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Insilico Medicine leverages AI to identify promising new target for breast and gynecological cancers

Insilico Medicine("Insilico"), a clinical stage generative artificial intelligence (AI)-driven drug discovery company, recently published an early research that it has identified MYT1 as a promising new therapeutic target for breast and gynecological cancer, and discovered a series of novel, potent, and highly selective inhibitors specifically targeting MYT1.

19 Jan 2024

Evaluating the effectiveness and safety of single-port robot-assisted technique in nipple-sparing mastectomy procedures

Researchers evaluated the safety and feasibility of a single-port (SP) robotic-assisted approach for performing nipple-sparing mastectomies (NSM).

19 Jan 2024

Study shows Omicron variants evade immune system like predecessors, suggesting key evolutionary trait in SARS-CoV-2

Researchers compared SARS-CoV-2 Omicron variant of concern replication in human cell lines and primary airway cultures and measured host responses to infection.

19 Jan 2024

Mathematical modeling demonstrates efficacy of combinational drug therapy for breast cancer treatment

Researchers use a mathematical model to assess the efficacy of a new combinational therapy of AZD9496 and palbociclib for breast cancer treatment.

18 Jan 2024

ALS progression linked to mitochondria-associated membrane-ER disconnection

Researchers at Nagoya University in Japan have discovered a relationship between the progression of amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, and the disruption of mitochondria-associated membranes (MAM), the contact point between the mitochondria and the endoplasmic reticulum (ER) of the cell.

17 Jan 2024

Unlocking the anti-inflammatory secrets of bergamot byproducts

The positive effect of bergamot derivatives.

17 Jan 2024

TRPC3 emerges as key player in preventing damage from alcohol-associated liver disease

Excessive alcohol intake is strongly associated with alcohol-associated liver disease (ALD) which accounts for 25% and 30% of deaths from cirrhosis and hepatocellular carcinoma. Impairment of Ca2+ influx and Ca2+-mediated signaling in ALD suggests that Ca2+ channels are important in ALD pathological progression.

16 Jan 2024

GRK2: A new target for inhibiting macrophage infiltration and angiogenesis in rheumatoid arthritis

This new article publication from Acta Pharmaceutica Sinica B, discusses how GRK2 inhibits Flt-1+ macrophage infiltration and its proangiogenic properties in rheumatoid arthritis.

15 Jan 2024

Revolutionary AI tool forecasts kidney injury signs with high accuracy in intensive care

A machine-learning (ML) algorithm for predicting oliguria.

15 Jan 2024

Pazopanib activity confirmed in EWSR1-NFATC2 bone sarcoma

A new case report was published in Oncoscience (Volume 10) on September 20, 2023, entitled, "Activity of pazopanib in EWSR1-NFATC2 translocation-associated bone sarcoma."

12 Jan 2024

Breakthrough in diabetes management: Cold water exercise and cinnamon shows promising results

The effects of swimming and cinnamon supplementation on TBC1D1, HbA1C levels, and TBC1D4.

12 Jan 2024

Key protein EPAC1 found to regulate brown fat growth, offering obesity treatment potential

Study reveals that EPAC1 protein plays a crucial role in regulating the growth of brown and beige adipose tissue, offering potential avenues for treating obesity and improving cardiometabolic health.

11 Jan 2024

Glioblastoma tumor cells mimic neurons to evade treatment

Certain cancers are more difficult to treat because they contain cells that are highly skilled at evading drugs or our immune systems by disguising themselves as healthy cells.

11 Jan 2024

Non-smokers' lung cancer among top five global cancer-related deaths in 2023

The development of lung cancer in individuals who have never smoked.

11 Jan 2024

Sesame oil supplementation: a potential breakthrough in postmenopausal osteoporosis prevention?

Daily sesame oil supplementation in ovariectomized rats was found to prevent osteoporosis by enhancing bone formation, reducing bone resorption, and maintaining serum estrogen and aromatase levels.

7 Jan 2024

Unlocking the power of diet: How miRNAs influence health and disease

The role of dietary microRNAs (miRNAs) in health and disease.

5 Jan 2024

GFH009 disrupts growth signals and triggers apoptosis in hematologic malignancies

A new research paper was published in Oncotarget's Volume 14 on December 20, 2023, entitled, "The pharmacodynamic and mechanistic foundation for the antineoplastic effects of GFH009, a potent and highly selective CDK9 inhibitor for the treatment of hematologic malignancies."

28 Dec 2023

Kinase News and Research

Insilico Medicine leverages AI to identify promising new target for breast and gynecological cancers

Evaluating the effectiveness and safety of single-port robot-assisted technique in nipple-sparing mastectomy procedures

Study shows Omicron variants evade immune system like predecessors, suggesting key evolutionary trait in SARS-CoV-2

Mathematical modeling demonstrates efficacy of combinational drug therapy for breast cancer treatment

ALS progression linked to mitochondria-associated membrane-ER disconnection

Unlocking the anti-inflammatory secrets of bergamot byproducts

TRPC3 emerges as key player in preventing damage from alcohol-associated liver disease

GRK2: A new target for inhibiting macrophage infiltration and angiogenesis in rheumatoid arthritis

Revolutionary AI tool forecasts kidney injury signs with high accuracy in intensive care

Pazopanib activity confirmed in EWSR1-NFATC2 bone sarcoma

Breakthrough in diabetes management: Cold water exercise and cinnamon shows promising results

Key protein EPAC1 found to regulate brown fat growth, offering obesity treatment potential

Glioblastoma tumor cells mimic neurons to evade treatment

Non-smokers' lung cancer among top five global cancer-related deaths in 2023

Sesame oil supplementation: a potential breakthrough in postmenopausal osteoporosis prevention?

Unlocking the power of diet: How miRNAs influence health and disease

GFH009 disrupts growth signals and triggers apoptosis in hematologic malignancies

Common inflammation pathway turns anthrax toxin into killer

Study sheds light on enzyme's role in advanced prostate cancer progression

St. Jude researchers reveal structure of Parkinson's-linked proteins

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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