Drug Discovery News and Research

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The drug discovery process begins with recognizing a disease or clinical condition in which there is a lack of adequate medical treatment. Once a potential drug has been identified, pre-clinical research can begin. This process includes several stages; the first of which involves identifying and validating the prospective drug’s target through assay development, high throughput screening, hit identification and finally, lead optimization. Once the pre-clinical process is complete, the newly synthesized drug candidate is selected for future clinical development.

New project aims to increase patient willingness to take life-saving oral drugs

A new collaboration grant to scientists from Discovery BioMed, Inc. and the Monell Center will support development of next-generation screening technologies to enable identification of bitter taste blockers.

14 Sep 2018

New research on molecular mechanistic understanding of drug delivery and drug delivery systems

Today, Insilico Medicine, Inc., a Rockville-based next-generation artificial intelligence company specializing in the application of deep learning for target identification, drug discovery and aging research announces the publication of a new research paper "Entangled Conditional Adversarial Autoencoder for de-novo Drug Discovery" in Molecular Pharmaceutics, the leading American Chemical Society journal covering research on the molecular mechanistic understanding of drug delivery and drug delivery systems

12 Sep 2018

Researchers design new medicine to treat highly aggressive pancreatic cancer

A treatment for highly aggressive and commonly fatal pancreatic cancer is being developed, reports a University of Houston researcher who has designed a new medicine that can inhibit two of the major pathways of the deadly disease.

12 Sep 2018

Discovery of unusual biosynthetic pathways could aid in the search for new natural products

Bacteria are master engineers of small, biologically useful molecules. A new study in Nature Communications has revealed one of the tricks of this microbial trade: synthesizing and then later inserting a nitrogen-nitrogen bond, like a prefabricated part, into a larger molecule.

12 Sep 2018

Improve reliability, accuracy of drug discovery process with new 3D cell analysis technology

Olympus Corporation today announced the U.S.-only launch of a new 3D cell analysis technology with ability to accurately analyze 3D cell cultures down to the nuclei, improving the reliability and accuracy of the entire drug discovery process, from compound selection to animal experimentation and clinical trials in humans.

From Evident Corporation - Life Sciences 11 Sep 2018

Barrow Institute initiates $50 million effort to seek cure for glioblastoma

Barrow Neurological Institute has initiated a $50 million effort, supported by the single largest research grant in the history of brain tumor research, to seek a cure for the deadliest form of brain cancer.

11 Sep 2018

BioIVT announces research into mechanisms involved in cholestatic drug-induced liver injury

BioIVT, a leading provider of research models and services for drug development, today announced its research into the mechanisms involved in cholestatic drug-induced liver injury has been published in Applied In Vitro Toxicology.

10 Sep 2018

NCCN updates Clinical Practice Guidelines to include new recommendations for CABOMETYX tablets

Exelixis, Inc. today announced that the National Comprehensive Cancer Network updated its Clinical Practice Guidelines to include new recommendations for CABOMETYX tablets.

7 Sep 2018

Meet Axol Bioscience at 2018 Cambridge International Stem Cell Symposium

We are very pleased to support the 6th Cambridge International Stem Cell Symposium from 19 - 21 September. The annual event held by the University of Cambridge will bring together more than 400 delegates, from students to professors, to discuss the biggest fundamental and translational questions as well as celebrate the great advances being made in stem cell biology all around the world.

From Axol Bioscience Ltd 7 Sep 2018

Biophysicists propose new way to identify crucial factors for protein folding

A protein's folding patterns help them perform their dedicated tasks. As the real "doers" of the cell, even a tiny alteration in a protein's amino acid backbone can cause misfolding and hinder the protein's functionality or cause disease.

5 Sep 2018

Vertex, Genomics team up to improve discovery of precision medicines

Vertex Pharmaceuticals Incorporated (Nasdaq: VRTX) and Genomics plc today announced a three-year collaboration, extendable to five years, to use human genetics and machine learning to improve discovery of targets for precision medicines, and to advance understanding of the clinical impact of human genetic variation and patient stratification in diseases with significant unmet need.

30 Aug 2018

Hesperos receives SBIR grant to create ‘human-on-a-chip’ model to mimic Alzheimer's disease

Hesperos, Inc., announced today the receipt of a NIH Phase I Small Business Innovation Research grant from the National Institutes of Health National Institute on Aging to help create a new multi-organ "human-on-a-chip" model that can realistically mimic the biology of Alzheimer's Disease and the effects of potential new therapies under realistic human physiological conditions.

29 Aug 2018

Researchers uncover why some cancers grow faster than others

University of Toronto researchers have uncovered why some cancers grow faster than others. The team led by Liliana Attisano, Professor in U of T's Donnelly Centre for Cellular and Biomolecular Research, has identified a protein called NUAK2, which is produced by cancer cells to boost their proliferation and whose presence in tumors is associated with poor disease prognosis.

29 Aug 2018

A non-canonical approach may improve radiation treatment for cancer

Although the success or failure of radiation therapy for cancer has long been associated with the intrinsic radio-resistance or radio-sensitivity of tumor cells, a new approach is demonstrating that radiation can take credit for an additional benefit -; causing highly effective secondary immune responses that can enhance anti-tumor immunity.

28 Aug 2018

Insilico announces presentation of latest research at Global Precision Medicine & Biomarkers Leaders Summit

Insilico Medicine, a Rockville-based company specializing in the application of next-generation artificial intelligence for drug discovery, biomarker development and aging research, announces the presentation of its CTO, Alex Zhebrak at the 5th Global Precision Medicine & Biomarkers Leaders Summit, September 13-14, 2018, Munich, Germany.

27 Aug 2018

Evotec collaborates with CENTOGENE to develop compounds to treat rare genetic diseases

CENTOGENE today announced that Evotec AG and CENTOGENE AG entered into a global strategic collaboration agreement for joint drug discovery projects, developing compounds to treat rare genetic diseases.

27 Aug 2018

INRS professors develop innovative strategy to identify leishmanicidal molecules

Leishmania is a microorganism that enters the human body via a sandfly bite. Instead of fleeing the white blood cells deployed by the immune system to destroy it, the parasite allows itself to be swallowed up.

24 Aug 2018

Ubiquigent launches REDOXprofiler for rapid identification of REDOX cycling compounds

Ubiquigent Limited, a company specializing in providing ubiquitin cell-signalling system drug discovery services, research tools and novel targeted chemistry, announced today that it has launched REDOXprofiler.

24 Aug 2018

MDA announces 34 new grants totaling $9.9 million to accelerate neuromuscular research

The Muscular Dystrophy Association today announced the award of 34 new grants totaling more than $9.9 million for its summer round of funding. These new grants represent a continued commitment by MDA to fund groundbreaking research that will accelerate treatments and cures for the more than 40 diseases in its program.

24 Aug 2018

UAB awarded nearly $18.9 million to study effects and potential antidotes of arsenical exposure

The University of Alabama at Birmingham has been awarded nearly $18.9 million by the National Institutes of Health Countermeasures Against Chemical Threats Program and National Institute of Environmental Health Sciences to support the UAB Research Center of Excellence in Arsenicals.

23 Aug 2018

Drug Discovery News and Research

Further Reading

New project aims to increase patient willingness to take life-saving oral drugs

New research on molecular mechanistic understanding of drug delivery and drug delivery systems

Researchers design new medicine to treat highly aggressive pancreatic cancer

Discovery of unusual biosynthetic pathways could aid in the search for new natural products

Improve reliability, accuracy of drug discovery process with new 3D cell analysis technology

Barrow Institute initiates $50 million effort to seek cure for glioblastoma

BioIVT announces research into mechanisms involved in cholestatic drug-induced liver injury

NCCN updates Clinical Practice Guidelines to include new recommendations for CABOMETYX tablets

Meet Axol Bioscience at 2018 Cambridge International Stem Cell Symposium

Biophysicists propose new way to identify crucial factors for protein folding

Vertex, Genomics team up to improve discovery of precision medicines

Hesperos receives SBIR grant to create ‘human-on-a-chip’ model to mimic Alzheimer's disease

Researchers uncover why some cancers grow faster than others

A non-canonical approach may improve radiation treatment for cancer

Insilico announces presentation of latest research at Global Precision Medicine & Biomarkers Leaders Summit

Evotec collaborates with CENTOGENE to develop compounds to treat rare genetic diseases

INRS professors develop innovative strategy to identify leishmanicidal molecules

Ubiquigent launches REDOXprofiler for rapid identification of REDOX cycling compounds

MDA announces 34 new grants totaling $9.9 million to accelerate neuromuscular research

UAB awarded nearly $18.9 million to study effects and potential antidotes of arsenical exposure

eBook: Essential guide to organoids in drug discovery eBook

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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