Drug Discovery News and Research

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The drug discovery process begins with recognizing a disease or clinical condition in which there is a lack of adequate medical treatment. Once a potential drug has been identified, pre-clinical research can begin. This process includes several stages; the first of which involves identifying and validating the prospective drug’s target through assay development, high throughput screening, hit identification and finally, lead optimization. Once the pre-clinical process is complete, the newly synthesized drug candidate is selected for future clinical development.

GARDP forms multi-actor partnerships to discover new antibiotics

Multi-actor partnership tests natural products and compound libraries for antibacterial activity Discovery efforts will focus on World Health Organization's priority pathogens The Global Antibiotic Research and Development Partnership is partnering with Calibr, the Helmholtz Centre for Infection Research, in particular its location Helmholtz-Institute for Pharmaceutical Research Saarland, and the University of Queensland's Community for Open Antimicrobial Drug Discovery in its efforts to develop and ensure new antibiotics are globally available to all patients who need them.

11 Apr 2019

Pittcon 2019 in Philadelphia proves successful

Pittcon 2019, the 70th annual conference and exposition for analytical chemistry and applied spectroscopy, saw an increase in attendance over last year’s Orlando event.

From Pittcon 11 Apr 2019

Bruker highlights innovative NMR capabilities and products at ENC 2019

At ENC 2019, Bruker highlights innovative NMR capabilities and products for biomolecular, materials research and pharmaceutical applications, as well as new scientific software solutions.

From Bruker BioSpin - NMR, EPR and Imaging 10 Apr 2019

Researchers aim to identify potential new drugs for wide range of diseases using AI

A half dozen University of Connecticut researchers are now working to identify potential new drugs to treat a wide range of diseases and conditions through a unique partnership that offers access to cutting-edge artificial intelligence technology and screening compounds at no cost.

10 Apr 2019

UTMB receives grant to combat highly-lethal hemorrhagic fever viruses

The University of Texas Medical Branch at Galveston, Profectus Biosciences, Vanderbilt University Medical Center, Mapp Biopharmaceutical and Genevant Sciences Corp. have been awarded up to $35 million to advance the development of rapid-acting vaccines and broad-spectrum treatments of the highly-lethal hemorrhagic fever viruses Ebola and Marburg.

9 Apr 2019

New clinical trials to investigate combination immunotherapy for treating advanced cancers

City of Hope physician-scientists recently opened two clinical trials to investigate a combination of cytokines and immunotherapy that may be able to transform nearly-impossible-to-treat cancer into a disease that can be corralled into remission.

8 Apr 2019

Immune cells key to predicting outcomes in cancer patients, study suggests

Scientists have identified key changes in immune cells within cancerous tumors that could help improve the development of treatments.

8 Apr 2019

Researchers create online tool to determine genetic diversity and ancestry of cell lines

Cancer is a highly varied disease, with genetic differences among different tumor types, individuals and ancestral populations. These genetic differences can impact disease aggressiveness, the type of disease, and the response to therapy.

5 Apr 2019

Expanding range and functionality of radiotracers for improved disease diagnosis

Biomedical imaging has revolutionized medicine, granting doctors a window into miniscule molecular and cellular processes inside the body. An EU-funded project helped to expand the view, developing innovative radiochemistry concepts and techniques that could lead to earlier diagnosis of diseases - saving lives.

4 Apr 2019

Researchers unravel 3D structure of key molecular target for cancer treatment

Columbia University scientists, in collaboration with researchers from Nimbus Therapeutics, have demystified a metabolic enzyme that could be the next major molecular target in cancer treatment.

4 Apr 2019

TTP's new spin-out Cellular Highways to commercialize advanced cell-sorting technology

TTP plc, a leading independent technology and product development company, has announced today the formation of Cellular Highways Ltd.

From TTP plc 4 Apr 2019

Researchers use metal-free catalyst to synthesize ketone from aldehyde

Ketones are important organic compounds found in a variety of pharmaceuticals, agrochemicals, and natural products.

4 Apr 2019

New technology could change the way gene editing is approached in future

Gene editing has been a much sought after and controversial technology. Last month, part of the World Health Organization called for an international registry to track all research into editing the human genome.

4 Apr 2019

Drug that looks at Alzheimer’s differently ready for its first in-human testing

Alzheimer's disease wreaks emotional havoc on patients, who are robbed of their memories, their dignity, and their lives.

4 Apr 2019

ADDF’s new initiative aims to advance digital tools for Alzheimer's and dementias

As part of its Diagnostics Accelerator research program, the Alzheimer's Drug Discovery Foundation announced today a new initiative that aims to fast-track the development of digital tools for Alzheimer's disease and related dementias.

4 Apr 2019

Metrion Biosciences announces closure of funding round

Metrion Biosciences Ltd, the specialist ion channel contract research and drug discovery company, announced today that it has completed a fully subscribed funding round on 14 March.

From Metrion Biosciences Limited 2 Apr 2019

Bruker acquires cloud-based scientific software provider Arxspan

Bruker Corporation today announced that it has acquired Arxspan LLC, a provider of cloud-based scientific software and workflow solutions, based in Southborough, Massachusetts.

From Bruker BioSpin - NMR, EPR and Imaging 30 Mar 2019

New approach to delivering school-based vaccines improves student's experience

Researchers at the University of Toronto and The Hospital for Sick Children (SickKids) have teamed up with educators, public health practitioners and grade seven students in Ontario to develop and implement a new approach to delivering school-based vaccines that improves student experience.

29 Mar 2019

Queen’s University Belfast and Domainex identify novel first-in-class FLIP inhibitors

Queen’s University Belfast and Domainex are pleased to announce that their joint project team has successfully identified novel first-in-class small molecule inhibitors of the anti-apoptotic protein FLIP.

29 Mar 2019

New short-pulse ultrasound technique enhances drug delivery to brains of mice

Scientists currently use long-wave pulses of ultrasound to deliver drugs, which can cause side effects. These new findings from Imperial on shorter-wave pulses could have implications for how drugs are used to help patients of Alzheimer's and other neurological diseases.

26 Mar 2019