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Lenacapavir: A breakthrough in long-acting HIV prevention for cisgender women

The injectable antiretroviral drug lenacapavir was safe and 100% effective as long-acting HIV pre-exposure prophylaxis (PrEP) among cisgender women in a Phase 3 clinical trial, according to top-line findings released by Gilead Sciences, Inc., the study sponsor.

26 Jun 2024

Semaglutide reduces heart risks in overweight and obese individuals without diabetes

The SELECT trial found that semaglutide significantly reduces cardiovascular events in individuals with overweight or obesity and preexisting cardiovascular disease, regardless of baseline HbA1c or changes in HbA1c levels.

26 Jun 2024

Extended-release ketamine tablets offer new hope for treatment-resistant depression

The BEDROC trial found that extended-release ketamine tablets (R-107) significantly improve depressive symptoms in treatment-resistant depression patients, with the 180 mg dose showing the most efficacy. The treatment was well-tolerated with minimal side effects.

26 Jun 2024

New curative treatment for sickle cell disease shows promising results in international trial

Vanderbilt University Medical Center (VUMC) researchers are touting data from a multicenter, international phase 2 clinical trial showing a new, curative treatment for sickle cell disease (SCD).

25 Jun 2024

New ketamine slow-release tablet shows promise in treating severe depression

A new tablet form of ketamine has shown promise in treating severe depression, offering a potential alternative to existing clinic-based treatments that can be expensive and lacking in convenience for some patients.

24 Jun 2024

Ketamine tablets offer new hope for treatment-resistant depression

For those suffering from treatment-resistant depression, the anaesthetic drug ketamine offers hope, but it has side effects and can be costly to access – a University of Otago-led clinical trial may change that.

24 Jun 2024

Novo Nordisk presents key findings from semaglutide trials at ADA scientific sessions 2024

Novo Nordisk today announced the presentation of 34 abstracts highlighting the breadth of its portfolio at the upcoming 84th Scientific Sessions of the American Diabetes Association (ADA).

22 Jun 2024

Anakinra shows promise in reducing symptoms in patients with Sanfilippo syndrome

As a neurodegenerative disease characterized by childhood onset dementia, Sanfilippo syndrome causes immense suffering in many ways, including pain, loss of speech, extreme agitation, and distress, gastrointestinal symptoms, and profound sleep disturbance.

21 Jun 2024

Repurposing anti-retroviral medications for brain tumor treatment: The RETREAT trial

Drugs developed to combat HIV and AIDS are being trialed for the first time in patients with multiple brain tumors.

21 Jun 2024

Study: Anti-inflammatory drug celecoxib benefits PIK3CA-mutated colon cancer patients

An analysis of data from a randomized clinical trial for patients with stage 3 colon cancer found that those with PIK3CA mutations who took celecoxib, an anti-inflammatory drug, after surgery lived significantly longer and had longer disease-free survival compared to those without the mutation.

18 Jun 2024

Nicotinamide riboside boosts walking endurance in peripheral artery disease

The over-the-counter supplement nicotinamide riboside, a form of vitamin B3, increased the walking endurance of patients with peripheral artery disease, a chronic leg condition for which there are few effective treatments.

18 Jun 2024

Global study confirms pantoprazole's role in reducing upper GI bleeding in the ICU

A widely available drug helps prevent upper gastrointestinal bleeding in critically ill adults on a breathing machine, according to the results of a global study and meta-analysis led by researchers at McMaster University.

14 Jun 2024

MEK inhibitor trametinib shows potential in pediatric JMML treatment

The MEK inhibitor trametinib (Mekinist) was an effective treatment for pediatric patients with relapsed or refractory juvenile myelomonocytic leukemia (JMML) enrolled in a phase II clinical trial, with seven of 10 patients alive after a median of two years.

13 Jun 2024

First-in-human trial shows safety and efficacy of CAR T cell therapy for advanced prostate cancer

Treating prostate cancer with immunotherapy is currently difficult to do. But results from a first in-human phase 1 trial using a chimeric antigen receptor (CAR) T cell therapy developed by researchers from City of Hope, one of the largest cancer research and treatment organizations in the United States, showed that patients with advanced prostate cancer can be treated safely with the cellular immunotherapy with promising therapeutic activity, according to the phase 1 trial study published today in Nature Medicine.

12 Jun 2024

Crinecerfont: A promising compound for reducing corticosteroid dependence in CAH patients

People born with the common form of congenital adrenal hyperplasia lack an enzyme in the adrenal glands needed to make the hormones cortisol and aldorsterone, which are involved in the body's response to stress and blood pressure regulation.

10 Jun 2024

Clinical trial demonstrates efficacy of two-drug therapy for methamphetamine addiction

A clinical trial on a two-drug therapy for methamphetamine use disorder reduced use of the highly addictive drug for up to 12 weeks after initiation of treatment, UCLA-led research suggests.

10 Jun 2024

Stanford study finds 15-day paxlovid treatment safe but ineffective for long COVID

In a clinical trial conducted by Stanford Medicine investigators and their colleagues, a 15-day course of Paxlovid -; an antiviral drug combination targeting SARS-CoV-2, the virus that causes COVID-19 -; proved safe as an extended-duration treatment but didn't lessen select symptoms of the syndrome known as long COVID: the persistence, or reappearance, of COVID-related symptoms three months or more after an initial COVID-19 infection.

7 Jun 2024

New hope for BCG-unresponsive bladder cancer patients with innovative combination therapy

In a groundbreaking advance that could revolutionize bladder cancer treatment, a novel combination of cretostimogene grenadenorepvec and pembrolizumab has shown remarkable efficacy in patients with Bacillus Calmette-Guérin (BCG)-unresponsive non-muscle invasive bladder cancer.

6 Jun 2024

Phase III trial highlights benefits of intensity modulated proton therapy for oropharyngeal cancer

According to preliminary data from a multi-institution Phase III trial led by researchers at The University of Texas MD Anderson Cancer Center, intensity modulated proton therapy (IMPT) achieved similar clinical outcomes and offered significant patient benefits when compared to traditional intensity modulated radiation therapy (IMRT) as part of chemoradiation treatment for patients with oropharyngeal (head and neck) cancer.

6 Jun 2024

New bilateral gene therapy shows promising results in treating genetic hearing loss

A novel gene therapy designed to target a form of inherited deafness restored hearing function in five children who were treated in both ears.

5 Jun 2024

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Drug Trial News

Lenacapavir: A breakthrough in long-acting HIV prevention for cisgender women

Semaglutide reduces heart risks in overweight and obese individuals without diabetes

Extended-release ketamine tablets offer new hope for treatment-resistant depression

New curative treatment for sickle cell disease shows promising results in international trial

New ketamine slow-release tablet shows promise in treating severe depression

Ketamine tablets offer new hope for treatment-resistant depression

Novo Nordisk presents key findings from semaglutide trials at ADA scientific sessions 2024

Anakinra shows promise in reducing symptoms in patients with Sanfilippo syndrome

Repurposing anti-retroviral medications for brain tumor treatment: The RETREAT trial

Study: Anti-inflammatory drug celecoxib benefits PIK3CA-mutated colon cancer patients

Nicotinamide riboside boosts walking endurance in peripheral artery disease

Global study confirms pantoprazole's role in reducing upper GI bleeding in the ICU

MEK inhibitor trametinib shows potential in pediatric JMML treatment

First-in-human trial shows safety and efficacy of CAR T cell therapy for advanced prostate cancer

Crinecerfont: A promising compound for reducing corticosteroid dependence in CAH patients

Clinical trial demonstrates efficacy of two-drug therapy for methamphetamine addiction

Stanford study finds 15-day paxlovid treatment safe but ineffective for long COVID

New hope for BCG-unresponsive bladder cancer patients with innovative combination therapy

Phase III trial highlights benefits of intensity modulated proton therapy for oropharyngeal cancer

New bilateral gene therapy shows promising results in treating genetic hearing loss

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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