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Acceleron, Celgene enter development collaboration for ACE-536 protein therapeutic to treat anemia

Acceleron Pharma, Inc., a biopharmaceutical company developing protein therapeutics for cancer and orphan diseases, and Celgene Corporation today announced that the companies have entered into a joint development and commercialization agreement for ACE-536 for the treatment of anemia.

3 Aug 2011

Residents displaced during civil conflicts at higher risk of depression, anxiety and PTSD

Residents of Sri Lanka who were internally displaced during the civil conflict that occurred in their country from 1983 to 2009 have a higher prevalence of war-related mental health conditions that include depression, anxiety and posttraumatic stress disorder, according to a study in the August 3 issue of JAMA, a theme issue on violence and human rights.

3 Aug 2011

Incyte announces FDA acceptance of NDA filing for ruxolitinib to treat myelofibrosis

Incyte Corporation announced today that the US Food and Drug Administration (FDA) has accepted for filing the New Drug Application (NDA) for Incyte's lead investigational compound, ruxolitinib, as a potential treatment for patients with myelofibrosis.

3 Aug 2011

Researchers discover biological mechanism behind sarcopenia

Researchers at Columbia University Medical Center have discovered the biological mechanism behind age-related loss of muscle strength and identified a drug that may help reverse this process.

3 Aug 2011

Gender-based violence may increase lifetime prevalence of mental disorders in women

Women who reported experiencing gender-based violence, such as rape, sexual assault, intimate partner violence and stalking, had an associated higher lifetime prevalence of mental health disorders, dysfunction and disability, according to a study in the August 3 issue of JAMA, a theme issue on violence and human rights.

3 Aug 2011

Narrative exposure therapy can reduce PTSD symptoms in former child soldiers

Former child soldiers from Northern Uganda who received a short-term trauma-focused intervention had a greater reduction of symptoms of posttraumatic stress disorder than soldiers who received other therapy, according to a study in the August 3 issue of JAMA, a theme issue on violence and human rights.

3 Aug 2011

$Strengths and limitations of FRAX in assessing fracture risk$

Strengths and limitations of FRAX in assessing fracture risk

FRAX- is a computer-based algorithm developed by the World Health Organization Collaborating Centre for Metabolic Bone Diseases to help predict the 10-year risk of fragility fracture. Now with 34 specific country models, FRAX is being used increasingly by physicians around the world to help assess their patients' fracture risk in the course of a clinical assessment.

3 Aug 2011

New method of delivering growth factors could lead to revolutionary heart treatment

Ever since the Nobel Prize for nerve growth factor was awarded more than 30 years ago, researchers have been searching for ways to use growth factor clinically.

3 Aug 2011

Chromogenic in situ hybridization can identify ALK rearrangement in lung cancer patients

A relatively simple and inexpensive method may be used to determine whether a lung cancer patient is a candidate for crizotinib therapy, according to research published in the August issue of the Journal of Thoracic Oncology, the official monthly journal of the International Association for the Study of Lung Cancer.

3 Aug 2011

Study: Subjective memory deterioration could be the first manifestation of Alzheimer's

Scientists at Charité - Universitätsmedizin Berlin, Universitätsklinikum Bonn, and Deutsches Zentrum für Neurodegenerative Erkrankungen in Bonn succeeded for the first time in demonstrating that even in merely subjective cases of memory deterioration changes may be visible in certain brain structures.

3 Aug 2011

New approach to overcome complexities of developing more effective drugs for treating diseases

Pharmaceutical scientists typically face a meager five percent success rate for anti-cancer drugs in clinical trials. To help improve this success rate, Japanese scientists, led by Dr. Tetsuya Terasaki, one of the top pharmaceutical scientists focused on drug transporters, have developed a new approach designed to overcome complexities of developing new, more effective drugs to treat diseases, including cancer.

3 Aug 2011

Combination molecules with BRAF inhibitors may help overcome drug resistance in melanoma patients

About 50 to 60 percent of patients with melanoma have a mutation in the BRAF gene that drives the growth of their cancer. Most of these patients respond well to two novel agents being studied in clinical trials that inhibit the gene, with remarkable responses that are, unfortunately, almost always limited in duration.

3 Aug 2011

EAST clinical trial to assess early comprehensive rhythm control therapy for AF

The first patient has been enrolled, in Hamburg, Germany, for the largest pan-European study to determine whether an early comprehensive rhythm control strategy for the treatment of atrial fibrillation (AF) will benefit patients.

3 Aug 2011

Role of molecular imaging in diagnosis and clinical trials

Two new studies published in the August issue of The Journal of Nuclear Medicine (JNM) provide insight into the potential of positron emission tomography (PET) to differentiate between types of dementia and to identify pharmaceuticals to slow the progress of dementia. With proposed National Institute on Aging (NIA) and the Alzheimer's Association guidelines for detecting Alzheimer's-related brain changes expected in September, these articles give a preview of what may be to come.

3 Aug 2011

Insight into how brain organizes during development

Scientists at the Allen Institute for Brain Science have taken an important step in identifying how the brain organizes itself during development. The findings, published in the Journal of Comparative Neurology today, describe - in more detail than ever before - the consequences of the loss of a key molecule involved in establishing proper brain architecture during brain development.

3 Aug 2011

Posttraumatic stress disorder linked to persistent fears of recurrent SAH

One-third of patients who have survived a life-threatening subarachnoid hemorrhage (SAH) have disabling symptoms of posttraumatic stress disorder (PTSD), reports a study in the August issue of Neurosurgery, official journal of the Congress of Neurological Surgeons. The journal is published by Lippincott Williams & Wilkins, a part of Wolters Kluwer Health.

3 Aug 2011

Alcohol, tobacco use increase risk of upper aero-digestive tract cancers

Upper aero-digestive tract cancers (UADT), especially those of the oral cavity, pharynx, and larynx, are often referred to as alcohol-related cancers as it has been shown repeatedly that heavy drinkers, in particular, are at increased risk.

3 Aug 2011

Mood-related brain protein linked to sadness during cigarette withdrawal

Heavy smokers may experience sadness after quitting because early withdrawal leads to an increase in the mood-related brain protein monoamine oxidase A (MAO-A), a new study by the Centre for Addiction and Mental Health (CAMH) has shown. This finding, which was published in the Archives of General Psychiatry, may also explain why heavy smokers are at high risk for clinical depression.

3 Aug 2011

Double-lung transplant survivor stays busy since retirement

Fewer than half of lung transplant patients survive for five years. But nearly 14 years after receiving a double-lung transplant at Loyola University Medical Center, Damian Neuberger's lungs continue to function normally. He breathes easily while walking four or five miles a day.

3 Aug 2011

Combination of six common QA measures could prevent radiotherapy errors

A combination of several well-known safety procedures could greatly reduce patient-harming errors in the use of radiation to treat cancer, according to a new study led by Johns Hopkins researchers.

3 Aug 2011

Medical Condition News

Acceleron, Celgene enter development collaboration for ACE-536 protein therapeutic to treat anemia

Residents displaced during civil conflicts at higher risk of depression, anxiety and PTSD

Incyte announces FDA acceptance of NDA filing for ruxolitinib to treat myelofibrosis

Researchers discover biological mechanism behind sarcopenia

Gender-based violence may increase lifetime prevalence of mental disorders in women

Narrative exposure therapy can reduce PTSD symptoms in former child soldiers

Strengths and limitations of FRAX in assessing fracture risk

New method of delivering growth factors could lead to revolutionary heart treatment

Chromogenic in situ hybridization can identify ALK rearrangement in lung cancer patients

Study: Subjective memory deterioration could be the first manifestation of Alzheimer's

New approach to overcome complexities of developing more effective drugs for treating diseases

Combination molecules with BRAF inhibitors may help overcome drug resistance in melanoma patients

EAST clinical trial to assess early comprehensive rhythm control therapy for AF

Role of molecular imaging in diagnosis and clinical trials

Insight into how brain organizes during development

Posttraumatic stress disorder linked to persistent fears of recurrent SAH

Alcohol, tobacco use increase risk of upper aero-digestive tract cancers

Mood-related brain protein linked to sadness during cigarette withdrawal

Double-lung transplant survivor stays busy since retirement

Combination of six common QA measures could prevent radiotherapy errors

Considerations for taking ASO discovery programs into animal models

Neurofilament light as a translational biomarker

How can machine learning accelerate neuroscience behavior studies?

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