Immune System News and Research

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Experimental mRNA vaccine plus an immunotherapy reduced the likelihood of melanoma recurrence

The combination of an experimental mRNA vaccine with an immunotherapy reduced the likelihood of melanoma recurring or causing death by 44% when compared to immunotherapy alone, a new clinical trial shows.

17 Apr 2023

Maternal psychosocial stress may impact the developing infant gut microbiome

Researchers determined the impact of the psychosocial stress experienced by the mother on the gut microbiome of the infant.

15 Apr 2023

Uncovering the connection between the microbiome and aging

Researchers evaluated the recent advances in understanding how the microbiome influences aging and associated diseases.

15 Apr 2023

B cells use mechanical force to pull antigen molecules off other cells

Most cells evolve slowly, accumulating incremental changes that better suit their environments. Immune cells, because they must adapt rapidly to counter new threats, evolve much more quickly.

13 Apr 2023

AI-designed T-cell vaccine extremely effective at preventing severe COVID-19 in mice

The current COVID-19 vaccines are designed to trigger an antibody response to the SARS-CoV-2 spike protein, which is vulnerable to mutations that could make the vaccine less effective over time.

13 Apr 2023

Genomic study reveals Babesia duncani's pathogenicity and virulence

'Tis the season for hiking now that spring has arrived and temperatures are on the upswing. But with hikes come insect bites and on the increase in North America is babesiosis, a malaria-like disease spread especially between May and October by a tick.

13 Apr 2023

How to combat and lessen seasonal allergy symptoms

Welcoming spring this year has been bittersweet for the millions of allergy sufferers already experiencing itchy eyes, nasal congestion, sneezing and runny noses.

13 Apr 2023

MHRA research evaluates two different approaches to cancer therapies

The report 'Antibody conjugates for targeted delivery of Toll-like receptor 9 agonist to the tumor tissue', published in the PLOS ONE journal, highlights MHRA research which showed that genetic engineering of antibodies used to activate and support the immune system against cancer leads to improvements in their reliability and effectiveness.

13 Apr 2023

New tool provides insight into the developmental history of certain immune cells

A new tool that can uncover the developmental history of certain immune cells is now freely available worldwide. The tool provides insights into the stages that immune cells go through in a healthy individual and how this can be impacted in disease.

13 Apr 2023

From Sanger Sequencing to the Human Genome Project: The Evolution of DNA Sequencing Technology

In this inspiring interview, we speak to Dr. Radoje Drmanac, co-founder of Complete Genomics, about the past, present, and future of genomics research.

From MGI 13 Apr 2023

Early-life gut microbial dysbiosis exacerbates colitis

A recent Research journal study investigated the role of microbiota linked to the anaerobic plasmalogen biosynthetic pathway in establishing intestinal homeostasis. The study hypothesized that the presence of pls [PlsA/R]-positive bacterial species and plasmalogen bestow valuable intestine homeostasis in early life.

13 Apr 2023

Pragmatica-Lung Study aims to increase accessibility to cancer clinical trials

The National Cancer Institute, part of the National Institutes of Health (NIH), has helped launch a phase 3 randomized clinical trial (NCT05633602) of a two-drug combination to treat patients with advanced non-small cell lung cancer (NSCLC).

12 Apr 2023

New organoid platform could make vaccine screening quicker and greatly reduce animal testing

Developing and testing new treatments or vaccines for humans almost always requires animal trials, but these experiments can sometimes take years to complete and can raise ethical concerns about the animals' treatment.

12 Apr 2023

New insights into how Omicron variants avoid destruction by "killer" T cells

Omicron subvariants of SARS-CoV-2 -; the virus behind COVID-19 -; have shown an uncanny knack for evading antibodies produced either by vaccines or exposure to earlier versions of the virus, leading to many breakthrough infections.

11 Apr 2023

Mutant Salmonella strains cause more severe infections than wild-type bacteria in chickens

In Brazil, a group of researchers supported by FAPESP created mutant forms of Salmonella to understand the mechanisms that favor colonization of the intestinal tract of chickens by these pathogenic bacteria and find better ways to combat the infection they cause.

11 Apr 2023

Study expands the knowledge about gut viral diversity in healthy infants

Viruses are usually associated with illness. But our bodies are full of both bacteria and viruses that constantly proliferate and interact with each other in our gastrointestinal tract.

11 Apr 2023

Vulvovaginitis and the microbiome: a review of the diagnosis and treatment of acute and recurrent infection

Researchers explored the relationship between microbiome and vulvovaginitis.

11 Apr 2023

Study examines whether alcohol-associated burn injuries impair cognitive function

The relationship between alcohol use and burn injuries is a negative one in multiple ways. Not only are about 50% of adults who sustain burn injuries intoxicated at the time of injury, suggesting that alcohol use may have contributed to the incident, but alcohol use among burn-injured patients is associated with more severe complications, delayed recovery, and increased morbidity and mortality.

10 Apr 2023

Immune checkpoint inhibitor treatment is facilitated by dietary tryptophan metabolite synthesized by Lactobacillus reuteri

Researchers highlight how dietary tryptophan metabolite released by intratumoral Lactobacillus reuteri facilitates immune checkpoint inhibitor treatment.

10 Apr 2023

COVID mRNA vaccines fall short in eliciting lung resident memory T cells compared to natural infection

Pieren, D. K. J., Kuguel, S. G., Rosado, J., Robles, A. G., Rey-Cano, J., Mancebo, C., Esperalba, J., Falcó, V., Buzón, M. J., & Genescà, M. (2023). Limited induction of polyfunctional lung-resident memory T cells against SARS-CoV-2 by mRNA vaccination compared to infection. Nature Communications, 14(1). https://doi.org/10.1038/s41467-023-37559-w, https://www.nature.com/articles/s41467-023-37559-w

10 Apr 2023

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Immune System News and Research

Experimental mRNA vaccine plus an immunotherapy reduced the likelihood of melanoma recurrence

Maternal psychosocial stress may impact the developing infant gut microbiome

Uncovering the connection between the microbiome and aging

B cells use mechanical force to pull antigen molecules off other cells

AI-designed T-cell vaccine extremely effective at preventing severe COVID-19 in mice

Genomic study reveals Babesia duncani's pathogenicity and virulence

How to combat and lessen seasonal allergy symptoms

MHRA research evaluates two different approaches to cancer therapies

New tool provides insight into the developmental history of certain immune cells

From Sanger Sequencing to the Human Genome Project: The Evolution of DNA Sequencing Technology

Early-life gut microbial dysbiosis exacerbates colitis

Pragmatica-Lung Study aims to increase accessibility to cancer clinical trials

New organoid platform could make vaccine screening quicker and greatly reduce animal testing

New insights into how Omicron variants avoid destruction by "killer" T cells

Mutant Salmonella strains cause more severe infections than wild-type bacteria in chickens

Study expands the knowledge about gut viral diversity in healthy infants

Vulvovaginitis and the microbiome: a review of the diagnosis and treatment of acute and recurrent infection

Study examines whether alcohol-associated burn injuries impair cognitive function

Immune checkpoint inhibitor treatment is facilitated by dietary tryptophan metabolite synthesized by Lactobacillus reuteri

COVID mRNA vaccines fall short in eliciting lung resident memory T cells compared to natural infection

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