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New immunization approach may one day wipe out pneumonia, meningitis

A new vaccine allows pneumonia-causing bacteria to colonize inside the body, springing into action only if the bacteria pose a threat.

8 Jun 2016

First European fully superconductive coil reaching a magnetic field of 25 Tesla produced

Today, the magnets used in nuclear magnetic resonance (NMR) and medical magnetic resonance imaging (MRI) represent the primary commercial applications of superconductivity. NMR, used mainly in the chemical and pharmaceutical industry, allows discovering new molecules, studying the structure of proteins or analyzing food content. It is essential for drug development or the quality control of chemical compounds.

From Bruker BioSpin - NMR, EPR and Imaging 8 Jun 2016

Unsafe antiplatelet use persists in PCI patients

Contraindicated antiplatelet use is rare but persists in patients undergoing percutaneous coronary intervention, show US study data.

8 Jun 2016

Overtesting for HbA1C levels can increase risk of severe hypoglycemia

With a more-is-better mindset common in society, frequent commercials encouraging checks of glycated hemoglobin (HbA1C) levels, and ads for new diabetes medications to lower HbA1C in adults with Type 2 diabetes, Mayo Clinic researchers were not too surprised to find overtesting occurring.

7 Jun 2016

Coagadex now available for rare bleeding disorder patients in the UK

Bio Products Laboratory, Limited (BPL) today announced that Coagadex is now available for patients in the UK.

7 Jun 2016

New systems-based strategy may help accelerate TB drug discovery

The rise in multi-drug resistant (MDR) and extremely drug resistant (XDR) strains of Mycobacterium tuberculosis (MTB) is becoming a major cause of global health concern for treating tuberculosis, which affects a third of the global population.

7 Jun 2016

Disruptive sleep patterns could raise heart disease risk in shift workers and insomniacs

People who suffer from a lack of sleep and disordered sleep cycles could be increasing their chances of developing cardiovascular disease, according to a study in the American Heart Association’s Journal Hypertension.

7 Jun 2016

Study establishes copper’s role in fat metabolism

A new study is further burnishing copper's reputation as an essential nutrient for human physiology. A research team led by a scientist at the Department of Energy's Lawrence Berkeley National Laboratory and at the University of California, Berkeley, has found that copper plays a key role in metabolizing fat.

7 Jun 2016

HKUST study suggests innate immune response plays vital role in pathogenesis of AD

Alzheimer's disease (AD) is a devastating condition with no known effective treatment. The disease is characterized by memory loss as well as impaired locomotor ability, reasoning, and judgment. Emerging evidence suggests that the innate immune response plays a major role in the pathogenesis of AD.

7 Jun 2016

Researchers find increased cancer incidence among patients with primary immunodeficiency disorders

Primary immunodeficiency disorders are a group of more than 300 single gene defects that affect the role of the immune system and prevent it from functioning properly. When Roswell Park Cancer Institute researchers evaluated the overall and site-specific incidence of cancer among patients registered in the United States Immune Deficiency Network, they found increased cancer incidence rates among patients with primary immunodeficiency diseases — and, in particular, a significant increase in lymphoma cases.

7 Jun 2016

Bacteriophage combinations show therapeutic potential in reducing C. difficile infections

A new University of Leicester study has confirmed the therapeutic potential of bacteriophage combinations to treat highly infectious bacteria C. difficile infections (CDI) while retaining a healthy gut.

6 Jun 2016

Scientists find tiny organisms in upper female reproductive tract once thought to be sterile

They're inside our gut, on the skin, and in the mouth. Thousands of different types of micro-organisms live in and on the body, playing helpful roles in digestion or in aiding the body's natural defense system.

6 Jun 2016

Metformin along with chemotherapy/radiation improves outcomes in head and neck cancer patients

Researchers at the University of Cincinnati College of Medicine have found that adding increasing doses of an approved Type 2 diabetes drug, metformin, to a chemotherapy and radiation treatment regimen in head and neck cancer patients is not well tolerated if escalated too quickly, but allowing slower escalation could be beneficial.

6 Jun 2016

Study finds link between stress hormone and stage of schizophrenia

JCU Associate Professor Zoltan Sarnyai said it was the first meta-analysis study to compare the level of cortisol in a waking patient's body with the stage of schizophrenia they are suffering.

6 Jun 2016

Autoimmune diseases among lung cancer patients may make them unsuitable for immunotherapy

A significant proportion of lung cancer patients also have autoimmune disease, which may make them unsuitable for increasingly popular immunotherapy treatments, a team of researchers at UT Southwestern Medical Center's Harold C. Simmons Comprehensive Cancer Center has found.

6 Jun 2016

Scientists use new technique to repair fibrotic liver cells within the organ

Advances in stem cell research have made it possible to convert patients' skin cells into heart cells, kidney cells, liver cells and more in the lab dish, giving researchers hope that one day such cells could replace organ transplantation for patients with organ failure.

3 Jun 2016

Stimulating STING pathway to provoke life-extending immune response shows promise in AML

A protein known as STING plays a crucial role in the immune system's ability to "sense" cancer by recognizing and responding to DNA from tumor cells. Injection of compounds that activate the STING pathway directly into solid tumors in mice has been shown in prior studies to result in very potent anti-tumor immune responses.

3 Jun 2016

Immunotherapy with experimental monoclonal antibody could reduce neuroblastoma tumors

Neuroblastoma tumors shrank, some dramatically, in 80 percent of newly diagnosed, young, high-risk patients enrolled in a Phase II clinical trial that included an experimental monoclonal antibody. The immunotherapy agent was produced on the St. Jude Children's Research Hospital campus where the study is still underway.

3 Jun 2016

New mouse model allows researchers to evaluate CD40-antibody drugs effectively

Cancer immunotherapies--drugs that work by making a patient's immune system better at spotting and destroying tumor cells--are increasingly generating headlines. A number of these drugs are now being used for the treatment of melanoma, lung, and kidney cancers, and are showing promise in clinical trials with other diseases as well.

3 Jun 2016

Fluctuations in tRNA may play vital role in cancer metastasis

At any given moment, the human genome spells out thousands of genetic words telling our cells which proteins to make. Each word is read by a molecule known as a tRNA.

3 Jun 2016

Laboratory News and Research

New immunization approach may one day wipe out pneumonia, meningitis

First European fully superconductive coil reaching a magnetic field of 25 Tesla produced

Unsafe antiplatelet use persists in PCI patients

Overtesting for HbA1C levels can increase risk of severe hypoglycemia

Coagadex now available for rare bleeding disorder patients in the UK

New systems-based strategy may help accelerate TB drug discovery

Disruptive sleep patterns could raise heart disease risk in shift workers and insomniacs

Study establishes copper’s role in fat metabolism

HKUST study suggests innate immune response plays vital role in pathogenesis of AD

Researchers find increased cancer incidence among patients with primary immunodeficiency disorders

Bacteriophage combinations show therapeutic potential in reducing C. difficile infections

Scientists find tiny organisms in upper female reproductive tract once thought to be sterile

Metformin along with chemotherapy/radiation improves outcomes in head and neck cancer patients

Study finds link between stress hormone and stage of schizophrenia

Autoimmune diseases among lung cancer patients may make them unsuitable for immunotherapy

Scientists use new technique to repair fibrotic liver cells within the organ

Stimulating STING pathway to provoke life-extending immune response shows promise in AML

Immunotherapy with experimental monoclonal antibody could reduce neuroblastoma tumors

New mouse model allows researchers to evaluate CD40-antibody drugs effectively

Fluctuations in tRNA may play vital role in cancer metastasis

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