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Penn Medicine researchers show that DNA editing errors can lead to cancer

Sometimes when the immune system makes small mistakes, the body amplifies its response in a big way: Editing errors in the DNA of developing T and B cells can cause blood cancers. Now, researchers from the Perelman School of Medicine, University of Pennsylvania have shown that when the enzyme key to cutting and pasting segments of DNA hits so-called "off-target" spots on a chromosome, the development of immune cells can lead to cancer in animal models.

11 Sep 2015

Researchers find key cellular enzyme that could be effective drug target for urologic cancer cells

Researchers at the SUNY Upstate Medical University have found that a key cellular enzyme, c-Abl, could be an effective drug target in cancer cells for urologic cancers, such as prostate and kidney.

11 Sep 2015

Luteolin may reduce risk of breast cancer in some women, find MU researchers

More than 100 women die from breast cancer every day in the United States. The odds increase in postmenopausal women who have taken a combined estrogen and progestin hormone replacement therapy; these women also have an increased risk of developing progestin-accelerated breast tumors.

11 Sep 2015

Research: Cancer preventative surgery may not be necessary in the future

Surgery to remove the breasts of women at increased risk of developing breast cancer may not be necessary in the future, according to research published in EBioMedicine. Two new studies looking at the effect the menstrual cycle has on the development of breast and ovarian cancer reveal alternative prevention strategies that may render surgery unnecessary.

11 Sep 2015

Study reveals why long-term use of L-DOPA leads to dyskinesia

Researchers have discovered why long-term use of L-DOPA (levodopa), the most effective treatment for Parkinson's disease, commonly leads to a movement problem called dyskinesia, a side effect that can be as debilitating as Parkinson's disease itself.

11 Sep 2015

Envision inaugurates 10th Annual Conference, honors outstanding achievements in low vision rehabilitation

Envision, the Wichita, Kan.-based not-for-profit organization that supports those who are blind and visually impaired, officially opened its 10th Annual Conference at The Grand Hyatt in downtown Denver this morning with a session honoring outstanding commitment to improving the quality of life of those who are blind and visually impaired and keynote addresses from two individuals representing the great athletic accomplishments those with vision loss can achieve.

11 Sep 2015

EMBL researchers use mass spectrometry data to analyze effects of cancer drugs

Researchers at EMBL's European Bioinformatics Institute (EMBL-EBI) have developed a new method for studying the targets and effects of cancer drugs using data from discovery mass spectrometry (MS) experiments.

11 Sep 2015

ACR releases two new publications to improve treatment of polymyalgia rheumatica, gout

The American College of Rheumatology (ACR) has released two new publications - recommendations aimed at improving the treatment of patients with polymyalgia rheumatica (PMR), and new classification criteria for gout.

10 Sep 2015

Masayo Takahashi awarded inaugural Ogawa-Yamanaka Stem Cell Prize

The Gladstone Institutes is pleased to present the inaugural Ogawa-Yamanaka Stem Cell Prize to Masayo Takahashi, MD, PhD, a faculty member and project leader in the Laboratory for Retinal Regeneration at the RIKEN Centre for Developmental Biology in Japan.

10 Sep 2015

Nicotine reinforcement demonstrated in study with ‘never-smokers’

In a study with 18 adults who had never smoked, scientists at Johns Hopkins report they have demonstrated one of the earliest steps — nicotine “reinforcement” — in the process of addiction, and shown that some people are far more vulnerable to nicotine addiction than others.

10 Sep 2015

A new approach to prevent breast and ovarian cancer

Surgery to remove the breasts of women at increased risk of developing breast cancer may not be necessary in the future, according to research published in EBioMedicine.

10 Sep 2015

Study points to genetic/metabolic factors that make people vulnerable to nicotine addiction

In a study with 18 adults who had never smoked, scientists at Johns Hopkins report they have demonstrated one of the earliest steps — nicotine "reinforcement" — in the process of addiction, and shown that some people are far more vulnerable to nicotine addiction than others.

10 Sep 2015

Worldwide Protein Data Bank symposium focuses on multi-scale structural biology

The symposium titled with "Integrative Structural Biology with Hybrid Methods" is held focusing on the multi-scale structural biology, which aims to analyze structures of protein molecules and their assemblies, cellular machines, organelle, and even living cells and organisms by the hybrid methods, integrating many different technologies, such as chemical cross-links, MS spectrometry, FRET, Super-resolution microscopy, X-ray diffraction, NMR, and Computer modeling, in addition to Cryo-electron microscopy that has been attracting much attention these days.

10 Sep 2015

Research opens up potential new pathways to vaccine development against HA-MRSA

New research led by NYU Langone Medical Center has uncovered why a particular strain of Staphylococcus aureus -- known as HA-MRSA -- becomes more deadly than other variations. These new findings open up possible new pathways to vaccine development against this bacterium, which the Centers for Disease Control and Preventions says accounts for over 10,000 deaths annually, mostly among hospital patients.

10 Sep 2015

HUCBC-derived monocytes diminishes Aβ pathology, improves cognition in AD modeled mice

Alzheimer's disease (AD), which affects an estimated 26 million people worldwide, is the fourth leading cause of death among the elderly and the leading cause of dementia. Predictions are that the number of AD cases will quadruple by 2050.

9 Sep 2015

Nutrition science must change to feed exploding world population, say international researchers

An international team of researchers, including scientists at the Virginia Bioinformatics Institute at Virginia Tech, said nutrition science will have to change drastically to feed an exploding world population.

9 Sep 2015

New UC Davis study suggests that popular molecular tests over-diagnose C. difficile infections

Clostridium difficile is a common cause of infection and diarrhea in hospitalized patients, but a new study by UC Davis pathologists suggests that many patients are mistakenly diagnosed and do not need antibiotic treatment. As a result, patients are likely being over-diagnosed and over-treated, adding to concerns about antibiotic resistance, damage to the "good" bacteria that live in people's intestines, and increased health-care costs.

9 Sep 2015

Dietary uptake of microRNAs certainly insufficient to affect physiological functions, reveal ETH biologists

The scientific world was astonished when, in 2011, Chinese researchers claimed to have found evidence suggesting that minute fragments of plant genetic material - so-called microRNA molecules - of rice ingested from food could play a role in regulating physiological processes in the human body. If this is indeed true, it might even be possible to deliberately modify human physiological functions via this route, for instance by incorporating microRNAs into novel functional foods.

9 Sep 2015

Penns' Abramson Cancer Center rated as 'exceptional' by NCI

The University of Pennsylvania's Abramson Cancer Center (ACC) has received an "exceptional" rating by the National Cancer Institute during an extensive peer-review process for its five-year competitive research support grant. The rating is the highest possible for an NCI cancer center.

9 Sep 2015

UCSF researchers lead $10 million research project on pediatric cancer

Researchers at UC San Francisco are leading a five-year, $10 million research project dedicated to pediatric cancer, funded by the first grant of its kind to focus on a molecular pathway that underlies many cancers rather than on a cancer in a particular organ or tissue in the body.

9 Sep 2015

Laboratory News and Research

Penn Medicine researchers show that DNA editing errors can lead to cancer

Researchers find key cellular enzyme that could be effective drug target for urologic cancer cells

Luteolin may reduce risk of breast cancer in some women, find MU researchers

Research: Cancer preventative surgery may not be necessary in the future

Study reveals why long-term use of L-DOPA leads to dyskinesia

Envision inaugurates 10th Annual Conference, honors outstanding achievements in low vision rehabilitation

EMBL researchers use mass spectrometry data to analyze effects of cancer drugs

ACR releases two new publications to improve treatment of polymyalgia rheumatica, gout

Masayo Takahashi awarded inaugural Ogawa-Yamanaka Stem Cell Prize

Nicotine reinforcement demonstrated in study with ‘never-smokers’

A new approach to prevent breast and ovarian cancer

Study points to genetic/metabolic factors that make people vulnerable to nicotine addiction

Worldwide Protein Data Bank symposium focuses on multi-scale structural biology

Research opens up potential new pathways to vaccine development against HA-MRSA

HUCBC-derived monocytes diminishes Aβ pathology, improves cognition in AD modeled mice

Nutrition science must change to feed exploding world population, say international researchers

New UC Davis study suggests that popular molecular tests over-diagnose C. difficile infections

Dietary uptake of microRNAs certainly insufficient to affect physiological functions, reveal ETH biologists

Penns' Abramson Cancer Center rated as 'exceptional' by NCI

UCSF researchers lead $10 million research project on pediatric cancer

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Deciphering the Microbiome with The Microsetta Initiative

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