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Emergent commences Phase 2 combination trial of TRUw-016 with bendamustine in relapsed CLL

Emergent BioSolutions Inc. today announced the initiation of a Phase 2 study (protocol 16201) of TRU-016 in combination with bendamustine for patients with relapsed chronic lymphocytic leukemia (CLL).

29 Dec 2011

Troponin I level test may help rule-out diagnosis of heart attack

For patients admitted to an emergency department with chest pain, use of a contemporary or highly sensitive test for levels of troponin I (a protein in muscle tissue) may help rule-out a diagnosis of heart attack, while changes in the measured levels of this biomarker at 3 hours after admission may be useful to confirm a diagnosis of heart attack, according to a study in the December 28 issue of JAMA.

28 Dec 2011

Research provides first proof of epigenetic risk factor for type 2 diabetes

Research carried out at the Hebrew University of Jerusalem has provided the first proof of molecular risk factors leading to type 2 diabetes, providing an "early warning" sign that could lead to new approaches to treating this and other human disease conditions.

28 Dec 2011

Vejthani Hospital Bangkok offers High Tibial Osteotomy Surgery for osteoarthritis

Vejthani Hospital Bangkok offers a High Tibial Osteotomy Surgery for osteoarthritis at TJR Center. The procedure prolongs the life of a damaged knee, helps relieve pain in the knee and delays the need for a total knee replacement.

28 Dec 2011

Scientists identify molecular player critical to proper working of important health proteins

Half the drugs used today target a single class of proteins - and now scientists have identified an important molecular player critical to the proper workings of those proteins critical to our health.

28 Dec 2011

Meta-analysis does not find significant association between CYP2C19 genotype and cardiovascular events

Although the U.S. Food and Drug Administration (FDA) has recommended that a certain type of genetic testing (for the genotype CYP2C19) be considered before prescribing the drug clopidogrel to identify individuals who may be less responsive to the medication, a review and analysis of previous studies did not find an overall significant association between the CYP2C19 genotype and cardiovascular events.

28 Dec 2011

Obesity associated with hypothalamic injury

The number of people who suffer from one or more of the adverse complications of obesity, including type 2 diabetes and heart disease is rapidly increasing. Thus far, drugs designed to treat obesity have shown limited efficacy and have been associated with serious side effects.

28 Dec 2011

DNA stays too tightly wound in brain cells of patients with schizophrenia

Scientists at The Scripps Research Institute have discovered that DNA stays too tightly wound in certain brain cells of schizophrenic subjects. The findings suggest that drugs already in development for other diseases might eventually offer hope as a treatment for schizophrenia and related conditions in the elderly.

28 Dec 2011

Celiac disease may increase risk of disordered eating, depression in women

Women with celiac disease -- an autoimmune disorder associated with a negative reaction to eating gluten -- are more likely than the general population to report symptoms of depression and disordered eating, even when they adhere to a gluten-free diet, according to researchers at Penn State, Syracuse University and Drexel University.

28 Dec 2011

IL-1 gene inactivation may reduce severe clinical complications of atherosclerosis

Atherosclerosis is a disease of the major arterial blood vessels. It is one of the major causes of heart attack and stroke. The proinflammatory molecule IL-1 has been linked to atherosclerosis and a clinical trial has been launched in which an antibody specific for IL-1-beta is being studied for its effects on the severe clinical complications of atherosclerosis.

28 Dec 2011

Working patterns should now be considered a specific risk factor for obesity, type 2 diabetes

The poor diet of shift workers should be considered a new occupational health hazard, according to an editorial published in this month's PLoS Medicine.

28 Dec 2011

Mylan receives final FDA approval for Levetiracetam ER Tablets ANDA

Mylan Inc. today announced that its subsidiary Mylan Pharmaceuticals Inc. has received final approval from the U.S. Food and Drug Administration (FDA) for its Abbreviated New Drug Application (ANDA) for Levetiracetam Extended-release (ER) Tablets, 500 mg and 750 mg.

28 Dec 2011

Researchers decode and characterize DNA repair mechanism

Oxidative stress is the cause of many serious diseases such as cancer, Alzheimer's, arteriosclerosis and diabetes. It occurs when the body is exposed to excessive amounts of electrically charged, aggressive oxygen compounds. These are normally produced during breathing and other metabolic processes, but also in the case of ongoing stress, exposure to UV light or X-rays. If the oxidative stress is too high, it overwhelms the body's natural defences. The aggressive oxygen compounds destroy genetic material, resulting in what are referred to as harmful 8-oxo-guanine base mutations in the DNA.

28 Dec 2011

Current scientific understanding of left and right-handedness

Left-handedness is sometimes the expression of a genetic defect or an early developmental disturbance. In this issue of Deutsches Ärzteblatt International, Stefan Gutwinski and coauthors present the current scientific understanding of left- and right-handedness.

28 Dec 2011

New approach may prevent septic shock

Researchers of VIB and UGent have discovered a new approach to preventing septic shock, an often fatal extreme inflammatory reaction of the body. It is the most frequent cause of death at intensive care departments in hospitals.

28 Dec 2011

Epilepsy may not increase risk of committing violent crime

Despite current public and expert opinion to the contrary, having the neurological condition epilepsy is not directly associated with an increased risk of committing violent crime.

28 Dec 2011

Oral and tactile sensitivities in childhood can lead to OCD

In childhood, rituals like regular schedules for meal, bath, and bed times are a healthy part of behavioral development. But combined with oral and tactile sensitivities, such as discomfort at the dentist or irritation caused by specific fabrics, these rituals could be an early warning sign of adult Obsessive Compulsive Disorder.

27 Dec 2011

Perrigo receives final approval from FDA for Desloratadine ANDA

Perrigo Company today announced that it has received final approval from the U.S. Food and Drug Administration for its abbreviated new drug application (ANDA) for Desloratadine tablets.

27 Dec 2011

Tbx3 dysfunction may cause acquired and spontaneous arrhythmias

In a study published in the Dec. 26, 2011, Proceedings of the National Academy of Sciences early edition, researchers led by the University of Utah showed the CCS is extremely sensitive to levels of Tbx3. Mouse embryos with Tbx3 levels below a critical threshold suffered arrhythmia and couldn't survive. As the levels of Tbx3 were increased, mice survived to birth, but as adults they developed arrhythmias or had sudden death.

27 Dec 2011

CEL-SCI to expand Multikine Phase III trial in head and neck cancer

CEL-SCI Corporation is in the process of expanding its Phase III clinical trial of the investigational therapy Multikine (Leukocyte Interleukin, Injection) to 4 additional European countries - Spain, Czech Republic, Slovakia and Croatia.

27 Dec 2011