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EMA grants PRIME designation to Themis' chikungunya vaccine candidate

Themis announced today that the European Medicines Agency has granted PRIority MEdicines designation to its most advanced program in development, a vaccine to prevent chikungunya fever.

11 Jun 2018

Alnylam announces new positive results from Phase 1/2 study of lumasiran in patients with PH1

Alnylam Pharmaceuticals, Inc., the leading RNAi therapeutics company, announced today new positive results from its Phase 1/2 study with lumasiran, an investigational RNAi therapeutic targeting glycolate oxidase for the treatment of Primary Hyperoxaluria Type 1.

8 Jun 2018

Esophageal cancer risk could be reduced by esomeprazole and low dose aspirin

According to the results of a phase III trial presented at the 2018 ASCO Annual Meeting, two simple over-the-counter medicines – high dose esomeprazole and low dose aspirin when taken regularly can moderately lessen the risk of high grade esophageal cancer in patients who are diagnosed with Barrett’s esophagus when taken for at least 7 years.

5 Jun 2018

MiNA Therapeutics announces initial results from phase I trial of saRNA candidate in liver cancer patients

MiNA Therapeutics, the pioneer in RNA activation therapeutics, today announced preliminary results from its ongoing Phase I study of small activating RNA candidate MTL-CEBPA in advanced liver cancer.

4 Jun 2018

Protein inhibitor drug found to be safe and effective in treating patients with acute myeloid leukemia

Ivosidenib, an experimental drug that inhibits a protein often mutated in several cancers has been shown to be safe, resulting in durable remissions, in a study of acute myeloid leukemia with relapsed or refractory disease.

4 Jun 2018

Phase I trial shows safety of investigational drug in treating chronic lymphocytic leukemia

Reporting results from a first-in-human phase I clinical trial, researchers at University of California San Diego School of Medicine have found that treatment with cirmtuzumab, an experimental monoclonal antibody-based drug, measurably inhibited the "stemness" of chronic leukemia cancer cells - their ability to self-renew and resist terminal differentiation and senescence.

1 Jun 2018

Opdivo plus low-dose Yervoy shows promising results in treating renal cell carcinoma patients

Bristol-Myers Squibb Company today announced patient-reported outcomes data from the Phase 3 CheckMate -214 trial in intermediate- and poor-risk patients with advanced renal cell carcinoma treated with the Immuno-Oncology combination Opdivo plus low-dose Yervoy versus sunitinib over a two-year follow-up period.

1 Jun 2018

New trial to test if omega-3 capsules can stop secondary liver cancer recurrence after surgery

A new clinical trial from the University of Leeds is testing omega-3 capsules in patients who have bowel cancer which has spread to the liver, to see if it can stop the cancer returning after surgery.

30 May 2018

Fewer women meet eligibility criteria for clinical trial of heart failure drugs, study finds

Clinical trial enrolment favors men, according to a study presented today at Heart Failure 2018 and the World Congress on Acute Heart Failure, a European Society of Cardiology congress. The study found that fewer women meet eligibility criteria for trials of heart failure medication.

28 May 2018

Researchers find novel ways to improve participation in clinical research

Videos and creative uses of other visuals provide a novel way to obtain informed consent during clinical trials to improve participants' understanding and retention of trial information, according to a study by Nemours Children's Health System presented at the American Thoracic Society (ATS) Annual Conference.

25 May 2018

Bath geriatrician leads new UK-wide trial into Parkinson’s disease

It will test whether a commonly prescribed dementia drug could prevent debilitating falls for people with the disease. Falls are a frequent complication of Parkinson's, which affect around 60 percent of the 127,000-people diagnosed with the condition each year.

24 May 2018

Antioxidant-enriched multivitamin may decrease respiratory illnesses in CF patients, finds study

Researchers at Children's Hospital Colorado and the University of Colorado School of Medicine have found that taking a specially formulated antioxidant-enriched multivitamin may decrease respiratory illnesses in people with cystic fibrosis.

24 May 2018

NIH commences first-in-human trial evaluating experimental treatment for Ebola

A first-in-human trial evaluating an experimental treatment for Ebola virus disease has begun at the National Institutes of Health (NIH) Clinical Center in Bethesda, Maryland.

24 May 2018

PanOptica doses first patient in Phase 1/2 dose-ranging clinical trial of PAN-90806

PanOptica, Inc., a private biopharmaceutical company focused on developing innovative ophthalmology therapies, today announced that the Company has dosed the first patient in a Phase 1/2 dose-ranging clinical trial of PAN-90806, a once-daily topical eye drop formulation of a small-molecule anti-vascular endothelial growth factor (anti-VEGF) for the treatment of neovascular eye diseases.

22 May 2018

Investigational drug offers hope of relief for celiac disease patients exposed to gluten

An investigational new drug offers hope of relief for celiac disease patients who are inadvertently exposed to gluten while on a gluten-free diet.

22 May 2018

Researchers to test two-pronged approach in humans to treat advanced colorectal cancer

For the first time in humans, researchers will test a two-pronged approach to treat advanced stage colorectal cancer, potentially increasing life expectancy.

22 May 2018

Pfizer starts Phase 1/2 study of RSV vaccine candidate in healthy adult volunteers

Pfizer Inc. today announced that it has started a Phase 1/2 trial of its respiratory syncytial virus (RSV) vaccine candidate in healthy adult volunteers. RSV is a common respiratory virus that affects the lungs and airways, with significant impact on young children and older adults.

22 May 2018

Clinical trial begins enrollment to test safety of experimental MERS treatments

Enrollment has begun in an early-stage clinical trial testing the safety of two human monoclonal antibodies (mAbs) designed to treat people infected with Middle East respiratory syndrome coronavirus (MERS-CoV).

18 May 2018

Pfizer announces Phase 3 study results of LYRICA Oral Solution CV for pediatric epilepsy patients

Pfizer Inc. announced today positive top-line results of a Phase 3 study examining the use of LYRICA® Oral Solution CV as adjunctive therapy for partial onset seizures in pediatric epilepsy patients one month to less than four years of age.

17 May 2018

Alexo Therapeutics marks next significant milestone by initiating ALX148 combination cohorts

Alexo Therapeutics, a clinical-stage immuno-oncology company developing therapies to block the CD47 checkpoint mechanism, today announced it has initiated ALX148 combination dosing with targeted antibody therapies in its Phase 1 clinical program in patients with advanced solid tumors and lymphoma.

17 May 2018

Drug Trial News

EMA grants PRIME designation to Themis' chikungunya vaccine candidate

Alnylam announces new positive results from Phase 1/2 study of lumasiran in patients with PH1

Esophageal cancer risk could be reduced by esomeprazole and low dose aspirin

MiNA Therapeutics announces initial results from phase I trial of saRNA candidate in liver cancer patients

Protein inhibitor drug found to be safe and effective in treating patients with acute myeloid leukemia

Phase I trial shows safety of investigational drug in treating chronic lymphocytic leukemia

Opdivo plus low-dose Yervoy shows promising results in treating renal cell carcinoma patients

New trial to test if omega-3 capsules can stop secondary liver cancer recurrence after surgery

Fewer women meet eligibility criteria for clinical trial of heart failure drugs, study finds

Researchers find novel ways to improve participation in clinical research

Bath geriatrician leads new UK-wide trial into Parkinson’s disease

Antioxidant-enriched multivitamin may decrease respiratory illnesses in CF patients, finds study

NIH commences first-in-human trial evaluating experimental treatment for Ebola

PanOptica doses first patient in Phase 1/2 dose-ranging clinical trial of PAN-90806

Investigational drug offers hope of relief for celiac disease patients exposed to gluten

Researchers to test two-pronged approach in humans to treat advanced colorectal cancer

Pfizer starts Phase 1/2 study of RSV vaccine candidate in healthy adult volunteers

Clinical trial begins enrollment to test safety of experimental MERS treatments

Pfizer announces Phase 3 study results of LYRICA Oral Solution CV for pediatric epilepsy patients

Alexo Therapeutics marks next significant milestone by initiating ALX148 combination cohorts

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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