Drug Discovery News and Research

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The drug discovery process begins with recognizing a disease or clinical condition in which there is a lack of adequate medical treatment. Once a potential drug has been identified, pre-clinical research can begin. This process includes several stages; the first of which involves identifying and validating the prospective drug’s target through assay development, high throughput screening, hit identification and finally, lead optimization. Once the pre-clinical process is complete, the newly synthesized drug candidate is selected for future clinical development.

Astex celebrates as breast cancer drug gets European marketing approval

Astex Pharmaceuticals, a pharmaceutical company dedicated to the discovery and development of novel small molecule therapeutics for oncology and diseases of the central nervous system, announced today that its long-standing pharmaceutical collaborator, Novartis, has received marketing approval in Europe for Kisqali (ribociclib) plus an aromatase inhibitor as a first-line treatment in post-menopausal women with hormone receptor positive, human epidermal growth factor receptor-2 negative (HR+/HER2-) locally advanced or metastatic breast cancer.

26 Aug 2017

BioAscent to manage Medivir’s expanding compound library

BioAscent Discovery Limited has taken delivery of Medivir AB’s compound collection of around 56,000 samples, to manage on an outsourced basis.

24 Aug 2017

Researchers use small molecule to relieve symptoms of Rett syndrome in mouse model

Vanderbilt University researchers have relieved symptoms of Rett syndrome in a mouse model with a small molecule that works like the dimmer switch in an electrical circuit.

23 Aug 2017

Id genes found to play crucial role in heart development

Researchers from Sanford Burnham Prebys Medical Discovery Institute (SBP), the Cardiovascular Institute at Stanford University and other institutions were surprised to discover that the four genes in the Id family play a crucial role in heart development, telling undifferentiated stem cells to form heart tubes and eventually muscle.

22 Aug 2017

UC Irvine pharmacology researchers unearth potential roots of schizophrenia

An abundance of an amino acid called methionine, which is common in meat, cheese and beans, may provide new clues to the fetal brain development that can manifest in schizophrenia, University of California, Irvine pharmacology researchers report in the journal Molecular Psychiatry.

16 Aug 2017

Insilico and GSK collaborate to enhance drug discovery process

Insilico Medicine, a Baltimore-based company at the forefront of artificial intelligence (AI) research for drug discovery, biomarker development and aging research announced today that it has formed a collaboration with GSK to explore how Insilico's AI capability can enhance its drug discovery process.

16 Aug 2017

Livecyte® Kinetic Cytometer system by Phasefocus wins 2017 Microscopy Today Innovation Award

Phasefocus is the proud recipient of a 2017 Microscopy Today Innovation Award for its Livecyte® Kinetic Cytometer system.

From Phase Focus Limited 11 Aug 2017

Scientists create stem cell-based model of rare inherited neurological condition

An international team of scientists, led by University of California San Diego School of Medicine researchers, has created a human stem cell-based model of a rare, but devastating, inherited neurological autoimmune condition called Aicardi-Goutieres Syndrome (AGS).

11 Aug 2017

Cryo-electron microscopy advances by Thermo Fisher Scientific drives structural biology research

Thermo Fisher Scientific, the world leader in serving science, has extended its leadership in cryo-electron microscopy (cryo-EM) with the introduction of two new instruments: the Thermo Scientific Krios G3i and the Thermo Scientific Glacios cryo-transmission electron microscopes (cryo-TEMs).

From Thermo Fisher Scientific Inc. 9 Aug 2017

Bioactive 'tissue papers' show potential for regenerative medicine

Northwestern Medicine scientists and engineers have invented a range of bioactive "tissue papers" made of materials derived from organs that are thin and flexible enough to even fold into an origami bird.

7 Aug 2017

New way of screening compounds may help speed up drug development

Scientists have created a new way of screening compounds that is more sensitive than existing methods, opening up the possibility of finding new drugs for many diseases.

7 Aug 2017

Hitgen and LEO Pharma collaborate to discover small molecule leads for multiple therapeutic targets

HitGen Ltd announced that the company has entered into a multi-target multi-year collaboration with LEO Pharma A/S, to discover novel small molecule leads for multiple therapeutic targets of interest to LEO Pharma.

7 Aug 2017

Scientists reveal new method to reprogram specific T cells

When the immune system is imbalanced, either due to overly-active cells or cells that suppress its function, it causes a wide range of diseases, from psoriasis to cancer.

2 Aug 2017

Takeda and Cardurion announce creation of new cardiovascular development partnership

Takeda Pharmaceutical Company Limited and Cardurion Pharmaceuticals today announced the creation of a new cardiovascular development partnership.

2 Aug 2017

New partnership uses artificial intelligence methods to develop solutions for preventing early aging

Center for Healthy Aging at the University of Copenhagen today announced a research collaboration with a company specializing in artificial intelligence (AI) to develop solutions for preventing early aging.

1 Aug 2017

Juvenescence AI to develop first compounds generated by Insilico's deep-learned drug discovery engines

Insilico Medicine, a Baltimore-based leader in artificial intelligence for drug discovery and biomarker development, is pleased to announce a multi-year drug development agreement with the biotechnology company Juvenescence AI Limited.

28 Jul 2017

New method may help distinguish frontotemporal dementia from Alzheimer's disease

A new method may help determine whether a person has Alzheimer's disease or frontotemporal dementia, two different types of dementia that often have similar symptoms, according to a preliminary study published in the July 26, 2017, online issue of Neurology, the medical journal of the American Academy of Neurology.

27 Jul 2017

Nanomedical Diagnostics introduces new NTA biosensor for faster, reliable characterization of proteins

Nanomedical Diagnostics, a cutting-edge life science company pioneering graphene biosensors that accelerate pharmaceutical and biotherapeutics development, announces the launch of a new NTA biosensor chip for use with its label-free Agile R100 assay system.

26 Jul 2017

Likarda uses INTEGRA’s VIAFLO ASSIST to automate cell-based assay development

INTEGRA has published a new video that demonstrates how US-based biotech contract research specialists Likarda LLC are using their VIAFLO ASSIST to cost effectively develop high throughput cell based assays for their customers.

From INTEGRA Biosciences 24 Jul 2017

Researchers devise strategy to target Achilles heel of nervous system cancers

Virtually all cancer treatments used today also damage normal cells, causing the toxic side effects associated with cancer treatment.

21 Jul 2017

Drug Discovery News and Research

Further Reading

Astex celebrates as breast cancer drug gets European marketing approval

BioAscent to manage Medivir’s expanding compound library

Researchers use small molecule to relieve symptoms of Rett syndrome in mouse model

Id genes found to play crucial role in heart development

UC Irvine pharmacology researchers unearth potential roots of schizophrenia

Insilico and GSK collaborate to enhance drug discovery process

Livecyte® Kinetic Cytometer system by Phasefocus wins 2017 Microscopy Today Innovation Award

Scientists create stem cell-based model of rare inherited neurological condition

Cryo-electron microscopy advances by Thermo Fisher Scientific drives structural biology research

Bioactive 'tissue papers' show potential for regenerative medicine

New way of screening compounds may help speed up drug development

Hitgen and LEO Pharma collaborate to discover small molecule leads for multiple therapeutic targets

Scientists reveal new method to reprogram specific T cells

Takeda and Cardurion announce creation of new cardiovascular development partnership

New partnership uses artificial intelligence methods to develop solutions for preventing early aging

Juvenescence AI to develop first compounds generated by Insilico's deep-learned drug discovery engines

New method may help distinguish frontotemporal dementia from Alzheimer's disease

Nanomedical Diagnostics introduces new NTA biosensor for faster, reliable characterization of proteins

Likarda uses INTEGRA’s VIAFLO ASSIST to automate cell-based assay development

Researchers devise strategy to target Achilles heel of nervous system cancers

eBook: Using iPSCs models for human disease research and drug discovery eBook

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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