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Article outlines role of transcriptional mutagenesis in tumor development

DNA provides the instruction manual for all life forms. Occasionally, instructions are not carried out properly, and bad messages are sent leading to the creation of mutant proteins and possible tumor development.

5 Mar 2011

Research roundup: Hospital infections and costs; Prescription confusion; Medicaid and access to care

"Sepsis affects approximately 750,000 patients each year in the United States and is in many ways a model condition for examining the relationship between hospital spending and patient outcomes and for identifying potential opportunities to improve the value of hospital care," write the authors.

5 Mar 2011

Combination therapy may reduce albuminuria in patients with type 2 diabetes: Study

Results from a Phase 2, 8-week dose-ranging study using low doses of atrasentan in patients with diabetic kidney disease were published this week in the Journal of the American Society of Nephrology. The published study results suggest that atrasentan, used in conjunction with renin-angiotensin system inhibitors, may reduce albuminuria (presence of protein in urine) for patients with type 2 diabetes.

5 Mar 2011

Pfizer's ORAL Sync Phase 3 study of tofacitinib in moderate-to-severe RA meets primary endpoints

Pfizer Inc. today announced that the ORAL Sync Phase 3 study of tofacitinib, formerly known as tasocitinib, an investigational, novel, oral JAK inhibitor, being studied in moderate-to-severe rheumatoid arthritis, met its primary endpoints by showing statistically significant changes versus placebo in reducing signs and symptoms of RA, as measured by ACR20 response rates at six months; in improving physical function, as measured by mean change in HAQ DI at three months; and in reaching DAS28-4 <2.6 at six months.

5 Mar 2011

Study: Overweight adolescents may have high risk of less bone mass

Overweight adolescents already struggling with risk factors such as insulin resistance may need to add weak bones to their list of health concerns, researchers report.

5 Mar 2011

Family-assisted exercise therapy improves function, recovery after stroke: Study

Your family's involvement in your exercise therapy could significantly improve your function and recovery after stroke, according to a study in the March print issue of Stroke: Journal of the American Heart Association.

5 Mar 2011

OHSU receives NTI grant to study TEG for blood-clot prevention in obese trauma patients

Martin Schreiber, M.D., of Oregon Health & Science University, received a research grant worth nearly $700,000 from the National Trauma Institute to study a method that could more accurately determine how much blood-clot prevention medication to give critically ill or obese trauma patients.

5 Mar 2011

Topamax medication during pregnancy can lead to increased risk of oral birth defects in babies

New data suggest that the drug Topamax and its generic versions increase the risk for the birth defects cleft lip and cleft palate in babies born to women who use the medication during pregnancy, the U.S. Food and Drug Administration said today.

5 Mar 2011

Brain enzyme can restore even old, fading memories, say researchers

Even long after it is formed, a memory in rats can be enhanced or erased by increasing or decreasing the activity of a brain enzyme, say researchers supported, in part, by the National Institutes of Health.

4 Mar 2011

Bariatric surgery can reduce significant weight in severely obese adolescents

"Bariatric surgery" refers to several different surgical procedures designed to assist weight loss by limiting the amount of food someone eats or the amount they absorb during digestion. It has been used for several years to treat obesity in adults.

4 Mar 2011

Doctors at Beaumont Hospital, Troy perform robotic-assisted maze procedure to correct atrial fibrillation

Doctors at Beaumont Hospital, Troy have performed Michigan's first minimally invasive robotic procedure to correct atrial fibrillation, a prevalent and growing heart rhythm disorder. The new robotic maze procedure is an alternative to open-heart surgery. It's performed through tiny, keyhole incisions with fewer complications and a shorter hospital stay.

4 Mar 2011

Scientist discovers new mechanism for regulation of gene expression

Dr. David Levin, Professor of Molecular & Cell Biology at Boston University Henry M. Goldman School of Dental Medicine and Professor of Microbiology at Boston University School of Medicine discovered recently a novel, evolutionarily conserved mechanism for the regulation of gene expression.

4 Mar 2011

Study: Resveratrol can reduce body fat

For her thesis entitled Conjugated Linoleic Acid and Resveratrol: the effect of these functional ingredients on the metabolism of triglycerides and adiposity, Nutrition and Obesity research team member at the University of the Basque Country, Ms Arrate Lasa, studied the fat-reducing effect of CLA and resveratrol.

4 Mar 2011

Medtronic launches Achieve Mapping Catheter in Europe

Medtronic, Inc. today announced the European launch of the Achieve Mapping Catheter, an intra-cardiac electrophysiology recording catheter that can be used to assess pulmonary vein isolation when treating paroxysmal atrial fibrillation.

4 Mar 2011

Alcohol, marijuana and methamphetamines are common abuse substances

A new study shows that the most commonly abused substances among those 18 and older referred to substance abuse treatment from parole or probation was alcohol, followed by marijuana and methamphetamines.

4 Mar 2011

Dramatic decrease in CP diagnoses provides evidence of quality of neonatal care

Cerebral palsy is a neurodevelopmental condition that affects motor function, more often in children born prematurely. Because cerebral palsy is a result of brain injury received shortly before, during, or soon after birth, the number of infants being diagnosed with the condition is a good indicator of the quality of perinatal and neonatal care.

4 Mar 2011

Endolymphatic sac shunt surgery improved hearing loss symptoms in flight attendant

When fluctuating hearing loss, with frequent bouts of nausea and vertigo caused New York flight attendant Patricia Gilbert to miss several work shifts, she sought answers from the medical community.

4 Mar 2011

Uofl professor to create new statistical model for cancer research

A University of Louisville professor is developing a statistical model that, among other things, may help determine what prolongs cancer free survival.

4 Mar 2011

NSBRI selects Brigham researcher for postdoctoral fellowship

Christopher J. Morris, PhD, of the Division of Sleep Medicine at Brigham and Women's Hospital, is one of four scientists selected by the National Space Biomedical Research Institute for a postdoctoral fellowship.

4 Mar 2011

Researchers investigate why immune system is blunted after spinal cord injury

Mobility is a challenge for spinal cord injured patients. Infection is another. Adam Thrasher, assistant professor of health and human performance, says infection is the leading cause of death for people living with spinal cord injuries for two years or more.

4 Mar 2011

Medical Condition News

Article outlines role of transcriptional mutagenesis in tumor development

Research roundup: Hospital infections and costs; Prescription confusion; Medicaid and access to care

Combination therapy may reduce albuminuria in patients with type 2 diabetes: Study

Pfizer's ORAL Sync Phase 3 study of tofacitinib in moderate-to-severe RA meets primary endpoints

Study: Overweight adolescents may have high risk of less bone mass

Family-assisted exercise therapy improves function, recovery after stroke: Study

OHSU receives NTI grant to study TEG for blood-clot prevention in obese trauma patients

Topamax medication during pregnancy can lead to increased risk of oral birth defects in babies

Brain enzyme can restore even old, fading memories, say researchers

Bariatric surgery can reduce significant weight in severely obese adolescents

Doctors at Beaumont Hospital, Troy perform robotic-assisted maze procedure to correct atrial fibrillation

Scientist discovers new mechanism for regulation of gene expression

Study: Resveratrol can reduce body fat

Medtronic launches Achieve Mapping Catheter in Europe

Alcohol, marijuana and methamphetamines are common abuse substances

Dramatic decrease in CP diagnoses provides evidence of quality of neonatal care

Endolymphatic sac shunt surgery improved hearing loss symptoms in flight attendant

Uofl professor to create new statistical model for cancer research

NSBRI selects Brigham researcher for postdoctoral fellowship

Researchers investigate why immune system is blunted after spinal cord injury

The CAR T Veteran: A Journey of Resilience, Remission, and Advocacy

Innovating for impact: Jordi Labs on aligning methodologies with FDA expectation

Exploring the role of confocal-based high-content imaging in advancing core facilities

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