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New study identifies 17 genes driving clonal hematopoiesis in aging blood cells

Scientists have discovered 17 additional genes that drive the abnormal overgrowth of mutated blood cells as we age. The findings, published today (14 May) in Nature Genetics, provide a more complete view of the genetic factors behind clonal hematopoiesis – a process associated with ageing and linked to increased risks of blood cancers.

15 May 2024

More than 20,000 volunteers join effort to accelerate dementia drug development

More than 20,000 volunteers have been recruited to a resource aimed at speeding up the development of much-needed dementia drugs. The cohort will enable scientists in universities and industry to involve healthy individuals in clinical trials to test whether new drugs can slow the decline in various brain functions including memory and delay the onset of dementia.

15 May 2024

Oncotype DX Breast Recurrence Score test recommended by NICE for lymph node-positive breast cancer patients

Exact Sciences, a leading provider of cancer screening and diagnostic tests, today announced that the UK’s National Institute for Health and Care Excellence (NICE) has recommended the expanded use of the Oncotype DX Breast Recurrence Score® test to more effectively target chemotherapy treatment for women who have hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-), early-stage breast cancer involving up to three positive nodes and who have been through the menopause.

15 May 2024

Metabolomics study finds biomarkers predicting autism in newborns

A study in Communications Biology utilized metabolomics in newborns to identify markers that might predict autism spectrum disorder (ASD), finding distinct metabolic profiles in children with ASD compared to typically developing children.

14 May 2024

Sleep and anesthesia hinder brain toxin clearance, study reveals

Researchers found that brain clearance is reduced during both sleep and anesthesia, contradicting the belief that these states enhance toxin removal.

14 May 2024

Semaglutide shows significant weight loss and health benefits in four-year obesity study

A study in Nature Medicine evaluated the effects of semaglutide on weight and anthropometric outcomes in adults with obesity but without diabetes, finding significant weight loss and improved health metrics over four years. The study also highlighted the safety and tolerability of semaglutide across different BMI categories.

14 May 2024

Paddling through mental health: Long-term benefits of SUP revealed in "Freedom on Water" study

A study in the journal Healthcare highlights the significant long-term benefits of stand-up paddling (SUP) on mental health and well-being for individuals with mental disorders, as seen in the "Freedom on Water" project.

14 May 2024

St. Jude researchers unveil mechanisms to block PXR and enhance drug potency

Deaths from cancer or infections can occur when available treatments are ineffective. Once turned on, pregnane X receptor (PXR) activates the expression of genes encoding enzymes that metabolize external chemicals, including drugs.

14 May 2024

Innovative 'mini-brains' could revolutionize Alzheimer's diagnosis and treatment

Using an innovative new method, a University of Saskatchewan (USask) researcher is building tiny pseudo-organs from stem cells to help diagnose and treat Alzheimer's.

14 May 2024

New technique reveals brain cells age at different rates

Engineers at the University of California San Diego have discovered that some brain cells age more rapidly than others, and they are disproportionately abundant in individuals afflicted with Alzheimer's disease.

14 May 2024

Study proposes a novel therapeutic avenue for tackling EHF-induced cholangiocarcinogenesis

This study is led by Dr. Yiming Luo (Hepatic Surgery Centre, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology) and Professor. Huifang Liang (Hepatic Surgery Centre, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology).

14 May 2024

Researchers find beneficial effects of a novel drug in the management of myocardial infarction

Researchers from the Cardiac Regeneration and Heart Failure Research Group (ICREC) at the Germans Trias i Pujol Research Institute (IGTP) and the Heart Institute of the Germans Trias Hospital(iCor) have found beneficial effects of the novel drug Sacubitril/Valsartan in the management of myocardial infarction (MI).

14 May 2024

Pharmacological treatment reduces specific crimes in adolescents with ADHD

A study in the Journal of the American Academy of Child and Adolescent Psychiatry (JAACAP), published by Elsevier, found that pharmacological treatment of attention-deficit/hyperactivity disorder (ADHD) reduced violence- and public-order related crimes.

14 May 2024

New risk assessment tool developed for predicting outcomes in heart failure patients

UVA Health researchers have developed a powerful new risk assessment tool for predicting outcomes in heart failure patients. The researchers have made the tool publicly available for free to clinicians.

14 May 2024

Human cell-based model of thoracic aortic aneurysm offers new opportunities for drug development

Using human cells in laboratory rats, Michigan Medicine researchers have developed a functional model of thoracic aortic aneurysm, creating opportunities for more effective understanding of disease development and treatments for the potentially fatal condition, a study suggests.

14 May 2024

Racial and ethnic disparities in Alzheimer's diagnosis and CNS drug prescription

Compared to Black and Asian people, white and Hispanic people with Alzheimer's disease and related dementias were most likely to be diagnosed with symptoms like depression and agitation, according to a new study from the USC Schaeffer Center for Health Policy & Economics.

14 May 2024

Experts advocate for terminology change in brain injury research

A new editorial published this May in the British Journal of Sports Medicine by experts from Spaulding Rehabilitation, Boston University, Mayo Clinic, and the Concussion Legacy Foundation, argues that the term "subconcussion" is a dangerous misnomer that should be retired.

14 May 2024

Investigational drug shows promise in increasing oxygen uptake for patients with heart condition

People with a common heart condition were able to use significantly more oxygen while exercising after taking an investigational drug in an international clinical trial, according to a study published today in the New England Journal of Medicine.

14 May 2024

New joint guideline highlights importance of coordinated care for peripheral artery disease

Timely diagnosis and proper management of peripheral artery disease (PAD), including coordinated care from a multispecialty team, are essential to help prevent amputation and other cardiovascular complications and to allow patients with PAD to live longer lives with better physical function and improved quality of life, according to a new joint guideline published today in the American Heart Association's flagship, peer-reviewed journal Circulation and simultaneously in the Journal of the American College of Cardiology.

14 May 2024

Study links higher-potency cannabis use in youth to increased risk of psychotic experiences

Young individuals consuming higher-potency cannabis, such as skunk, between ages 16 and 18, are twice as likely to have psychotic experiences from age 19 to 24 compared to those using lower-potency cannabis.

14 May 2024

Medical Condition News

New study identifies 17 genes driving clonal hematopoiesis in aging blood cells

More than 20,000 volunteers join effort to accelerate dementia drug development

Oncotype DX Breast Recurrence Score test recommended by NICE for lymph node-positive breast cancer patients

Metabolomics study finds biomarkers predicting autism in newborns

Sleep and anesthesia hinder brain toxin clearance, study reveals

Semaglutide shows significant weight loss and health benefits in four-year obesity study

Paddling through mental health: Long-term benefits of SUP revealed in "Freedom on Water" study

St. Jude researchers unveil mechanisms to block PXR and enhance drug potency

Innovative 'mini-brains' could revolutionize Alzheimer's diagnosis and treatment

New technique reveals brain cells age at different rates

Study proposes a novel therapeutic avenue for tackling EHF-induced cholangiocarcinogenesis

Researchers find beneficial effects of a novel drug in the management of myocardial infarction

Pharmacological treatment reduces specific crimes in adolescents with ADHD

New risk assessment tool developed for predicting outcomes in heart failure patients

Human cell-based model of thoracic aortic aneurysm offers new opportunities for drug development

Racial and ethnic disparities in Alzheimer's diagnosis and CNS drug prescription

Experts advocate for terminology change in brain injury research

Investigational drug shows promise in increasing oxygen uptake for patients with heart condition

New joint guideline highlights importance of coordinated care for peripheral artery disease

Study links higher-potency cannabis use in youth to increased risk of psychotic experiences

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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