Drug Discovery & Pharmaceuticals

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New substance boosts the effect of protein-based COVID-19 vaccines

Ironically, some vaccines need their own "boosters." Adding an ingredient called an adjuvant can help vaccines elicit a more robust immune response, better training the body to fight a pathogen.

1 Sep 2022

Researchers receive $1.2 million Keck Foundation grant to find molecules for targeting the 'undruggable proteome'

The W.M. Keck Foundation has awarded a $1.2 million grant to medicinal chemistry and computational biology researchers at the University of Kansas and the University of Chicago focused on addressing a long-unresolved problem in biomedical research -; finding molecules able to target the "undruggable proteome."

29 Aug 2022

Using AI to foster productivity in pharmaceutical research and development

As part of our SLAS Europe 2022 coverage, we speak to Sree Vadlamudi from Iktos, about how we can adopt AI to help foster productivity within pharmaceutical research.

From Society for Laboratory Automation and Screening (SLAS) 25 Aug 2022

CRISPR genome-editing technology can be used as a tool to discover RNA therapeutics for lung cancer

An international team of scientists have demonstrated for the first time that CRISPR genome-editing technology can be used as a tool to find new gene therapies for lung cancer.

24 Aug 2022

Glucokinase activator AZD1656 shows potential benefit for diabetics with moderate to severe COVID-19

A new study examines the potential benefit of the glucokinase activator molecule AZD1656 in the ARCADIA trial.

23 Aug 2022

Experts urge FDA to include T cell responses when evaluating COVID vaccines

Now, a group of prominent scientists and physicians are urging the FDA to include in its guidance to vaccine developers a recommendation for T-cell assessment in COVID-19 vaccine clinical trials to more comprehensively measure immune response.

11 Aug 2022

Vaccines and monoclonal antibodies being developed for respiratory syncytial virus

A new study reviews recent advancements made in the development of RSV immunoprophylactic measures.

11 Aug 2022

New compound proves to be potent against more than 300 drug-resistant bacteria

Urinary tract infections are common, yet are increasingly tough to treat because the bacteria that cause them are becoming resistant to many antibiotics.

10 Aug 2022

A broad sarbecovirus-neutralizing antibody cocktail

Researchers present a rational approach for identifying SARS-CoV-2 receptor-binding domain-targeted broad neutralizing antibody cocktails.

9 Aug 2022

Next-generation monoclonal antibody prevents malaria

Researchers investigate the pharmacokinetics and safety of L9LS, a monoclonal antibody to prevent malaria.

9 Aug 2022

Scripps, UCLA chemists develop a 'molecular editing' toolkit for modifying bicyclic aza-arenes

Chemists from Scripps Research and the University of California, Los Angeles, have developed methods for the precise, flexible modification of a broad class of chemical compounds called bicyclic aza-arenes, which are commonly used to build drug molecules.

9 Aug 2022

Sustainable Science; What does the future look like?

We speak to Ali Safavi, CEO and Founder of Grenova about sustainable science, the impact life sciences research is having on our planet, and the solutions they offer for laboratories to help reduce their plastic waste.

From Grenova 8 Aug 2022

New method can modify an entire substance class of medically relevant natural products

The use of the element fluorine to modify active substances is an important tool in modern drug development.

5 Aug 2022

Novel fusion protein drug for Alzheimer’s disease circumvents the neurotoxic inflammatory side effects

Although Aduhelm, a monoclonal antibody targeting amyloid beta (Aβ), recently became the first US FDA approved drug for Alzheimer's disease (AD) based on its ability to decrease Aβ plaque burden in AD patients, its effect on cognitive improvement is still controversial.

4 Aug 2022

A combined influenza and COVID-19 mRNA vaccine

A combined mRNA vaccine is capable of inducing broad and durable protection against co-infection with SARS-CoV-2 and IAV,

3 Aug 2022

Turning to Organ-on-a-Chip Studies for the Future of Drug Discovery

In this interview, we speak to Tom Kostrzewski, VP of Science and Technology at CN Bio, about their organ-on-a-chip product and the future of drug discovery.

From CN-Bio 3 Aug 2022

Shear-thinning biomaterial-based minimally invasive strategy for delivery of targeted immunotherapy

Researchers at the Terasaki Institute for Biomedical Innovation (TIBI) have developed and optimized a minimally invasive method for more targeted, efficient, and sustained delivery of immunotherapeutic treatments for cancer.

2 Aug 2022

LJI acquires Carterra LSA instrument to enhance antibody screening and characterization efforts

Carterra, Inc., the world leader in innovative technologies enabling high-throughput biology, and La Jolla Institute for Immunology, a globally recognized non-profit research organization dedicated to understanding the power of the immune system to promote human health, announced today that LJI has acquired a Carterra LSA instrument to enhance its antibody screening and characterization work.

2 Aug 2022

SLAS; Connecting the Life Sciences to Accelerate Research

As part of our SLAS Europe 2022 coverage, we speak to Vicki Louise, CEO of SLAS, about the importance of collaboration in accelerating life sciences research.

From Society for Laboratory Automation and Screening (SLAS) 1 Aug 2022

Decoy ACE2 receptors broadly neutralize SARS-CoV-2 variants

Researchers review current developments in preclinical studies associated with recombinant ACE2 decoy receptors against coronaviruses.

31 Jul 2022

Drug Discovery & Pharmaceuticals

New substance boosts the effect of protein-based COVID-19 vaccines

Researchers receive $1.2 million Keck Foundation grant to find molecules for targeting the 'undruggable proteome'

Using AI to foster productivity in pharmaceutical research and development

CRISPR genome-editing technology can be used as a tool to discover RNA therapeutics for lung cancer

Glucokinase activator AZD1656 shows potential benefit for diabetics with moderate to severe COVID-19

Experts urge FDA to include T cell responses when evaluating COVID vaccines

Vaccines and monoclonal antibodies being developed for respiratory syncytial virus

New compound proves to be potent against more than 300 drug-resistant bacteria

A broad sarbecovirus-neutralizing antibody cocktail

Next-generation monoclonal antibody prevents malaria

Scripps, UCLA chemists develop a 'molecular editing' toolkit for modifying bicyclic aza-arenes

Sustainable Science; What does the future look like?

New method can modify an entire substance class of medically relevant natural products

Novel fusion protein drug for Alzheimer’s disease circumvents the neurotoxic inflammatory side effects

A combined influenza and COVID-19 mRNA vaccine

Turning to Organ-on-a-Chip Studies for the Future of Drug Discovery

Shear-thinning biomaterial-based minimally invasive strategy for delivery of targeted immunotherapy

LJI acquires Carterra LSA instrument to enhance antibody screening and characterization efforts

SLAS; Connecting the Life Sciences to Accelerate Research

Decoy ACE2 receptors broadly neutralize SARS-CoV-2 variants

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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