in a subset of glioblastoma patients

Newly identified biomarker may predict NSCLC patients' treatment response to chemoimmunotherapy

Could personalized neoantigen vaccines prevent the recurrence of pancreatic cancer and increase patient survival?

High-fat diets can promote atherosclerosis via gut bacteria interactions with the immune system

Fatty liver promotes the spread of colorectal cancer to the liver

Research sheds light on the early cellular events that give rise to pancreatic cancer

New NIH program seeks to discover and catalog the breadth of somatic mosaicism in human tissues

Adenovirus and mRNA COVID vaccines differ in 6-month antibody durability

COVID-19 infection may promote aortic aneurysms and new treatment may slow its growth

Schlafen 12 identified as a novel HIV restriction factor

Menthol inhalation improves cognitive ability in animal models of Alzheimer's disease

Air pollution exacerbates movement disorder after ischemic stroke

Researchers map the immune system in the gut of kids with inflammatory bowel disease

Boosting gut health with short-chain fatty acids

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