ARGEN is a patented light scattering instrument that addresses key research and development issues in the biopharmaceutical industry by providing real-time stability monitoring, manufacturing stress modeling, shelf-life determination, and rapid parallel analyses. ARGEN, which comes equipped with intuitive data processing packages, was created for the quick or long-term assessment of the viability and stability of proteins, peptides, DNA/RNA, and other biopolymers.
ARGEN has multiple independent sample cells and can identify the early onset of aggregation and degradation when biopolymer samples are exposed to mechanical, thermal and chemical stress. Users can even exchange samples without disrupting other ongoing experiments and determine solution behavior and biopolymer stability at low temperatures (3°C-8°C), which is useful in predicting the shelf-life of a biopharmaceutical during shipping and storage conditions.
These benefits have helped biopharmaceutical companies worldwide create more effective biologic products more efficiently. Learn more about ARGEN today and begin optimizing your drug and formulation development processes to lower costs, improve workflow efficiency, and accelerate time to market.
ARGEN™ Target Biopolymers. Image Credit: Yokogawa Life Science
ARGEN™ applications
- Kinetic analysis of peptide aggregation
- Formulating four peptides
- Comparing protein stability
- Development of formulation
- Determining Mw and B22 of mAbs
ARGEN™ key features
- Expedited development: The time and resources needed to discover ideal target formulations can be reduced by up to 16 times.
- Flexible operation: Continuous and adaptable operation for temporal stability investigations and determining shelf life.
- Matrix DOE: Matrix DOE enables quick screening of thermal, chemical, and mechanical stress effects.
- Intuitive software: Proprietary control and analysis software with an easy-to-use interface for all areas of experimental design and independent control of cells.
ARGEN™ key benefits
- Understand the influence of thermal, chemical, and mechanical stresses
- Rank the stability of proteins, peptides, and other biopolymers
- Smarter product development
- Early detection of aggregation and degradation
ARGEN™ key outputs
- Mw(t)/M0: Molecular weight normalized in relation to native molecular weight
- Mw(abs): Absolute molecular weight
- AR: Aggregation Rate
- Time to dimerization: Transitioning from monomer to dimer
- Arrhenius plots: Characterize the aggregation and degradation kinetics