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Pyruvate kinase M2 fuels tumor growth by influencing H3 histone protein

A metabolic protein that nourishes cancer cells also activates tumor-promoting genes by loosening part of the packaging that entwines DNA to make up chromosomes, a team led by scientists at The University of Texas MD Anderson Cancer Center reports in the Aug. 16 issue of Cell.

17 Aug 2012

Mepolizumab almost halves exacerbations in severe asthma patients

The largest study of patients with severe asthma to date, published in The Lancet special issue on respiratory medicine, shows that those treated with the monoclonal antibody mepolizumab experienced an almost 50% reduction in severe exacerbations, emergency room visits, and hospitalisations compared with patients given placebo.

17 Aug 2012

Retail medical clinic visits increase four-fold from 2007-2009

Fast-growing retail medical clinics are attracting more older patients and delivering more preventive care, particularly flu shots and other vaccinations, according to a new study from the RAND Corporation.

17 Aug 2012

Dendritic cells protect against MS in mouse model

In multiple sclerosis, the immune system attacks nerves in the brain and spinal cord, causing movement problems, muscle weakness and loss of vision. Immune cells called dendritic cells, which were previously thought to contribute to the onset and development of multiple sclerosis, actually protect against the disease in a mouse model, according to a study published by Cell Press in the August issue of the journal Immunity.

17 Aug 2012

Study provides insights into life-time risk of end-stage renal disease

How likely are middle-aged adults to develop kidney failure during their lifetime? A study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN) provides some insights, which may be used to help set priorities related to kidney care and to increase public interest in the prevention of kidney disease.

17 Aug 2012

Peptide combinations might offer more effective cancer therapy

Two studies suggest that two peptide agents used either together or individually with a low-dose of a standard chemotherapy drug might offer more effective cancer therapy than current standard single-drug treatments.

17 Aug 2012

New DNA sequencing tests improve ability to analyze genetic disorders

Scientists at the University of Medicine and Dentistry of New Jersey-New Jersey Medical School (UMDNJ-NJMS) have developed new DNA sequencing tests that hold significant promise for decreasing costs associated with diagnosing cancer and hereditary diseases, including cysticfibrosis.

17 Aug 2012

U-M, IGC launch new joint venture for personalized medicine

As a key step toward providing patients with treatments based on their own DNA profiles, the University of Michigan and the International Genomics Consortium (IGC) have launched a new joint venture that will help usher in an age of personalized medicine.

17 Aug 2012

Vancomycin may not always be the best choice for treatment of bloodstream infections

The antibiotic most commonly prescribed to treat bloodstream infections in dialysis patients may not always be the best choice, according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN).

17 Aug 2012

Third universal definition of myocardial infarction to be presented at ESC Congress 2012

A new definition of heart attack will be presented at the ESC Congress 2012. The third universal definition of myocardial infarction (MI) clarifies the controversial area of procedural related MI and will be the gold standard for diagnosis and clinical trial endpoints.

17 Aug 2012

Nostrum, VCU sign license agreement to develop inhaled dapsone for respiratory diseases

Virginia Commonwealth University and Nostrum Pharmaceuticals, LLC, are pleased to announce the signing of a license agreement for the development of inhaled dapsone for the treatment of respiratory diseases.

17 Aug 2012

Research examines racial and ethnic differences in strokes

Blacks who survived a stroke caused by bleeding in the brain had higher blood pressure than whites a year later, according to a study published today in the journal Stroke. The finding might help explain why blacks have a greater risk of suffering a second stroke than whites.

17 Aug 2012

Johns Hopkins undergraduates invent disposable suturing tool

After a surgeon stitches up a patient's abdomen, costly complications -- some life-threatening -- can occur. To cut down on these postoperative problems, Johns Hopkins undergraduates have invented a disposable suturing tool to guide the placement of stitches and guard against the accidental puncture of internal organs.

17 Aug 2012