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Use of the antibiotic amoxicillin during infancy appears to be linked to tooth enamel defects in permanent teeth

Dental fluorosis, a result of exposure to excessive fluoride during enamel formation, is one of the most common developmental enamel defects, according to background information in the article.

4 Oct 2005

First time a protein serving as a template for DNA synthesis seen

Since the discovery of the structure of DNA by James Watson and Francis Crick in 1953, the paradigm for DNA replication has stated that the DNA itself codes for the appropriate pairings for replication.

3 Oct 2005

Landmark study aims to find genetic link to Alzheimer's disease

More than 500 families affected by Alzheimer's Disease are participating in a landmark study led by Columbia University Medical Center to find a genetic link to the disease. That number will now double to 1,000 under a new $10 million five-year grant from National Institute on Aging.

3 Oct 2005

Brain mechanism may play a central role in regulating anxiety and alcohol-drinking

The finding, by researchers supported by the National Institute on Alcohol Abuse and Alcoholism (NIAAA), part of the National Institutes of Health (NIH), could provide important clues about the neurobiology of alcohol-drinking behaviors in humans.

3 Oct 2005

Beta glucan may help treat skin disorders and remove fine lines and wrinkles

The fight against aging has received a scientific boost thanks to an innovative study done in part by a University of Alberta spin-off company--research that dispels a hard-held belief about the natural ingredient, beta glucan.

3 Oct 2005

Potential biomarker that could be used to predict who might develop hepatic fibrosis

Two new studies on Hepatitis C (HCV) patients who underwent liver transplants examined a potential biomarker that could be used to predict who might develop hepatic fibrosis, a formation of scar-like tissue that can lead to cirrhosis.

3 Oct 2005

Important developmental link between the cerebrum and the cerebellum

Higher cognitive functions, like language and visual processing, have long been thought to reside primarily in the brain's cerebrum. But a body of research in premature infants at Children's Hospital Boston is documenting an important role for the cerebellum

3 Oct 2005

Greasing the gears that drive the interferon signal

Interferon -- a critical protein that mediates the body's defense against a wide variety of infectious agents and tumors -- may soon have greater therapeutic value as the result of a new study by researchers at Washington University School of Medicine in St. Louis.

3 Oct 2005

Study shows that high-fat diets correlate to a chronic inflammatory state in the liver,

Mice that were fed diets high in fat and sugar developed immune system abnormalities in their livers, including reduced numbers of natural killer T (NKT) cells. These diet-related changes may contribute to obesity-related liver disease, according to a new study.

3 Oct 2005

Potential beneficial effect of copper orotate

As one of the services for patients with Alzheimer's disease, the Department of Psychiatry at the Saarland University Medical Center offers participation in a clinical phase II trial. This clinical trial aims to elucidate a potential beneficial effect of copper orotate (an organic copper salt), which is given together with a standard cholinesterase inhibitor.

3 Oct 2005

Ubiquitin ligase Rnf6 may be involved in oncogenesis

In a recent study, Dr. Ingolf Bach and colleagues from the University of Massachusetts Medical School, Worcester and the University of Hamburg describe a novel role for the ubiquitin/proteosome protein degradation pathway in the regulation of local actin dynamics in neurons.

3 Oct 2005

Steroids significantly reduce heart damage in children with Kawasaki's disease

When added to standard treatment, steroids significantly reduce the odds of developing heart damage in children with Kawasaki's disease, according to a study in the October issue of Pediatrics. These findings address a gap in knowledge.

3 Oct 2005

Misoprostol could play an important part in reducing complications of delivery in developing countries

A relatively cheap and easy to use drug could save the lives of thousands of women in the developing world, according to a study in this week's British Medical Journal.

3 Oct 2005

First identification of the genetic basis of disease in a patient with a complex I assembly defect

Mitochondrial complex I deficiency is one of the most common defects in patients with mitochondrial disease. The deficiency results from a failure to assemble the enzyme properly, but the nature of the molecular chaperones that are necessary for this process in mammals have remained obscure.

3 Oct 2005

Microarray technology may help tailor breast cancer therapy

Microarray technology could be used to tailor therapy according to the individual, and prevent breast cancer patients from having to undergo painful unsuccessful therapies.

3 Oct 2005

Speeding up fetal MRIs

A modified technique that uses the eyes as the line of reference means a 50 percent reduction in the time necessary to take MRI images of the fetal brain.

3 Oct 2005

Concerta, a once-daily form of the drug methylphenidate, successfully controlled ADHD symptoms

A new study has found that an all-day, extended-release stimulant for treating attention-deficit hyperactivity disorder (ADHD) remains effective for up to two years without significant side effects.

3 Oct 2005

Attitudes of a peer group are more influential than a group that is not as closely allied

According to a study at Yale, one of the most effective ways to change negative attitudes about obese people is by addressing perceptions of normative beliefs within particular social groups.

3 Oct 2005

Physical activity may reduce gastrointestinal symptoms in people who are obese

In a study published in the American Gastroenterological Association (AGA) journal Clinical Gastroenterology and Hepatology, researchers found that a high body mass index (BMI) and lack of physical activity were associated with an increase in GI symptoms such as stomach pain, diarrhea, constipation and irritable bowel syndrome (IBS).

3 Oct 2005

No specific antiretroviral drug-related "Crix belly" syndrome

Contrary to the concerns of many HIV-infected patients, there appears to be no specific antiretroviral drug-related "syndrome" of changes in body fat distribution in men wherein leg and arm fat decrease as belly fat increases, reports a study in the October issue of Journal of Acquired Immune Deficiency Syndromes (JAIDS).

28 Sep 2005

Drug Trial News

Use of the antibiotic amoxicillin during infancy appears to be linked to tooth enamel defects in permanent teeth

First time a protein serving as a template for DNA synthesis seen

Landmark study aims to find genetic link to Alzheimer's disease

Brain mechanism may play a central role in regulating anxiety and alcohol-drinking

Beta glucan may help treat skin disorders and remove fine lines and wrinkles

Potential biomarker that could be used to predict who might develop hepatic fibrosis

Important developmental link between the cerebrum and the cerebellum

Greasing the gears that drive the interferon signal

Study shows that high-fat diets correlate to a chronic inflammatory state in the liver,

Potential beneficial effect of copper orotate

Ubiquitin ligase Rnf6 may be involved in oncogenesis

Steroids significantly reduce heart damage in children with Kawasaki's disease

Misoprostol could play an important part in reducing complications of delivery in developing countries

First identification of the genetic basis of disease in a patient with a complex I assembly defect

Microarray technology may help tailor breast cancer therapy

Speeding up fetal MRIs

Concerta, a once-daily form of the drug methylphenidate, successfully controlled ADHD symptoms

Attitudes of a peer group are more influential than a group that is not as closely allied

Physical activity may reduce gastrointestinal symptoms in people who are obese

No specific antiretroviral drug-related "Crix belly" syndrome

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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