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Y chromosome loss linked to poor cancer outcomes

When cancer cells in male patients and immune cells in their tumors both lose the Y chromosome, those patients tend to experience poorer outcomes than patients without Y chromosome loss, according to new findings from Cedars-Sinai investigators.

4 Jun 2025

Study highlights the lasting toll of colorectal cancer on women's sexual health

A new University of British Columbia-led study is shedding light on a long-overlooked consequence of colorectal cancer: the lasting toll it can take on women's sexual health, even years after treatment ends.

4 Jun 2025

New screening tool enhances early detection of pulmonary hypertension

A novel screening approach developed by physicians at the Lewis Katz School of Medicine at Temple University shows significant promise for improving the detection of pulmonary arterial hypertension (PAH)-a life-threatening form of heart failure related to high blood pressure in the lung circulation that is often overlooked due to vague symptoms such as fatigue and shortness of breath.

4 Jun 2025

American Heart Association fellowship supports study of protein linking obesity and heart disease

At home in Australia, Mark Renton started playing football as soon as he could. He figured it would eventually lead to a career prescribing strength training and exercise regimens to athletes.

4 Jun 2025

New molecular mechanism offers hope for causal epilepsy treatments

Epilepsy is primarily treated symptomatically - that is, the majority of the available medications aim to suppress seizures without influencing the underlying causes of the disease.

4 Jun 2025

Study explores the connection between abnormal uterine bleeding and hyperinsulinemia

Insulin resistance is becoming more common because of a combination of lifestyle factors, genetics, and medical conditions. A lot of those same risk factors play a role in abnormal uterine bleeding.

4 Jun 2025

AI and human scientists collaborate to discover new cancer drug combinations

An 'AI scientist', working in collaboration with human scientists, has found that combinations of cheap and safe drugs – used to treat conditions such as high cholesterol and alcohol dependence – could also be effective at treating cancer, a promising new approach to drug discovery.

4 Jun 2025

Two blood pressure management strategies yield similar cognitive outcomes after non-cardiac surgery

A large international study has found that two different approaches to managing blood pressure in older adults undergoing non-cardiac surgery, one avoiding low blood pressure (hypotension) and the other high blood pressure (hypertension), lead to similar outcomes in terms of in-hospital delirium and cognitive changes one year after surgery.

4 Jun 2025

Variability in blood sugar response depends on individual's metabolic health status

A study led by researchers at Stanford Medicine shows that differences in blood sugar responses to certain carbohydrates depend on details of an individual's metabolic health status.

4 Jun 2025

New marker identifies the functional maturity and heterogeneity of stem cell–derived islet organoids

Over 500 million people worldwide suffer from diabetes-a disease that contributes to major complications such as stroke, kidney failure, cancer, and Alzheimer's disease.

4 Jun 2025

Key proteins and pathways drive the success of CAR-T cell therapy

A study conducted by researchers at the Center for Cell-Based Therapy (CTC) highlights key proteins and signaling pathways involved in the efficacy of immunotherapy based on CAR-T cells (lymphocytes modified in the laboratory to fight cancer).

4 Jun 2025

PCSK9 protein controls how pancreatic cancer cells spread to the lung or liver

A protein called PCSK9 determines how pancreatic cancer cells metastasize to different parts of the body.

4 Jun 2025

Two patients faced chemo. The one who survived demanded a test to see if it was safe.

JoEllen Zembruski-Ruple, while in the care of New York City's renowned Memorial Sloan Kettering Cancer Center, swallowed the first three chemotherapy pills to treat her squamous cell carcinoma on Jan. 29, her family members said. They didn't realize the drug could kill her.

4 Jun 2025

SWOG S2302 Pragmatica-Lung study demonstrates value of streamlined clinical trials in real world settings

The SWOG S2302 Pragmatica-Lung trial, which broke new ground with its streamlined pragmatic design, unusually broad eligibility criteria, and reduced data collection, has quickly answered its primary question, finding that the investigational combination it tested did not significantly extend overall survival compared to standard of care treatments.

4 Jun 2025

Does lithium offer hope for long COVID brain fog and fatigue? New trial gives mixed results

A randomized clinical trial found that low-dose lithium aspartate did not improve cognitive dysfunction or fatigue in long COVID patients. Higher doses showed possible benefits in a small exploratory substudy, but larger trials are needed.

4 Jun 2025

ADHD linked to higher risk of irritable bowel syndrome, global study reveals

A global meta-analysis found that people with ADHD are significantly more likely to have irritable bowel syndrome (IBS), while the overall risk for other intestinal disorders is not increased. The findings highlight the importance of gut-brain interactions in ADHD and call for further research on microbiome-based therapies.

3 Jun 2025

AI spots future breast cancer risk in mammograms years before diagnosis

In a large Norwegian study, a commercial AI tool analyzed routine mammograms and identified women at elevated risk of developing breast cancer up to 4–6 years before diagnosis. These AI-generated risk scores may help personalize breast cancer screening and facilitate earlier interventions.

3 Jun 2025

Navigating the dual role of B cells in tumor immunity

B lymphocytes exhibit dual roles in tumorigenesis, acting as both allies and adversaries in the tumor microenvironment (TME).

3 Jun 2025

Early camizestrant therapy keeps advanced breast cancer in check

Switching to camizestrant, a next-generation oral SERD, significantly prolongs progression-free survival and maintains quality of life in patients with ESR1-mutated, hormone receptor-positive advanced breast cancer. The proactive, biomarker-guided approach allows earlier intervention and may redefine standard care.

3 Jun 2025

Whole-class mental health sessions in schools help reduce depression and anxiety

Whole-class mental health sessions in schools have a small but significant effect in reducing depression and anxiety symptoms, according to new analysis led by researchers at UCL (University College London) and Anna Freud.

3 Jun 2025

Medical Condition News

Y chromosome loss linked to poor cancer outcomes

Study highlights the lasting toll of colorectal cancer on women's sexual health

New screening tool enhances early detection of pulmonary hypertension

American Heart Association fellowship supports study of protein linking obesity and heart disease

New molecular mechanism offers hope for causal epilepsy treatments

Study explores the connection between abnormal uterine bleeding and hyperinsulinemia

AI and human scientists collaborate to discover new cancer drug combinations

Two blood pressure management strategies yield similar cognitive outcomes after non-cardiac surgery

Variability in blood sugar response depends on individual's metabolic health status

New marker identifies the functional maturity and heterogeneity of stem cell–derived islet organoids

Key proteins and pathways drive the success of CAR-T cell therapy

PCSK9 protein controls how pancreatic cancer cells spread to the lung or liver

Two patients faced chemo. The one who survived demanded a test to see if it was safe.

SWOG S2302 Pragmatica-Lung study demonstrates value of streamlined clinical trials in real world settings

Does lithium offer hope for long COVID brain fog and fatigue? New trial gives mixed results

ADHD linked to higher risk of irritable bowel syndrome, global study reveals

AI spots future breast cancer risk in mammograms years before diagnosis

Navigating the dual role of B cells in tumor immunity

Early camizestrant therapy keeps advanced breast cancer in check

Whole-class mental health sessions in schools help reduce depression and anxiety

Exploring the nanoscale: How AFM is transforming cosmetic science

Innovating Texture and Culture in Plant-Based Foods

Advancing brain microphysiological systems (bMPS)

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