Drug Discovery News and Research

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The drug discovery process begins with recognizing a disease or clinical condition in which there is a lack of adequate medical treatment. Once a potential drug has been identified, pre-clinical research can begin. This process includes several stages; the first of which involves identifying and validating the prospective drug’s target through assay development, high throughput screening, hit identification and finally, lead optimization. Once the pre-clinical process is complete, the newly synthesized drug candidate is selected for future clinical development.

Breakthrough chromosome imaging could aid in development of new treatments

Chromosomes, each containing hundreds or thousands of genes, act like a detailed instruction manual for how cells should develop and behave.

28 Feb 2019

The Evolution of MDLC in the Pharmaceutical Industry

Dr Kelly Zhang outlines recent advances in multidimensional liquid chromatography (MDLC) for pharmaceutical analysis, to be discussed at Pittcon 2019.

From Pittcon 27 Feb 2019

Biophysicists visualize atomic-level dynamics of largest protein-degrading machine

Protein dynamics are essential for their functions. Protein nanomachines made of multiple protein molecules are highly dynamics during their actions on their functional targets, sometime called substrates.

26 Feb 2019

'Holy herb' (Yerba santa) identified as a potential treatment for Alzheimer’s disease

Yerba santa, also known as the ‘Holy Herb’, may have important implications for patients with Alzheimer’s disease.

22 Feb 2019

Successful testing of multi-organ "human-on-a-chip" could replace animals as test subjects

The replacement of animals as test subjects is one step closer to reality with the successful testing of multi-organ "human-on-a-chip" models to recapitulate the 28-day experiments typically used in animals to evaluate the systemic toxicity of drug and cosmetic compounds.

22 Feb 2019

Researchers use radio-telemetry to track the habitats of bottlenose dolphins

Using telemetry units in hospitals to monitor patient health is standard practice. Now, a similar approach is proving to be invaluable for dolphins, too.

22 Feb 2019

Discovery of potent compound in native California shrub may lead to treatment for Alzheimer's

The medicinal powers of aspirin, digitalis, and the anti-malarial artemisinin all come from plants. A Salk Institute discovery of a potent neuroprotective and anti-inflammatory chemical in a native California shrub may lead to a treatment for Alzheimer's disease based on a compound found in nature.

21 Feb 2019

Why melanoma tumors in the brain may be worse?

Melanoma tumors that have spread to the brain are equipped to thwart immunotherapies and targeted therapies that succeed against tumors growing in other sites.

20 Feb 2019

University of Dundee partners with Takeda to develop new treatments for tau pathology

The University of Dundee Drug Discovery Unit has announced a partnership with Takeda, Japan's largest pharmaceutical company, to develop possible new therapeutic treatments for tau pathology, an underlying feature in several forms of neurodegeneration, including Alzheimer's disease.

20 Feb 2019

Using light-based method for production of pharmaceutical molecules

Photoelectrochemical cells are widely studied for the conversion of solar energy into chemical fuels. They use photocathodes and photoanodes to "split" water into hydrogen and oxygen respectively.

18 Feb 2019

Cell membrane complexes may be new target for drugs to kill cancer cells

Old molecules and new complexes: researchers at Hollings Cancer Center at the Medical University of South Carolina have discovered cell membrane complexes called ceramidosomes that may be a new target for drugs to kill cancer cells.

13 Feb 2019

Researchers discover new therapeutic target for rare, aggressive pediatric cancers

Researchers at The University of Texas MD Anderson Cancer Center have discovered that malignant rhabdoid tumors, a rare pediatric cancer without effective treatments, may be sensitive to drugs that block the cancer cell's ability to dispose of misfolded proteins.

12 Feb 2019

Machine learning algorithm could accelerate the search for new drugs

Researchers have designed a machine learning algorithm for drug discovery which has been shown to be twice as efficient as the industry standard, which could accelerate the process of developing new treatments for disease.

12 Feb 2019

Researchers identify genes that make Staphyloccocus bacteria resistant to treatment

A Rutgers-led team has discovered two genes that make some strains of harmful Staphyloccocus bacteria resistant to treatment by copper, a potent and frequently used antibacterial agent.

11 Feb 2019

New research opens the way for tailored cancer drugs

New research on how cancer mutations influence a certain type of receptor on the cell membrane opens the way for the development of tailored drugs for certain cancers, such as rectal cancer and lung cancer.

11 Feb 2019

Researchers report promising advance in the search for new class of antidepressants

In experiments with mice, researchers at Johns Hopkins Medicine report a promising advance in the search for a new class of drugs to treat major depression.

8 Feb 2019

Amprologix wins £1.2 million contract to tackle antimicrobial-resistant MRSA

Amprologix Limited, a University of Plymouth spinout company, has won a £1.2 million contract from the Department for Health and Social Care to accelerate development and scale up its lead antibiotic candidate to tackle antimicrobial resistant MRSA and related superbugs.

4 Feb 2019

Tumor-fighting protein also promotes cancer growth, shows study

Search for a description of "p53" and it becomes clear that this human protein is widely known for its cancer-fighting benefits, leading to its renown as "the guardian of the genome."

1 Feb 2019

Insilico to present its latest results in AI for Drug Discovery on CXOTalk Show

Insilico Medicine, a Rockville-based company developing the end-to-end drug discovery pipeline utilizing the next generation artificial intelligence, will present its latest results in modern and next-generation AI for Drug Discovery on a live episode of the influential CXOTalk Show on February 8, 2019 at 1:00 PM Eastern time.

1 Feb 2019

Beckman Coulter Life Sciences announces acquisition of Labcyte

Beckman Coulter Life Sciences today announced its acquisition of Labcyte, a privately held, acoustic liquid handling company based in San Jose, California.

From Beckman Coulter Life Sciences - Automation and Genomics 31 Jan 2019

Drug Discovery News and Research

Further Reading

Breakthrough chromosome imaging could aid in development of new treatments

The Evolution of MDLC in the Pharmaceutical Industry

Biophysicists visualize atomic-level dynamics of largest protein-degrading machine

'Holy herb' (Yerba santa) identified as a potential treatment for Alzheimer’s disease

Successful testing of multi-organ "human-on-a-chip" could replace animals as test subjects

Researchers use radio-telemetry to track the habitats of bottlenose dolphins

Discovery of potent compound in native California shrub may lead to treatment for Alzheimer's

Why melanoma tumors in the brain may be worse?

University of Dundee partners with Takeda to develop new treatments for tau pathology

Using light-based method for production of pharmaceutical molecules

Cell membrane complexes may be new target for drugs to kill cancer cells

Researchers discover new therapeutic target for rare, aggressive pediatric cancers

Machine learning algorithm could accelerate the search for new drugs

Researchers identify genes that make Staphyloccocus bacteria resistant to treatment

New research opens the way for tailored cancer drugs

Researchers report promising advance in the search for new class of antidepressants

Amprologix wins £1.2 million contract to tackle antimicrobial-resistant MRSA

Tumor-fighting protein also promotes cancer growth, shows study

Insilico to present its latest results in AI for Drug Discovery on CXOTalk Show

Beckman Coulter Life Sciences announces acquisition of Labcyte

eBook: Essential guide to organoids in drug discovery eBook

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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