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Case study: Experimental lecanemab treatment causes adverse outcomes in 65-year-old woman with Alzheimer's disease

In a noteworthy case study published in the Journal of Alzheimer's Disease investigators report autopsy findings in a 65-year-old woman with Alzheimer's disease (AD) who received three open label infusions of the experimental anti-amyloid beta (Aβ) antibody drug lecanemab.

25 May 2023

Mays Cancer Center conducts clinical trial combining two drugs in patients with recurrent, high-grade glioblastoma

The Mays Cancer Center at The University of Texas Health Science Center at San Antonio recently conducted a clinical trial combining two drugs in patients with recurrent, high-grade glioblastoma (GBM).

24 May 2023

What is the efficacy, safety, and tolerability of novel danuglipron in adults with type two diabetes?

Researchers assessed the safety and efficacy of danuglipron in type 2 diabetes (T2D) patients.

24 May 2023

International clinical trial to evaluate new combinations of generic antibiotics for treating neonatal sepsis

An international clinical trial co-led by UCL (University College London) researchers will evaluate much-needed new antibiotic combinations for newborn babies with sepsis.

23 May 2023

First vaccine against Lyme disease is now being tested in Sweden

A vaccine against Lyme disease is now being tested in Sweden, for the first time ever. A new vaccine will probably be on the market within a couple of years, says Johan Sanmartin Berglund, Professor of applied health technology at Blekinge Institute of Technology.

23 May 2023

Amyloid-removing drug shows promise for the treatment of stiff-heart syndrome

Transthyretin-related cardiac amyloidosis is a progressive disease characterized by the deposition of amyloid protein fibrils in the heart. Amyloid fibril deposition thickens and stiffens the heart walls, and the disease is also known as stiff-heart syndrome.

22 May 2023

New clinical trial gets underway to evaluate new antibiotic combinations for newborns with sepsis

An international clinical trial to evaluate much-needed new antibiotic combinations for newborn babies with sepsis has started in three public hospitals in South Africa and Kenya.

22 May 2023

Study shows potential benefit of sacubitril/valsartan in heart failure patients with EF over 40%

Sacubitril/valsartan leads to greater reduction in plasma NT-proBNP levels compared to valsartan alone after stabilization for worsening heart failure in patients with an ejection fraction (EF) above 40%, according to late breaking science presented today at Heart Failure 2023, a scientific congress of the European Society of Cardiology (ESC), and published in the Journal of the American College of Cardiology.

22 May 2023

Multicenter, 1-year-long real-world study shows effectiveness of semaglutide for weight loss

New research presented at this year's European Congress on Obesity (ECO2023, Dublin, 17-20 May) shows that the obesity drug semaglutide is effective for weight loss in a multicentre, 1-year-long real-world study.

22 May 2023

TWILIGHT trial reveals the impact of DAPT and ticagrelor monotherapy after percutaneous coronary intervention

New insights from the TWILIGHT trial showed that ticagrelor monotherapy after three months of ticagrelor plus aspirin was associated with similar rates of recurrent coronary revascularization, major adverse cardiac and cerebrovascular events (MACCE) and a lower risk of net adverse clinical events (NACE) compared with duel antiplatelet therapy (DAPT).

19 May 2023

Valbenazine improves chorea associated with Huntington's disease

The drug valbenazine statistically improves chorea, a movement disorder commonly associated with Huntington's disease, when compared to a placebo, according to a recent international study led by UTHealth Houston researcher Erin Furr Stimming, MD, who served as principal investigator on behalf of the KINECT-HD Huntington Study Group.

19 May 2023

Tirzepatide improves body composition across a range of adult age groups, study shows

A new analysis of SURMOUNT-1, the first Phase 3 study of tirzepatide in adults for chronic weight management shows that tirzepatide improves body composition across a range of adult age groups.

19 May 2023

Majority of people in the UK would consider taking part in a clinical trial, survey reveals

The majority of people in the UK (68%) would consider taking part in a clinical trial, it has been revealed today (19 May), while half of Brits would also be willing to take part in an early phase clinical trial.

18 May 2023

Clinical trial shows efficacy and safety of brepocitinib for treating adults with psoriatic arthritis

Brepocitinib is an oral drug that inhibits certain enzymes involved in inflammation-;called tyrosine kinase 2 and Janus kinase 1-;and is being tested for the treatment of several immunological diseases.

17 May 2023

Nemours Children's Health selected to conduct first gene therapy clinical trial for Morquio A syndrome

As part of the Foundation for the National Institutes of Health Accelerating Medicines Partnership Bespoke Gene Therapy Consortium, Nemours Children's Health has been chosen to conduct a first-of-its-kind gene therapy clinical trial for Morquio A syndrome.

16 May 2023

Clinical trial of a combination treatment shows great promise for patients with glioblastoma

A new international study published in Nature Medicine and presented as a late-breaking abstract at the American Association of Neurological Surgeons annual conference, shows great promise for patients with glioblastoma.

15 May 2023

Phase 1 trial of experimental universal influenza vaccine begins enrolling volunteers

A clinical trial of an experimental universal influenza vaccine developed by researchers at the National Institute of Allergy and Infectious Diseases' (NIAID) Vaccine Research Center (VRC), part of the National Institutes of Health, has begun enrolling volunteers at Duke University in Durham, North Carolina.

15 May 2023

Cyclical estrogen/anti-estrogen therapy could be a promising strategy to treat metastatic ER+ breast cancer

Advanced or metastatic estrogen receptor-positive (ER+) breast cancer is commonly treated with drugs that block the estrogen receptor.

15 May 2023

Phase 1 clinical trial of CAR-NKT cell therapy shows promising results in neuroblastoma patients

Researchers at Baylor College of Medicine/Texas Children's Cancer Center and collaborating institutions report interim results from a first-in-human phase 1 clinical trial evaluating the safety, antitumor activity and immunological characteristics of a genetically engineered natural killer T (NKT) cell immunotherapy for neuroblastoma, a childhood tumor that most commonly arises in the adrenal gland.

15 May 2023

Combination approach is safe, improves survival outcomes in a subset of glioblastoma patients

Intratumoral delivery of an engineered oncolytic virus (DNX-2401) targeting glioblastoma (GBM) cells combined with subsequent immunotherapy was safe and improved survival outcomes in a subset of patients with recurrent GBM, according to results from a multi-institutional Phase I/II clinical trial co-led by researchers at The University of Texas MD Anderson Cancer Center and the University of Toronto.

15 May 2023

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Drug Trial News

Case study: Experimental lecanemab treatment causes adverse outcomes in 65-year-old woman with Alzheimer's disease

Mays Cancer Center conducts clinical trial combining two drugs in patients with recurrent, high-grade glioblastoma

What is the efficacy, safety, and tolerability of novel danuglipron in adults with type two diabetes?

International clinical trial to evaluate new combinations of generic antibiotics for treating neonatal sepsis

First vaccine against Lyme disease is now being tested in Sweden

Amyloid-removing drug shows promise for the treatment of stiff-heart syndrome

New clinical trial gets underway to evaluate new antibiotic combinations for newborns with sepsis

Study shows potential benefit of sacubitril/valsartan in heart failure patients with EF over 40%

Multicenter, 1-year-long real-world study shows effectiveness of semaglutide for weight loss

TWILIGHT trial reveals the impact of DAPT and ticagrelor monotherapy after percutaneous coronary intervention

Valbenazine improves chorea associated with Huntington's disease

Tirzepatide improves body composition across a range of adult age groups, study shows

Majority of people in the UK would consider taking part in a clinical trial, survey reveals

Clinical trial shows efficacy and safety of brepocitinib for treating adults with psoriatic arthritis

Nemours Children's Health selected to conduct first gene therapy clinical trial for Morquio A syndrome

Clinical trial of a combination treatment shows great promise for patients with glioblastoma

Phase 1 trial of experimental universal influenza vaccine begins enrolling volunteers

Cyclical estrogen/anti-estrogen therapy could be a promising strategy to treat metastatic ER+ breast cancer

Phase 1 clinical trial of CAR-NKT cell therapy shows promising results in neuroblastoma patients

Combination approach is safe, improves survival outcomes in a subset of glioblastoma patients

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Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

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