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Breakthrough in gene editing: Enhanced virus-like particles promise new era in genetic disease treatment

Researchers developed an advanced prime editor-engineered virus-like particle (PE-eVLP) system, significantly enhancing gene editing efficiency in human cells and showing potential for treating genetic diseases.

9 Jan 2024

First-of-its-kind research shines light on how certain pathogens can outwit the body's immune system

In a first-of-its-kind research breakthrough, a team of scientists at the University of Massachusetts Amherst has analyzed and described what they call the "mosquito effect," which sheds light on how certain pathogens, such as cancerous tumor cells, can outwit the body's immune system.

8 Jan 2024

New compound effective against bacterial species resistant to multiple classes of existing antibiotics

Recent studies by Zampaloni et al. and Pahil et al. published in the journal Nature describe a novel method of inhibiting the growth of Gram-negative bacteria such as Acinetobacter using antibiotics consisting of macrocyclic peptides that target the bacterial protein bridge machinery that transports lipopolysaccharides from the cytoplasm to the outer membrane.

4 Jan 2024

Simple technique boosts antibody delivery for treating brain diseases

The blood-brain barrier blocks the entry of antibodies into the brain. This limits the potential use of antibody therapeutics to treat brain diseases, such as brain tumors.

3 Jan 2024

Understanding the genetic basis of hereditary diffuse gastric cancer

Gastric cancer, a significant global health burden, claims over 7% of cancer-related deaths annually. Although only 1-3% of cases have a genetic basis, understanding these genetic drivers is crucial for developing preventative strategies.

26 Dec 2023

Shedding new light on the hidden organization of the cytoplasm

Back in 2018, the lab of Christine Mayr, MD, PhD, at Memorial Sloan Kettering Cancer Center (MSK) introduced the world to a key cellular component that had been hiding in plain sight.

21 Dec 2023

Research shows how the immune system keeps Herpes simplex virus at bay

Herpes simplex virus (HSV) is extremely common, affecting nearly two-thirds of the world's population, according to the World Health Organization.

14 Dec 2023

$153,000 grant fuels research on new approaches to inhibit STAT3 and develop novel cancer treatments

With an estimated 1.9 million new cases and more than 600,000 deaths each year, cancer remains the second most common cause of death in the U.S., trailing only heart disease. And while there are more than 200 types of cancer, the abnormal synthesis of a protein known as STAT3 is unique to the majority of tumors.

13 Dec 2023

Non-invasive cancer monitoring takes a leap forward with new microfluidic technology

Monitoring cancer cells effectively can help physicians with treatment and management, thus reducing cancer-related mortality.

11 Dec 2023

Salk scientists uncover mechanism for repairing damaged nerves during peripheral neuropathy

Each year in the United States there are more than 3 million cases of peripheral neuropathy, wherein nerves outside of the brain and spinal cord are damaged and cause pain and loss of feeling in the affected areas.

28 Nov 2023

Bacteria fight phages with RNA-based immune defense

There's no organism on earth that lives free of threat-;including bacteria. Predatory viruses known as phages are among their most dire foes, infiltrating their cells to replicate and take over.

15 Nov 2023

Preclinical research points to a promising new treatment option for pancreatic cancer patients

Preclinical research published in the Journal for ImmunoTherapy of Cancer points to a promising new treatment option for people with pancreatic cancer.

10 Nov 2023

Researchers discover new mechanism of cancer treatment resistance

A surprising mechanism that makes some cancers treatment-resistant has been discovered by Weill Cornell Medicine and NewYork-Presbyterian investigators.

2 Nov 2023

Axon Biology & The Future of Drug Discovery: A Deep Dive with Dr Federico Dajas-Bailador

News-Medical sits down with Dr. Federico Dajas-Bailador, a leading expert in axon biology and drug discovery.

From ELRIG (UK) Ltd. 31 Oct 2023

Study unveils new approach to more precise, long-lasting, and less toxic cancer treatment

For too long, cancer treatment has been a double-edged sword – the very treatments designed to kill cancer cells often wrought havoc on healthy ones too.

30 Oct 2023

NF-κB activation during COVID-19 and its impact on patients with hypertension

Researchers review the role of NF-κB activation in the replication of SARS-CoV-2 and the impact of COVID-19 medications on NF-κB activation.

25 Oct 2023

Researchers study how cells adapt to stressful and complex environments

Imagine the life of a yeast cell, floating around the kitchen in a spore that eventually lands on a bowl of grapes. Life is good: food for days, at least until someone notices the rotting fruit and throws them out.

16 Oct 2023

Study shows how chronic sleep loss can damage the heart

Does this sound like you? You wake up at the same time each morning, get the kids out the door, and rush to catch the subway to work. But at night, maybe you stay up until midnight doing laundry or 1 a.m. to catch up on the bills.

13 Oct 2023

New insights into coronavirus E channel could lead to antiviral drugs

The genome of the SARS-CoV-2 virus encodes 29 proteins, one of which is an ion channel called E. This channel, which transports protons and calcium ions, induces infected cells to launch an inflammatory response that damages tissues and contributes to the symptoms of Covid-19.