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Use of HIV RNA expression inhibitors restores immune function in HIV patients on cART

Immune activation and inflammation persist in the majority of treated HIV-infected individuals and is associated with excess risk of mortality and morbidity.

28 Aug 2018

Study uncovers mechanism that affects multiplication of dengue virus lineage

A lineage of type 1 dengue virus found in Brazil is able to prevail over another even though it multiplies less in vector mosquitoes and infected human cells.

15 Aug 2018

Researchers focus on uncoupling obesity from diabetes

About 422 million people around the world, including more than 30 million Americans, have diabetes. Approximately ninety percent of them have type 2 diabetes. People with this condition cannot effectively use insulin, a hormone made by the pancreas that helps the body turn blood sugar into energy.

15 Aug 2018

Scientists identify two potential new drug targets for treatment of HIV

Johns Hopkins scientists report they have identified two potential new drug targets for the treatment of HIV. The finding is from results of a small, preliminary study of 19 people infected with both HIV-;the virus that causes AIDS-;and the hepatitis C virus.

7 Aug 2018

Scientists create new tool to precisely control 3D architecture of linkages in drugs

When it comes to certain molecules, shape makes all the difference. The shape of limonene, for instance, a compound produced by citrus fruits, determines whether it tastes like orange juice or turpentine.

7 Aug 2018

Injecting vasoactive intestinal peptide into the eye enhances corneal graft survival

A new study in the American Journal of Pathology reports for the first time that injection of neuropeptide vasoactive intestinal peptide directly into the eye of mice enhanced corneal graft survival.

7 Aug 2018

Alcohol increases mortality in young mice infected with tuberculosis-causing bacterium

Alcohol increases the mortality of young but not old mice infected with the tuberculosis-causing bacterium Mycobacterium tuberculosis, and this effect is mediated by the production of a protein called interferon-alpha.

3 Aug 2018

CFDA accepts Ascletis’ NDA for first all-oral HCV treatment

Ascletis announced today it has received the acceptance letter from the China Food and Drug Administration for Ravidasvir new drug application.

1 Aug 2018

Researchers discover how chronic infections can outsmart the immune system

Like many chronic infections, visceral leishmaniasis thwarts the immune system's defenses so it can settle comfortably into its host.

1 Aug 2018

Genetic factors may play a role in progression of liver injury in Caucasians with hepatitis B infection

A new study has shown that genetic variation may increase the risk of severe liver damage in Caucasians with chronic hepatitis B infection.

27 Jul 2018

Nucleic acid nanoparticles found to have varying immune responses

An extensive experiment testing the immune effects of a broad group of lab-designed nucleic acid nanoparticles did not find a strong, uniform immune response, as had been predicted.

27 Jul 2018

Study shows bats co-opted genes from ancient ebola like virus million years ago

Some 18 million years ago, an ancestor of mouse-eared bats "stole" genetic material from an ancient virus related to Ebola.

25 Jul 2018

Scientists identify melanoma biomarkers that could help tailor immunotherapy treatments

Scientists at Dana-Farber/Brigham and Women's Cancer Center have identified biomarkers in melanoma that could help tailor immunotherapy treatments to maximize the benefits for patients while reducing the likelihood of severe side effects.

19 Jul 2018

Researchers describe key role of enzyme in regulating immune response against Chagas disease parasite

In an article published recently in the journal Nature Communications, researchers affiliated with the University of São Paulo in Brazil describe the central role played by an enzyme called phosphatidylinositol 3-kinase gamma in regulating the immune response against Trypanosoma cruzi, the protozoan parasite that causes Chagas disease.

16 Jul 2018

Study elucidates pathophysiology of systemic lupus erythematosus

Osaka University researchers elucidated the pathophysiology of systemic lupus erythematosus, an autoimmune disorder that causes inflammation and tissue damage.

11 Jul 2018

New small molecules offer promising new way to treat autoinflammatory diseases

EPFL scientists have discovered two small-molecule compound series that can effectively block a central pathway of the innate immune system, offering a promising new way for treating autoinflammatory diseases.

4 Jul 2018

Researchers discover immune cells that create and sustain chronic inflammatory bowel disease

In preclinical experiments, Laurie Harrington, Ph.D., and colleagues at the University of Alabama at Birmingham have discovered a subset of immune cells that create and sustain chronic inflammatory bowel disease.

27 Jun 2018

Scientists discover secret to success of antiviral gene

It's been known for years that humans and other mammals possess an antiviral gene called RSAD2 that prevents a remarkable range of viruses from multiplying.

25 Jun 2018

Altering bacteria’s genetic code may pave way for long-lasting drugs, shows study

By altering the genetic code in bacteria, researchers at The University of Texas at Austin have demonstrated a method to make therapeutic proteins more stable, an advance that would improve the drugs' effectiveness and convenience, leading to smaller and less frequent doses of medicine, lower health care costs and fewer side effects for patients with cancer and other diseases.

5 Jun 2018

Mayo discovery could enable development of personalized ovarian, brain cancer treatments

Mayo Clinic researchers have discovered that a molecular communication pathway – thought to be defective in cancer – is a key player in determining the effectiveness of measles virus oncolytic cancer treatment in ovarian and aggressive brain cancers.

17 May 2018

Interferon News and Research

Use of HIV RNA expression inhibitors restores immune function in HIV patients on cART

Study uncovers mechanism that affects multiplication of dengue virus lineage

Researchers focus on uncoupling obesity from diabetes

Scientists identify two potential new drug targets for treatment of HIV

Scientists create new tool to precisely control 3D architecture of linkages in drugs

Injecting vasoactive intestinal peptide into the eye enhances corneal graft survival

Alcohol increases mortality in young mice infected with tuberculosis-causing bacterium

CFDA accepts Ascletis’ NDA for first all-oral HCV treatment

Researchers discover how chronic infections can outsmart the immune system

Genetic factors may play a role in progression of liver injury in Caucasians with hepatitis B infection

Nucleic acid nanoparticles found to have varying immune responses

Study shows bats co-opted genes from ancient ebola like virus million years ago

Scientists identify melanoma biomarkers that could help tailor immunotherapy treatments

Researchers describe key role of enzyme in regulating immune response against Chagas disease parasite

Study elucidates pathophysiology of systemic lupus erythematosus

New small molecules offer promising new way to treat autoinflammatory diseases

Researchers discover immune cells that create and sustain chronic inflammatory bowel disease

Scientists discover secret to success of antiviral gene

Altering bacteria’s genetic code may pave way for long-lasting drugs, shows study

Mayo discovery could enable development of personalized ovarian, brain cancer treatments

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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