Drug Discovery News and Research

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The drug discovery process begins with recognizing a disease or clinical condition in which there is a lack of adequate medical treatment. Once a potential drug has been identified, pre-clinical research can begin. This process includes several stages; the first of which involves identifying and validating the prospective drug’s target through assay development, high throughput screening, hit identification and finally, lead optimization. Once the pre-clinical process is complete, the newly synthesized drug candidate is selected for future clinical development.

Bioengineering scientists propose new paradigm for research into cardiovascular diseases

Thrombosis-on-a-chip, vasculature-on-a-chip and engineered models of human cardiac fibrosis are just a few of the new technologies revolutionizing research into human cardiovascular disease--a condition responsible for 17 million deaths per annum globally.

25 Oct 2018

New partnership aims to tackle cancer health disparities

Although cancer affects all populations in the United States, certain ethnic populations bear a disproportionate burden of cancer compared with other groups, according to the National Cancer Institute.

23 Oct 2018

IDT to demonstrate CRISPR expertise at European-focused events

As an advocate for the genomics age, Integrated DNA Technologies (IDT), will showcase its renowned CRISPR expertise at a series of European-focused events.

From Integrated DNA Technologies 22 Oct 2018

Exelixis presents CABOSUN and METEOR trial results in patients with advanced renal cell carcinoma

Exelixis, Inc. today announced results from two analyses evaluating the effect of PD-L1 expression or prior treatment with immune checkpoint inhibitors on the efficacy of cabozantinib in patients with advanced renal cell carcinoma (RCC). The findings are being presented this week at the European Society for Medical Oncology 2018 Congress being held October 19-23 in Munich, Germany.

22 Oct 2018

Newly discovered compound shows potential for treating Parkinson's disease

A joint research group centered around Professor Hideyuki Okano and Associate Professor Jun Kohyama, Department of Physiology of the Keio University School of Medicine, together with a research group of Eisai Co., Ltd. has identified a compound that has the potential to be a treatment for Parkinson's disease by using dopaminergic neurons differentiated from induced pluripotent stem (iPS) cells from patients with familial Parkinson's disease.

19 Oct 2018

Key insights into the application, production of bioactive materials

Anatomy, Modeling and Biomaterial Fabrication for Dental and Maxillofacial Applications provides readers with information about dental implants and biomaterial fabrication for maxillofacial procedures and dental bone / tissue repair.

19 Oct 2018

Mice study shows antibiotics are not always necessary to cure sepsis

Biochemists, microbiologists, drug discovery experts and infectious disease doctors have teamed up in a new study that shows antibiotics are not always necessary to cure sepsis in mice.

17 Oct 2018

New findings reveal potential cellular players in tumor microenvironment

New findings presented today by CytoReason reveals possible new cellular players in the tumor microenvironment that could impact the treatment process for the most in-need patients - those who have already failed to respond to ipilimumab (anti-CTLA4) immunotherapy.

16 Oct 2018

Purdue researchers develop new chemical process to find better drug 'fits' for patients

When a medication doesn't "fit" the body quite right, the results can be devastating. Such is the case for thalidomide, which was prescribed in the 1950s and 1960s as a sedative or hypnotic, even for pregnant women.

16 Oct 2018

Sugar, a “sweet” tool to understand brain injuries

Australian researchers have developed ground-breaking new technology which could prove crucial in treating brain injuries and have multiple other applications, including testing the success of cancer therapies.

14 Oct 2018

Fat tissue could be a source of diabetes, shows new research

A new study by Australian researchers, out today, is challenging what we know about the causes of diabetes. The new research points to fat tissue as a source of disease, and widens our understanding beyond the traditional focus on liver and pancreas as the main culprits.

12 Oct 2018

Insilico to present advances in artificial intelligence at the Healthcare Innovation Summit Africa 2018

Insilico Medicine, a Rockville-based leader in next-generation artificial intelligence for drug discovery, biomarker development, and aging research, is pleased to announce the talk of its Head of Africa Artificial Intelligence for Healthcare Initiative, Iraneus Ogu, who will present alongside other academic thought leaders and industry experts at the 4th Healthcare Innovation Summit Africa 2018, one of the largest healthcare events in Africa.

12 Oct 2018

Rapid inactivation of MRSA superbugs using a simple LED array

Purdue University researchers are testing whether a light-active version of heme, the molecule responsible for transporting oxygen in blood circulation, may help people infected with MRSA.

12 Oct 2018

Top journal publishes special issue on deep learning for drug discovery and biomarker development

While the many concepts in artificial intelligence date back to the 20th century, the revolution in deep learning started around 2014-2015 when AI systems started outperforming humans in many tasks ranging from video games and image recognition to autonomous driving.

11 Oct 2018

Researchers unravel fresh clues as to how kidney stones form

Kidney stones--solid, pebble-like grit that forms when too much of certain minerals like calcium are in the urine--can strike men, women, and increasingly, children, and the presence and pain of stones afflicts more than 12 percent of the world's population.

11 Oct 2018

Bridge-like structure within estrogen receptor could serve as new drug target for breast cancer

Many breast cancer drugs block estrogen receptors inside cancer cells. Blocking the receptors early in disease progression staves off metastasis.

10 Oct 2018

Antibody Screening Tools; Improving Workflows

Antibody screening tools have exponentially increased the rate that candidates can be screened, multiplexing will increase processing to thousands per hour.¬

From Sartorius 9 Oct 2018

National Institutes of Health supports novel drug discovery research

Approximately $1.7 million in new funding from the National Institutes of Health will enable a multidisciplinary team of University of Illinois at Chicago researchers to build a reference library of bacteria to help scientists quickly identify bacterial strains and analyze their disease-fighting potential.

5 Oct 2018

New ReFRAME drug repurposing collection offers hope for treating major diseases

Each year, millions of people worldwide suffer from potentially fatal infectious diseases that often leave survivors facing a lifetime of related health problems. But what if drugs against such diseases already existed but nobody knew it?

4 Oct 2018

A Single Platform to Sequence All Monoclonal Antibody Proteins

Having a single platform to sequence all monoclonal antibody proteins provides researchers with key information for research, development and drug discovery

From Rapid Novor Inc 3 Oct 2018