Drug Discovery & Pharmaceuticals

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Study offers explanation for why people's responses to the same drug vary widely

Scientists at Scripps Research have comprehensively mapped how a key class of proteins within cells regulates signals coming in from cell surface receptors.

1 Oct 2020

Calibr's novel 'switchable' CAR-T cell therapy granted FDA's Fast Track designation

The U.S. Food and Drug Administration has granted Fast Track designation to a novel "switchable" CAR-T cell therapy developed by Calibr, a division of Scripps Research, in a move to accelerate the drug development and review process.

1 Oct 2020

Compounds repurposed from malaria treatment can kill diarrheal pathogen

A class of compounds used for malaria treatment also kill the intestinal parasite Cryptosporidium, a leading cause of diarrheal disease and death in children that has no cure, a multi-institution collaboration of researchers found in a new study.

1 Oct 2020

Planaria flatworm can be used as reliable alternative for testing topical skin products

Tests for skin treatments could be screened using flatworms rather than other animals such as rabbits, according to new research.

1 Oct 2020

Researchers create drug-like compounds to destroy coronavirus' frameshifting element

Scripps Research chemist Matthew Disney, PhD, and colleagues have created drug-like compounds that, in human cell studies, bind and destroy the pandemic coronavirus' so-called "frameshifting element" to stop the virus from replicating.

30 Sep 2020

Naturally occurring enzyme holds potential as low-cost therapeutic to treat COVID-19

Researchers from UCLA and China have found that catalase, a naturally occurring enzyme, holds potential as a low-cost therapeutic drug to treat COVID-19 symptoms and suppress the replication of coronavirus inside the body.

29 Sep 2020

Researchers develop a new substance that can disarm tumor-promoting proteins

The villain in this drama has a pretty name: Aurora - Latin for dawn. In the world of biochemistry, however, Aurora (more precisely: Aurora-A kinase) stands for a protein that causes extensive damage. There, it has been known for a long time that Aurora often causes cancer.

29 Sep 2020

Valproic acid can interact with DNA conformation and regulate gene expression

Results of recent studies involving valproic acid, used for decades as an anti-convulsant drug, show that it can interact with the conformation of DNA and regulate gene expression.

29 Sep 2020

AXT add Vieworks bio-imaging solutions to their preclinical imaging portfolio

AXT is excited to add the Vieworks range of bio-imaging systems to their preclinical imaging product portfolio. Their in-vivo imaging systems provide outstanding performance in bioluminescent and fluorescent imaging and represents excellent value.

From AXT Pty Ltd 26 Sep 2020

Quantum simulators could help create tomorrow's pharmaceuticals

Trial and error define today's approach to developing new pharmaceutical drugs. But with their enormous computing power, quantum computers are expected to solve important and complex problems in medicine, biology and chemistry, while speeding up the discovery of effective medications.

23 Sep 2020

New T-cell-based vaccine strategy provides broader protection against seasonal influenza

As Americans begin pulling up their sleeves for an annual flu vaccine, researchers at the University of Wisconsin-Madison have provided new insights into an alternative vaccine approach that provides broader protection against seasonal influenza.

23 Sep 2020

Researchers identify a potential drug candidate for hand, foot and mouth disease

A study appearing next week in the journal Nature Communications offers some good news in the search for antiviral drugs for hard-to-treat diseases. Researchers have identified a potential new drug candidate against enterovirus 71, a common cause of hand, foot and mouth disease in infants and young children

22 Sep 2020

Nanoparticle SARS-CoV-2 model could potentially speed the search for drugs

A team of scientists from the National Center for Advancing Translational Sciences and Naval Research Laboratory in Washington, D.C., has developed a new tool that mimics how SARS-CoV-2 -- the virus that causes COVID-19 -- infects a cell, information that could potentially speed the search for treatments against the disease.

22 Sep 2020

Ziath introduces new products to assist compound management labs using Acoustix tubes

Ziath has released a module to enable their Mirage, Cube or Express tube readers to decode Brooks Acoustix tubes.

From Ziath Ltd 18 Sep 2020

RUDN geneticist finds a bifidobacterial protein that can reduce inflammation in COVID-19

A geneticist from RUDN University studied the effect of Bifidobacterium (intestinal bacteria) on the inflammatory process and discovered that their surface protein is capable of stopping excessive or uncontrollable inflammation, like the one observed in COVID-19 patients.

14 Sep 2020

Tiny antibody component shows high potency in SARS-CoV-2 animal models

University of Pittsburgh School of Medicine scientists have isolated the smallest biological molecule to date that completely and specifically neutralizes the SARS-CoV-2 virus, which is the cause of COVID-19.

14 Sep 2020

New bone-on-a-chip device could revolutionize pharmaceutical pre-clinical testing

A new technology that could be used to test new treatments for human organs and bone tissue - all whilst reducing the need for animal research - has been developed by engineers at the University of Sheffield.

14 Sep 2020

Cell signaling research rings warning bells over an emerging cancer drug target

Researchers at the Babraham Institute have used their understanding of cellular signalling to highlight a pitfall in an emerging treatment for cancer and inflammation.

14 Sep 2020

CN Bio partners with Imperial College London to uncover therapeutic targets for alcoholic hepatitis

CN Bio, a leading cell culture company, that has developed single and multi-organ microphysiological systems to improve the accuracy and efficiency of drug discovery, today announced a collaboration with Imperial College London, a world-class research university.

10 Sep 2020

Optibrium’s peer-reviewed study highlights the value of deep learning to impute drug discovery data

Optibrium, leading providers of software and services for drug discovery, today announced a peer-reviewed publication, ‘Practical Applications of Deep Learning to Impute Heterogeneous Drug Discovery Data’, in the Journal of Chemical Information and Modeling.

10 Sep 2020

Drug Discovery & Pharmaceuticals

Study offers explanation for why people's responses to the same drug vary widely

Calibr's novel 'switchable' CAR-T cell therapy granted FDA's Fast Track designation

Compounds repurposed from malaria treatment can kill diarrheal pathogen

Planaria flatworm can be used as reliable alternative for testing topical skin products

Researchers create drug-like compounds to destroy coronavirus' frameshifting element

Naturally occurring enzyme holds potential as low-cost therapeutic to treat COVID-19

Researchers develop a new substance that can disarm tumor-promoting proteins

Valproic acid can interact with DNA conformation and regulate gene expression

AXT add Vieworks bio-imaging solutions to their preclinical imaging portfolio

Quantum simulators could help create tomorrow's pharmaceuticals

New T-cell-based vaccine strategy provides broader protection against seasonal influenza

Researchers identify a potential drug candidate for hand, foot and mouth disease

Nanoparticle SARS-CoV-2 model could potentially speed the search for drugs

Ziath introduces new products to assist compound management labs using Acoustix tubes

RUDN geneticist finds a bifidobacterial protein that can reduce inflammation in COVID-19

Tiny antibody component shows high potency in SARS-CoV-2 animal models

New bone-on-a-chip device could revolutionize pharmaceutical pre-clinical testing

Cell signaling research rings warning bells over an emerging cancer drug target

CN Bio partners with Imperial College London to uncover therapeutic targets for alcoholic hepatitis

Optibrium’s peer-reviewed study highlights the value of deep learning to impute drug discovery data

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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