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Unique therapeutic strategy to combat cachexia

Researchers at Oregon Health & Science University's Doernbecher Children's Hospital have uncovered a unique therapeutic strategy to combat cachexia - severe malnutrition and physical wasting away - in children and adults with chronic kidney disease (CKD). The study is published in the June issue of the Journal of Clinical Investigation.

9 Jun 2005

Giving individuals with single or infrequent seizures immediate treatment does not reduce their risk of seizure recurrence in the long-term

Between 1993 and 2000, David Chadwick (University of Liverpool, UK) and colleagues, recruited around 1400 patients with single or infrequent seizures from centres in the UK and around the world.

9 Jun 2005

Similarities in antiretroviral therapy efficacy in poorer countries to that in industrial nations

Antiretroviral therapy (ART) programs for treating HIV in developing countries are about as effective as ART programs in developed countries, according to an article in the July 15 issue of Clinical Infectious Diseases, now available online.

9 Jun 2005

Commonly used painkillers for treating inflammation may increase the risk of heart attack

Patients should not stop taking the drugs involved - non-steroidal anti-inflammatory drugs (NSAIDS) - but further investigation into these treatments is needed, say the authors.

9 Jun 2005

Molecule called Smad7 may open doors to future treatments in pancreatic and other forms of cancer

Making new strides in their ongoing effort to understand mechanisms behind the relentless growth of cancer cells, researchers at Dartmouth Medical School have found a promising key that may open doors to future treatments in pancreatic and other forms of cancer.

9 Jun 2005

Study of glial cells in the roundworm C. elegans may provide insight into a variety of human brain diseases

The key to understanding our brains may lie within a one-millimeter long worm, new research from Rockefeller University indicates. Reporting in the June issue of Developmental Cell, Shai Shaham, Ph.D., and graduate student Elliot Perens use the roundworm, C. elegans, to investigate the mysterious glial cell, which makes up 90 percent of the human brain and, when it malfunctions, can contribute to diseases like Parkinson's disease and schizophrenia.

9 Jun 2005

Healthy neighborhoods for older adults subject of study

Doctors often advise their older patients to walk more to enhance their health, but what if the sidewalks are crumbling; if they don't know a neighbor who could serve as a walking partner to help them feel safe; or if there's nothing interesting to see outside of their homes?

9 Jun 2005

Doctors and patients think differently about clinical trials

A survey of patients and physicians regarding clinical trials shows that doctors don't recognize the importance of side effects as a barrier for their patients in deciding about whether to undergo experimental therapy.

9 Jun 2005

Designed drug for combined hormone and chemotherapy treatment

The search for new drugs to fight cancer remains at the top of the to do list for pharmaceutical researchers. A recent variation is polymer chemotherapy agents, drugs that have been attached to a "backbone" of long chain molecules.

9 Jun 2005

Association between chronic cytomegalovirus (CMV) and frailty syndrome

Older women with chronic cytomegalovirus (CMV), a lifelong viral infection, were found to have more than triple the risk of being frail than those who did not have the infection, as reported in the Journal of the American Geriatrics Society. This is the first demonstration to show an association between CMV and frailty syndrome.

9 Jun 2005

Multisequential MRI approach improves heart inflammation diagnosis

A multisequential approach to cardiovascular magnetic resonance scans that highlight different aspects of heart structure and function may offer a better and safer way to identify potentially deadly inflammation of the heart muscle, according to a new study (PDF) in the June 7, 2005, issue of the Journal of the American College of Cardiology.

9 Jun 2005

Study raises questions about food products meant to block cholesterol absorption

Plant sterols, which are naturally found in many foods but are also added to some foods intended to inhibit cholesterol absorption, are present in artery plaques, according to a new study (PDF) in the June 7, 2005, issue of the Journal of the American College of Cardiology.

9 Jun 2005

MabThera highly effective in treating rheumatoid arthritis

Results from the DANCER study presented today revealed that MabThera significantly improves symptoms in heavily treated patients who are affected by moderate-to-severe rheumatoid arthritis (RA), a painful and debilitating disease of the joints.

9 Jun 2005

Modifying your salt intake has the potential to prevent exercise-induced asthma

An Indiana University professor may have uncovered the mechanisms by which high-salt diets can trigger exercise-induced asthma, offering the most complete picture to date of how dietary factors can both aggravate and alleviate the symptoms of this common condition.

9 Jun 2005

Rheumatoid arthritis costs more to business and industry than almost any other disease

Speaking at a rheumatology congress in Vienna today (Thursday 9 June), USA experts estimated that RA costs employers over $4,000 more per person, per year.

9 Jun 2005

Rituximab, used to treat rheumatoid arthritis (RA) is safe and effective

Professor Paul Emery from the University of Leeds in the UK led the DANCER study (Double blind placebo controlled dose ranging study), designed to confirm the efficacy of rituximab for the treatment of patients with active RA who have failed to improve on one or more disease modifying anti-rheumatic drugs (DMARDs).

9 Jun 2005

New study shows tiny RNAs intimately associated with cancer

In discoveries that may open a new chapter in understanding and diagnosing cancer, Howard Hughes Medical Institute (HHMI) investigators and their colleagues have established that tiny microRNAs provide a novel genetic route to the initiation of some forms of cancer.

9 Jun 2005

Rituximab provides new hope for people with lupus

Rheumatologists at the Annual European Congress of Rheumatology in Vienna, Austria heard today (Thursday 9 June) that rituximab is the first drug in a quarter of a century that is making a real impact, and an alternative to previous standard treatments of high-dose steroids, and chemotherapy.

9 Jun 2005

Missing link between mothers' diets and obesity in kids

New work may have found the missing link between mothers' diets and obesity in kids. A study published in the June issue of Cell Metabolism suggests that a hormone may explain the connection between mothers who are poorly nourished and an increased risk of obesity in their children.

8 Jun 2005

Adults with diabetes at higher risk for cardiovascular problems due air pollution

Researchers from the Harvard School of Public Health and colleagues assessed the effect of high air pollution levels, specifically emissions from coal-burning power plants and diesel vehicles, on Boston-area adults with diabetes.

8 Jun 2005

Drug Trial News

Unique therapeutic strategy to combat cachexia

Giving individuals with single or infrequent seizures immediate treatment does not reduce their risk of seizure recurrence in the long-term

Similarities in antiretroviral therapy efficacy in poorer countries to that in industrial nations

Commonly used painkillers for treating inflammation may increase the risk of heart attack

Molecule called Smad7 may open doors to future treatments in pancreatic and other forms of cancer

Study of glial cells in the roundworm C. elegans may provide insight into a variety of human brain diseases

Healthy neighborhoods for older adults subject of study

Doctors and patients think differently about clinical trials

Designed drug for combined hormone and chemotherapy treatment

Association between chronic cytomegalovirus (CMV) and frailty syndrome

Multisequential MRI approach improves heart inflammation diagnosis

Study raises questions about food products meant to block cholesterol absorption

MabThera highly effective in treating rheumatoid arthritis

Modifying your salt intake has the potential to prevent exercise-induced asthma

Rheumatoid arthritis costs more to business and industry than almost any other disease

Rituximab, used to treat rheumatoid arthritis (RA) is safe and effective

New study shows tiny RNAs intimately associated with cancer

Rituximab provides new hope for people with lupus

Missing link between mothers' diets and obesity in kids

Adults with diabetes at higher risk for cardiovascular problems due air pollution

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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