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Cryo-electron microscopy helps analyze infection mechanisms of coronaviruses in detail

High-resolution cryo-electron microscopy and supercomputing have now made it possible to analyze in detail the infection mechanisms of coronaviruses. These viruses are notorious for attacking the respiratory tract of humans and animals.

27 Feb 2016

Novartis announces FDA approval of Afinitor for progressive, nonfunctional neuroendocrine tumors of GI

Novartis today announced that the United States Food and Drug Administration approved Afinitor (everolimus) tablets for the treatment of adult patients with progressive, well-differentiated, nonfunctional neuroendocrine tumors (NET) of gastrointestinal (GI) or lung origin that are unresectable, locally advanced or metastatic.

26 Feb 2016

Baxalta seeks FDA approval for ADYNOVATE to treat children with hemophilia A and for use in surgical settings

Baxalta Incorporated, a global biopharmaceutical leader dedicated to delivering transformative therapies to patients with orphan diseases and underserved conditions, announced today that it has submitted supplemental Biologics License Applications (sBLAs) to the U.S. Food and Drug Administration seeking approval for the use of ADYNOVATE [Antihemophilic Factor (Recombinant), PEGylated] to treat children under the age of 12 with hemophilia A and for use in surgical settings.

26 Feb 2016

Study reveals role of 'Kurly' protein found in cilia

A new study of a protein found in cilia - the hair-like projections on the cell surface - may help explain how genetic defects in cilia play a role in developmental abnormalities, kidney disease and a number of other disorders.

24 Feb 2016

New definitions and clinical criteria for sepsis, septic shock

Clifford S. Deutschman, MS, MD, vice chair of research in the Department of Pediatrics at Cohen Children's Medical Center and an investigator at The Feinstein Institute for Medical Research , presented new definitions and clinical criteria for sepsis and septic shock at the Society of Critical Care Medicine's 45th Critical Care Congress in Orlando, FL.

24 Feb 2016

UMMC surgeons develop a program to direct critically ill patients to appropriate treatment location

A team of surgeons at the University of Maryland Medical Center has developed a program that utilizes its Shock Trauma Center (STC) model to direct critically ill non-trauma patients to the appropriate treatment location and get them into an operating room and hospital intensive care unit (ICU) bed as quickly as possible.

24 Feb 2016

New study identifies cell communication mechanism

The cells of an organism interact not only with each other but with the extracellular matrix that surrounds them. Increasing evidence is unveiling the relevance of this structure--which is secreted by the cells themselves-- for the correct function of the organism and also for the development of various diseases.

24 Feb 2016

New computer program and electronic stethoscope developed to diagnose lung problems

The classic stethoscope has entered the digital age. Medical researchers have created a computer program that connects to an electronic stethoscope to classify lung sounds into five common diagnostic categories.

24 Feb 2016

New clinical trial focuses on respiratory drug ambroxol for treatment of Parkinson's disease

A medication approved to treat various respiratory diseases and that has demonstrated neuroprotective effects in preclinical studies is the focus of a new clinical trial for Parkinson's disease.

23 Feb 2016

ResMed announces definitive agreement to acquire Brightree

ResMed, the world's leading tech-driven medical device company and innovator in sleep-disordered breathing and respiratory care, today announced a definitive agreement to acquire privately held Brightree, a leader in business management and clinical software applications for the post-acute care industry.

From ResMed Corp 22 Feb 2016

CISCRP's first international AWARE for All event to be held in London

The Center for Information and Study on Clinical Research Participation is pleased to announce that its first international AWARE for All event will be held in the UK on 7 March, 2016 from 17:00 to 20:00 at London's Camden Centre on Euston Road.

22 Feb 2016

Excessive growth of bacteria in small intestine could lead to stunting in young children

Excessive growth of bacteria in the small intestine could be damaging the guts of young children, leading to stunting, scientists from the U.S. and Bangladesh have discovered.

22 Feb 2016

Air pollution exposure increases obesity risk

Laboratory rats who breathed Beijing's highly polluted air gained weight and experienced cardio-respiratory and metabolic dysfunctions after three to eight weeks of exposure.

22 Feb 2016

Mylan announces FDA's acceptance of ANDA filing for generic Advair Diskus

Mylan N.V. today announced that its abbreviated new drug application (ANDA) for fluticasone propionate 100, 250, 500 mcg and salmeterol 50 mcg inhalation powder has been accepted for filing by the U.S. Food and Drug Administration.

22 Feb 2016

Novartis receives FDA Breakthrough Therapy designation for PKC412 (midostaurin)

Novartis announced today that the United States Food and Drug Administration has granted Breakthrough Therapy designation to PKC412 (midostaurin). PKC412 (midostaurin) is an investigational treatment for adults with newly-diagnosed AML who are FLT3 mutation-positive, as detected by an FDA-approved test, and who are eligible to receive standard induction and consolidation chemotherapy.

19 Feb 2016

New treatment protects mice from MERS infection

In a new study, University of Maryland School of Medicine researchers have had promising results with a new treatment for Middle East Respiratory Syndrome (MERS). The study, published today in the journal Science Translational Medicine, found a new treatment that protected mice from MERS infection.

18 Feb 2016

Discovery could lead to more effective vaccines, personalised therapies for TB

Tuberculosis (TB) used to kill one in seven people around the world before the advent of antibiotics. However the increasing prevalence of multi-drug resistant TB means that doctors are running out of options in trying to combat this bacterium.

18 Feb 2016

Early life factors contribute to aging of lungs

Smoking mothers, respiratory infections and the date you were born contribute to determine how fast your lungs are aging.

17 Feb 2016

BD announces FDA clearance and European CE marking for new safety blood collection set

BD (Becton, Dickinson and Company), a leading global medical technology company, today announced the U.S. Food and Drug Administration (FDA) 510(k) clearance and European CE marking for a new safety blood collection set – the BD Vacutainer UltraTouch Push Button Blood Collection Set – that uses proprietary needle technology to help enhance the patient experience during this important procedure.

17 Feb 2016

WRAIR begins Phase 1 clinical trial to evaluate MERS vaccine candidate

The Walter Reed Army Institute of Research began vaccinations today in a Phase 1 clinical trial to evaluate the safety and immune response of a vaccine candidate to prevent Middle East Respiratory Syndrome (MERS).

17 Feb 2016

Respiratory News and Research

Cryo-electron microscopy helps analyze infection mechanisms of coronaviruses in detail

Novartis announces FDA approval of Afinitor for progressive, nonfunctional neuroendocrine tumors of GI

Baxalta seeks FDA approval for ADYNOVATE to treat children with hemophilia A and for use in surgical settings

Study reveals role of 'Kurly' protein found in cilia

New definitions and clinical criteria for sepsis, septic shock

UMMC surgeons develop a program to direct critically ill patients to appropriate treatment location

New study identifies cell communication mechanism

New computer program and electronic stethoscope developed to diagnose lung problems

New clinical trial focuses on respiratory drug ambroxol for treatment of Parkinson's disease

ResMed announces definitive agreement to acquire Brightree

CISCRP's first international AWARE for All event to be held in London

Excessive growth of bacteria in small intestine could lead to stunting in young children

Air pollution exposure increases obesity risk

Mylan announces FDA's acceptance of ANDA filing for generic Advair Diskus

Novartis receives FDA Breakthrough Therapy designation for PKC412 (midostaurin)

New treatment protects mice from MERS infection

Discovery could lead to more effective vaccines, personalised therapies for TB

Early life factors contribute to aging of lungs

BD announces FDA clearance and European CE marking for new safety blood collection set

WRAIR begins Phase 1 clinical trial to evaluate MERS vaccine candidate

How can microdialysis benefit drug development

Global and Local Efforts to Take Action Against Hepatitis

Addressing Important Cardiac Biology Questions with Shotgun Top-Down Proteomics

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