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MicroRNAs in breast cancer play a role in development of resistance to tamoxifen

Many breast cancer patients are treated with a drug called tamoxifen. The substance blocks the effect of estrogen and thus suppresses the growth signals of this hormone in cancer cells. When resistance to the drug develops, tumor cells change their growth program: They change their behavior and shape, become more mobile and also adopt the ability to invade surrounding tissue. Scientists working with PD (Associate Professor) Dr. Stefan Wiemann of the German Cancer Research Center (DKFZ) have now also observed these changes in tamoxifen resistant breast cancer cells.

5 May 2012

Low levels of testosterone in men could increase risk of diabetes

Low levels of testosterone in men could increase their risk of developing diabetes, a study suggests.

5 May 2012

Pfizer terminates Lyrica Phase 3 trial on neuropathic pain associated with HIV neuropathy

Pfizer Inc. announced today that it has stopped a Phase 3 clinical trial of Lyrica (pregabalin) in patients with neuropathic pain associated with HIV neuropathy, a form of nerve damage characterized by burning pain usually beginning in the feet. The decision follows review of a planned interim analysis of the study by the trial's external Data Monitoring Committee.

5 May 2012

New research about why people forego colorectal cancer screening

New research about why people forego colorectal cancer (CRC) screening suggests that three fears play a significant role; fear of embarrassment, fear of getting AIDS and fear of pain may make some seniors skip the potentially lifesaving tests.

5 May 2012

Load-bearing sports may protect young men from osteoporosis

Young men who play volleyball, basketball or other load-bearing sports for four hours a week or more increase bone mass and might gain protection from developing osteoporosis later in life, according to a new study in the May issue of the Journal of Bone and Mineral Research.

5 May 2012

Isis commences ISIS-APOCIIIRx Phase 2 study in hypertriglyceridemia

Isis Pharmaceuticals, Inc. announced the initiation of a Phase 2 study evaluating ISIS-APOCIIIRx in patients with hypertriglyceridemia.

5 May 2012

Research roundup: Chronic disease interventions could save states money; Drilling into childhood cancer disparities; National heart emergency care system proposed

Urban Institute: Potential Savings Through Prevention Of Avoidable Chronic Illness Among CalPERS State Active Members -- California is one of many states in financial crisis, and according to this report, it could save millions of dollars on state employee health benefits by preventing chronic disease.

5 May 2012

Pfizer’s Lyrica Phase 3 study on pDPN fails to meet primary endpoint

Pfizer Inc. announced today that a Phase 3 randomized withdrawal design study for Lyrica (pregabalin) in patients with inadequately treated painful diabetic peripheral neuropathy (pDPN) did not meet its primary efficacy endpoint, change in endpoint mean pain score relative to baseline.

5 May 2012

Guidelines on cardiovascular disease prevention in clinical practice launched at EuroPRevent2012

The latest cardiovascular disease (CVD) prevention guidelines have been overhauled to produce a user friendly document with concise messages that awards greater weight than ever before to evidence from clinical trials and observational population studies. The "European Guidelines on Cardiovascular Disease Prevention in Clinical Practice (version 2012)" - were launched at the EuroPRevent2012 meeting in Dublin, Ireland.

4 May 2012

Patterns of brain activity that play a role in recall of memories and decision-making

UCSF scientists have identified patterns of brain activity in the rat brain that play a role in the formation and recall of memories and decision-making. The discovery, which builds on the team's previous findings, offers a path for studying learning, decision-making and post-traumatic stress syndrome.

4 May 2012

Improved lung-cancer screening by combining blood test with CT imaging

National Jewish Health is seeking to refine and improve lung-cancer screening by combining a blood test with CT imaging to detect disease earlier and more effectively. The trial combines a CT chest scan and the EarlyCDT-Lung blood test to screen for cancer, and seeks to build on recent research demonstrating that CT screening alone can reduce lung-cancer mortality.

4 May 2012

Growing role of body image drugs

In the current issue of Psychotherapy and Psychosomatics Kanayama et al. analyse the growing role of body image drugs.

4 May 2012

Malfunctioning single proteins cause disruptions in neuronal junctions leading to autism

Malfunctioning single proteins can cause disruptions in neuronal junctions leading to autistic forms of behavior. A current study, published in the scientific journal Nature, comes to this conclusion after examining genetically altered mice.

4 May 2012

Study affirms necessity of heart rehabilitation programs for cardiac patients

University of Granada researchers affirm that it is "essential" that heart rehabilitation programs aimed at patients with any heart disease are established and provided to cardiac patients. The study included a sample of 200 patients suffering from heart disease.

4 May 2012

Energy/Sports drinks damage teeth enamel raising risk of cavities: Study

Researcher Poonam Jain, associate professor and director of community dentistry at the Southern Illinois University School of Dental Medicine said, “The big misconception is that energy drinks and sports drinks are healthier than soda for oral health. This study completely disproves that, because they erode or thin out the enamel of the teeth, leaving them more susceptible to decay and sensitivity.”

4 May 2012

Aspirin versus warfarin for heart failure patients

In a new study on more than 2,000 patients, published in the New England Journal of Medicine, researchers found that aspirin was as effective as the commonly prescribed drug warfarin. It said each drug had risks, but they had similar benefits overall.

4 May 2012

SPECT/CT can change clinical management of thyroid cancer

The use of single positron emission computed tomography (SPECT)/computed tomography (CT) has been reported to change clinical management in a significant number of thyroid cancer patients according to research presented in the May issue of The Journal of Nuclear Medicine.

4 May 2012

Researchers identify new functions of cohesin SA1 that are relevant for cancer and CdLS

Cohesin is a ring-shaped protein complex involved in the spatial organization of the genome and in mitotic chromosome structure. Vertebrate somatic cells have two versions of cohesin that contain either SA1 or SA2, but their functional specificity has been largely ignored. Researchers of the Spanish National Cancer Research Centre (CNIO) under the direction of Ana Losada have identified new functions of cohesin SA1 that are relevant for two human diseases, cancer and Cornelia de Lange Syndrome.

4 May 2012

CSL Behring commences C1-INH phase I/II study in hereditary angioedema

CSL Behring announced today that it has initiated an international phase I/II study of a volume-reduced, subcutaneous formulation of C1-esterase inhibitor (C1-INH) concentrate in patients with hereditary angioedema.

4 May 2012

Hispanics more likely to develop precancerous colorectal polyps

Blacks and Hispanics have a significantly higher risk of developing precancerous colorectal polyps compared with whites, according to a study by researchers at NewYork - Presbyterian Hospital/Columbia University Medical Center.

4 May 2012

Medical Condition News

MicroRNAs in breast cancer play a role in development of resistance to tamoxifen

Low levels of testosterone in men could increase risk of diabetes

Pfizer terminates Lyrica Phase 3 trial on neuropathic pain associated with HIV neuropathy

New research about why people forego colorectal cancer screening

Load-bearing sports may protect young men from osteoporosis

Isis commences ISIS-APOCIIIRx Phase 2 study in hypertriglyceridemia

Research roundup: Chronic disease interventions could save states money; Drilling into childhood cancer disparities; National heart emergency care system proposed

Pfizer’s Lyrica Phase 3 study on pDPN fails to meet primary endpoint

Guidelines on cardiovascular disease prevention in clinical practice launched at EuroPRevent2012

Patterns of brain activity that play a role in recall of memories and decision-making

Improved lung-cancer screening by combining blood test with CT imaging

Growing role of body image drugs

Malfunctioning single proteins cause disruptions in neuronal junctions leading to autism

Study affirms necessity of heart rehabilitation programs for cardiac patients

Energy/Sports drinks damage teeth enamel raising risk of cavities: Study

Aspirin versus warfarin for heart failure patients

SPECT/CT can change clinical management of thyroid cancer

Researchers identify new functions of cohesin SA1 that are relevant for cancer and CdLS

CSL Behring commences C1-INH phase I/II study in hereditary angioedema

Hispanics more likely to develop precancerous colorectal polyps

The evolution of OCT for retinal imaging and disease intervention

Supercharging Next-Gen Antibody Discovery with AI and High-Throughput Experimentation

Prof. Dr. Kristina Kusche-Vihrog

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