Drug Discovery News and Research

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The drug discovery process begins with recognizing a disease or clinical condition in which there is a lack of adequate medical treatment. Once a potential drug has been identified, pre-clinical research can begin. This process includes several stages; the first of which involves identifying and validating the prospective drug’s target through assay development, high throughput screening, hit identification and finally, lead optimization. Once the pre-clinical process is complete, the newly synthesized drug candidate is selected for future clinical development.

UK-based charity to accelerate development of promising new drug for Parkinson's

UK-based charity, Parkinson's UK is set to provide more than $1million in funding to US biotech company, Neurolixis, to accelerate the development of a promising new drug for people with Parkinson's.

24 Jan 2018

BioAxial receives US patent for new ‘black fluorophore’ technology

BioAxial, a key player in live cell super resolution microscopy, today announces that it has been granted a US patent covering ‘black fluorophore’, a pivotal component of ‘dark tracking’ technology. This patent consolidates BioAxial’s patent portfolio, which already comprises ten patent families. It also strengthens the company’s position as a technology leader in the field of commercial super-resolution imaging modules.

24 Jan 2018

Combination chemotherapy increases survival in animal models of glioblastoma

A diagnosis of the brain cancer glioblastoma carries a dismal prognosis, with most patients dying within five years.

23 Jan 2018

Toothpaste ingredient could be employed as anti-malarial drug against drug-resistant parasites

An ingredient commonly found in toothpaste could be employed as an anti-malarial drug against strains of malaria parasite that have grown resistant to one of the currently-used drugs.

19 Jan 2018

A new strategy proposed for drug discovery

A joint industry/academia study of a cancer target protein reveals unusual relation between binding site flexibility and drug-target lifetime.

17 Jan 2018

Insilico Medicine develops new deep-learning based hematological human aging clock

Today, Insilico Medicine, Inc., a Baltimore-based company specializing in the application of artificial intelligence for drug discovery, biomarker development and aging research, announced a publication of a research paper titled "Population-specific biomarkers of human aging: a big data study using South Korean, Canadian and Eastern-European patient populations" in The Journal of Gerontology.

11 Jan 2018

Pfizer to stop Alzheimer’s and Parkinson’s disease research

Pharmaceutical giant Pfizer has announced its intention to stop research and development in areas including Alzheimer’s disease and Parkinson’s disease.

11 Jan 2018

Alzheimer’s Research UK calls on pharma to continue supporting dementia research

Alzheimer’s Research UK is calling for a recommitment from pharmaceutical companies to continue efforts to fund research into dementia, the leading cause of death in the UK.

10 Jan 2018

Researchers awarded grant to repurpose FDA-approved drugs for treating Alzheimer's patients

Researchers from Case Western Reserve University School of Medicine and collaborators have received a five-year, $2.8 million grant from the National Institute on Aging to identify FDA-approved medications that could be repurposed to treat Alzheimer's disease.

9 Jan 2018

Researchers uncover powerful new model for studying hallmark of vascular disease

While refining ways to grow arterial endothelial cells in the lab, a regenerative biology team at the Morgridge Institute for Research at the University of Wisconsin-Madison unexpectedly unearthed a powerful new model for studying a hallmark of vascular disease.

9 Jan 2018

Vanderbilt and Lundbeck collaborate to develop novel approach for treating schizophrenia

Vanderbilt University has signed separate licensing and research collaboration agreements with Lundbeck, a global pharmaceutical company based in Denmark, to develop a novel approach for treating schizophrenia.

9 Jan 2018

Regeneron forms consortium to accelerate largest widely-available human sequencing resource

By the end of 2019, Regeneron plans to sequence the exomes of all 500,000 people within the UK Biobank resource, all with associated health records, creating an unprecedented resource linking human genetic variations to human biology and disease.

9 Jan 2018

Supercharged old drugs could destroy world's most dangerous superbugs

An old drug supercharged by University of Queensland researchers has emerged as a new antibiotic that could destroy some of the world's most dangerous superbugs.

5 Jan 2018

Newly solved glucagon receptor structure provides most accurate template for drug design

Class B G protein-coupled receptors (GPCRs) exert essential action in hormonal homeostasis and are important therapeutic targets for a variety of diseases including metabolic disorders such as type 2 diabetes.

4 Jan 2018

Researchers discover novel genes responsible for Alzheimer's disease

Researchers have identified several new genes responsible for Alzheimer's disease (AD) including those leading to functional and structural changes in the brain and elevated levels of AD proteins in cerebrospinal fluid (CSF).

3 Jan 2018

UGR study paves way for development of better analgesics to treat joint pain

Researchers from the University of Granada have led a novel study in mice which shows that neurons mediating joint pain are different from those mediating cutaneous pain.

19 Dec 2017

Researchers explore how toxic protein clusters linked to Parkinson's disrupt brain cells

Researchers have glimpsed how the toxic protein clusters that are associated with Parkinson's Disease disrupt the membranes of healthy brain cells, creating defects in the cell walls and eventually causing a series of events that induce neuronal death.

15 Dec 2017

New high precision machine-learning model could help accelerate drug discovery

Drug discovery could be significantly accelerated thanks to a new high precision machine-learning model, developed by an international collaboration of researchers, including the University of Warwick.

14 Dec 2017

Research findings offer path for drug discovery to treat hyperaldosteronism

A new study led by researchers at Sanford Burnham Prebys Medical Discovery Institute, in collaboration with researchers at Eunice Kennedy Shriver National Institute of Child Health and Human Development, part of the National Institutes of Health, identifies a mechanism that explains the development of hyperaldosteronism.

7 Dec 2017

Overcoming Challenges of Assays of Complex Cellular Models with Real-Time Live-Cell Analysis

There's a continued drive towards making in vitro assays ever more translational towards in vivo models and ultimately the clinic. This ties in with the resurgence of phenotypic screening and is a response to the perceived poor translation of the traditional simple cell-based assays, often developed to study just single protein targets.

From Sartorius 5 Dec 2017

Drug Discovery News and Research

Further Reading

UK-based charity to accelerate development of promising new drug for Parkinson's

BioAxial receives US patent for new ‘black fluorophore’ technology

Combination chemotherapy increases survival in animal models of glioblastoma

Toothpaste ingredient could be employed as anti-malarial drug against drug-resistant parasites

A new strategy proposed for drug discovery

Insilico Medicine develops new deep-learning based hematological human aging clock

Pfizer to stop Alzheimer’s and Parkinson’s disease research

Alzheimer’s Research UK calls on pharma to continue supporting dementia research

Researchers awarded grant to repurpose FDA-approved drugs for treating Alzheimer's patients

Researchers uncover powerful new model for studying hallmark of vascular disease

Vanderbilt and Lundbeck collaborate to develop novel approach for treating schizophrenia

Regeneron forms consortium to accelerate largest widely-available human sequencing resource

Supercharged old drugs could destroy world's most dangerous superbugs

Newly solved glucagon receptor structure provides most accurate template for drug design

Researchers discover novel genes responsible for Alzheimer's disease

UGR study paves way for development of better analgesics to treat joint pain

Researchers explore how toxic protein clusters linked to Parkinson's disrupt brain cells

New high precision machine-learning model could help accelerate drug discovery

Research findings offer path for drug discovery to treat hyperaldosteronism

Overcoming Challenges of Assays of Complex Cellular Models with Real-Time Live-Cell Analysis

eBook: Essential guide to organoids in drug discovery eBook

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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