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International research sheds light on Escherichia coli

An unprecedented picture of how bacteria latch on to human cells has been published by UK, French and US scientists. They have produced a finely detailed model of one of the tools used by some of the nastiest varieties of the stomach bug, Escherichia coli, to stick to and gain entry to host cells.

1 Sep 2004

High-resolution images reveal the molecular rearrangements that rotavirus uses to break into cells

High-resolution images constructed by researchers at Children's Hospital Boston and Harvard Medical School reveal the molecular rearrangements that rotavirus – the most common cause of severe, dehydrating diarrhea and vomiting in children worldwide – uses to break into cells.

25 Aug 2004

Computed tomography may improve screening of latent atherosclerosis

Atherosclerosis is the progressive narrowing and hardening of the arteries over time, known to occur to some degree with aging; but other risk factors (such as high cholesterol, high blood pressure, smoking, diabetes and family history for atherosclerotic disease) that accelerate this process have been identified.

18 Aug 2004

Drug developers should take a different approach to snake venom and heart medications

With the help of snake venom and sophisticated laboratory testing, scientists believe they've uncovered the reason why a group of new heart medications were doing some patients more harm than good.

17 Aug 2004

New imaging technique may help cystic fibrosis sufferers

Now, Jefferson Lab scientists have used their expertise to build a small animal medical imager that's helping researchers develop a new gene therapy technique for cystic fibrosis.

15 Aug 2004

Trick illustrates life’s determination to survive hostile environments

Dipping your hands into 160-degree water is guaranteed to give you an immediate and severe scalding - unless you’re one of the few species of bacteria that manage to thrive in temperatures that would maim or kill the rest of the Earth’s inhabitants.

13 Aug 2004

Researchers map structure of anti-cancer molecule and open the door to the creation of more effective cancer treatments

Scientists at Emory University, in collaboration with researchers at three national laboratories, have solved the structural puzzle of how an emerging class of promising cancer drugs works to halt cell division. The discovery potentially opens the door to the creation of more effective cancer treatments.

13 Aug 2004

Promising families of drugs combat the spread of tumors in different ways

Pharmaceutical companies seeking to design more effective cancer chemotherapy agents may have an easier road ahead than was previously believed.

9 Aug 2004

A prototype microscope that uses neutrons instead of light to "see" magnified images

A prototype microscope that uses neutrons instead of light to "see" magnified images has been demonstrated at the National Institute of Standards and Technology. Neutron microscopes might eventually offer certain advantages over optical, X-ray and electron imaging techniques such as better contrast for biological samples.

2 Aug 2004

Gene responsible for infertility

A paper describing discoveries about the role of a gene that is important in all animals, plants, and fungi is published in the 20 July 2004 issue of the journal Proceedings of the National Academy of Sciences.

23 Jul 2004

Rabies infections in organ donor and transplant recipients

On June 30, 2004, CDC confirmed diagnoses of rabies in three recipients of transplanted organs and in their common donor, who was found subsequently to have serologic evidence of rabies infection.

2 Jul 2004

Three-dimensional cryo-electron microscope may help guide the design of new antibiotics

Understanding the last step of protein synthesis – the basic process of translating DNA into its final protein product – just became more clear both literally and figuratively.

1 Jul 2004

Patent for orally administrable pharmaceutical may aid treatment of overdose patients

Global nanotechnology company pSivida Limited, is pleased to announce that its UK operating subsidiary pSiMedica Limited has been granted a new Australian patent for BioSiliconTM.

30 Jun 2004

Oldest evidence yet of a human hereditary genetic disorder found

The discovery of what is believed to be the oldest evidence yet found of a human hereditary genetic disorder has been announced by researchers at the Hebrew University of Jerusalem.

28 Jun 2004

Paclitaxel analog kills more cancer cells than natural product

Paclitaxel, a natural compound from yew trees, is the world's best-selling anticancer drug. Several analogs are in clinical trial, with others in preclinical development. One problem that paclitaxel and all its analogs share, however, is that they are all highly complex compounds, and cannot be prepared synthetically in a commercially viable way.

21 Jun 2004

Discovery may help to define the limits for life on Earth, as well as elsewhere in the universe

The discovery of millions of micro-microbes surviving in a 120,000-year-old ice sample taken from 3,000 meters below the surface of the Greenland glacier was announced by Penn State scientists today (May 26) at the General Meeting of the American Society for Microbiology in New Orleans, La. The discovery may help to define the limits for life on Earth, as well as elsewhere in the universe, such as on cold planets like Mars.

27 May 2004

Link between oral bacterium and premature babies

For years, scientists have noticed a particular oral bacterium can be found in the amniotic fluid of about 20 percent of women with premature babies.

27 May 2004

Cultured nanoparticles from filtered homogenates of diseased calcified human cardiovascular tissue

Researchers at the Mayo Clinic found they could isolate and culture nanoparticles from filtered homogenates of diseased calcified human cardiovascular tissue. These cultured nano-sized particles were recognized by a DNA-specific dye, incorporated radiolabeled uridine, and after decalcification, appeared via electron microscopy to contain cell walls.

24 May 2004

Multimillion-dollar electron microscope unveils shapes of viruses and proteins

With a multimillion-dollar electron microscope and computer programs that can pick out the shapes of structures only six atoms wide, Dr. Wah Chiu and his colleagues at Baylor College of Medicine in Houston are attempting to explain the intricate structures of viruses and proteins.

19 May 2004

Glucose metabolism could be used to selectively destroy cancer cells

Scientists have known for decades that cancer cells consume more glucose than normal cells. A longstanding assumption that the excess glucose metabolism was needed to make energy has not been borne out by research studies.

15 May 2004