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Alzheimer's may spread through connected neurons

Alzheimer's disease and other forms of dementia may spread within nerve networks in the brain by moving directly between connected neurons, instead of in other ways proposed by scientists, such as by propagating in all directions, according to researchers who report the finding in the March 22 edition of the journal Neuron.

22 Mar 2012

Researchers explain how obscurins suppress breast cancer formation

A new discovery published online in The FASEB Journal may lead to a new tool to help physicians assess breast cancer risk as well as diagnose the disease. In the report, researchers from Johns Hopkins University and the University of Maryland, explain how proteins, called "obscurins," once believed to only be in muscle cells, act as "tumor suppressor genes" in the breast.

22 Mar 2012

Scientists create worm model of back-up telomere repair strategy

Rapidly dividing cancer cells are skilled at patching up damage that would stop normal cells in their tracks, including wear and tear of telomeres, the protective caps at the end of each chromosome.

22 Mar 2012

Thromboembolic events can occur after musculoskeletal injury and related surgery

Below is a news summary of an orthopaedic research study appearing in the March 21, 2012 issue of the Journal of Bone and Joint Surgery (JBJS), as well as the issues' full Table of Contents.

22 Mar 2012

International study into safety of NSAIDs reaches enrollment milestone

An international study into the safety of some of the most widely used medicines has reached a significant milestone by recruiting its 6,000th patient.

22 Mar 2012

Urban children more likely to be smokers

More than 75 percent of fourth-graders in urban and rural settings have measurable levels of a nicotine breakdown product in their saliva that documents their second-hand smoke exposure, researchers report.

22 Mar 2012

New method for in vivo study of unknown selenium metabolism

Spanish and Danish researchers have developed a method for the in vivo study of the unknown metabolism of selenium, an essential element for living beings. The technique can help clarify whether or not it possesses the anti-tumour properties that have been attributed to it and yet have not been verified through clinical trials.

22 Mar 2012

$Large geographic variation in risk of hip fracture$

Large geographic variation in risk of hip fracture

An extensive study of country-specific risk of hip fracture and 10-year probability of a major fragility fracture has revealed a remarkably large geographic variation in fracture risk. Even accounting for possible errors or limitations in the source data, there was an astonishing 10-fold variation in hip fracture risk and fracture probability between countries.

22 Mar 2012

EMS responders can play a significant role in reducing MCTB time for STEMI patients

Health care practitioners have long understood the importance of "door to balloon" time for heart attack patients-the faster they can get the patient from the door of the hospital to a catheterization lab to open a clogged artery, the better the patient will do.

22 Mar 2012

Pannexins may contribute to symptoms related to IBD

Researchers from the Hotchkiss Brain Institute (HBI) and the Snyder Institute for Chronic Diseases at the University of Calgary's Faculty of Medicine have discovered a pathway that may contribute to the symptoms related to Crohn's disease and ulcerative colitis, collectively known as Inflammatory Bowel Disease.

22 Mar 2012

Scientists reveal first-ever glimpse of complete kappa opioid receptor structure

At the molecular level, drugs like salvinorin A (the active ingredient of the hallucinogenic plant Salvia divinorum) work by activating specific proteins, known as receptors, in the brain and body.

22 Mar 2012

WHO convenes lawmakers from Southeast Asia to discuss bolstering of health systems in region

This week the WHO brought together lawmakers from across Southeast Asia in Bangkok "to discuss how to bolster their health systems back home," IRIN reports. Meeting participants were "called on to advocate the boosting of health spending, workforces and access to health care in their home countries in addition to drafting 'healthy public policies,' such as conducting health assessments before large infrastructural projects are undertaken," the news service writes.

22 Mar 2012

Hospitalized older people may have increased risk of memory problems

A new study suggests that older people may have an increased risk of problems with memory and thinking abilities after being in the hospital, according to research published in the March 21, 2012, online issue of Neurology, the medical journal of the American Academy of Neurology.

22 Mar 2012

Anxiety, depression and social support can predict early alcohol and illicit drug use in youth

Anxiety, depression, stress and social support can predict early alcohol and illicit drug use in youth, according to a study from Carolyn McCarty, PhD, of Seattle Children's Research Institute, and researchers from the University of Washington and Seattle University.

22 Mar 2012

Two Brandeis researchers receive Canada Gairdner Award

Two distinguished Brandeis researchers, whose long-standing collaboration led to pioneering discoveries about the workings of the biological clock and its role in circadian rhythms, today were awarded the prestigious Canada Gairdner Award, that nation's foremost international scientific honor.

22 Mar 2012

BHR Pharma enrolls first 400 patients for BHR-100 pivotal trial for TBI

As communities in the United States gather in support of Traumatic Brain Injury (TBI) Awareness Day, BHR Pharma, LLC's SyNAPSe- clinical trial reaches an important enrollment milestone.

22 Mar 2012

Peripheral nerve stimulation may help manage neuropathic pain in injured soldiers

An peripheral nerve stimulation technique may be a valuable new approach for relief of severe neuropathic (nerve-related) pain in injured soldiers, reports an article in the March issue of Anesthesia & Analgesia, official journal of the International Anesthesia Research Society.

22 Mar 2012