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Study suggests balance between NF-kB and p53 signaling as a promising target for new cancer drugs

A new report published in the October 2010 print issue of The FASEB Journal offers a ray of hope in the search for new cancer drugs. By examining the seemingly conflicting roles of how oncogenes and tumor suppressor genes handle cellular stress, scientists from the Institute for Advanced Studies in New Jersey argue that each of these opposing systems could be potent drug targets in the effort to stop cancer. In addition, their hypothesis provides new insights into what contributes to immunological disorders such as chronic inflammation and autoimmune diseases.

1 Oct 2010

Increase in excise taxes and state-of-the-art tobacco control program reduces lung cancer rates

A study led by researchers at the University of California, San Diego shows that California's 40 year-long tobacco control program has resulted in lung cancer rates that are nearly 25 percent lower than other states.

1 Oct 2010

Report finds development of multiple myeloma is tied to 'hypomethylation'

DNA methylation - a modification of DNA linked to gene regulation - is altered with increasing severity in a blood cancer called multiple myeloma, according to a study by Mayo Clinic and the Translational Genomics Research Institute (TGen).

1 Oct 2010

Global phase IV study confirms efficacy of erlotinib in treatment of non-small cell lung cancer

Featured in the October edition of the Journal of Thoracic Oncology (JTO), data from The Tarceva Lung Cancer Survival Treatment (TRUST) confirms the safety and efficacy profile of erlotinib, a highly potent oral active, reversible inhibitor of epidermal growth factor receptor (EGFR) tyrosine-kinase (TK) activity in a large heterogeneous non-small cell lung cancer (NSCLC) population.

1 Oct 2010

Researchers study potential of menstrual blood-derived stem cells for stroke therapy

The potential for stem cells derived from menstrual blood to benefit stroke sufferers will be jointly investigated by researchers at the University of South Florida, Cryo-Cell International, Inc., a global stem cell company based in Oldsmar, FL, and Saneron CCEL Therapeutics, Inc. a Tampa-based biotechnology company.

1 Oct 2010

UAB Comprehensive Cancer Center wins $11.5M grant for pancreatic cancer research

The University of Alabama at Birmingham Comprehensive Cancer Center, in collaboration with the University of Minnesota, has won an $11.5 million grant from the National Cancer Institute to explore groundbreaking pancreatic cancer research, prevention and treatment.

1 Oct 2010

FDA takes action against unapproved single-ingredient oral colchicine

The U.S. Food and Drug Administration took action against companies that manufacture, distribute, and/or market unapproved single-ingredient oral colchicine, a medication commonly used for the daily prevention of gout, to treat acute gout flare-ups, and for the treatment of Familial Mediterranean Fever (FMF).

1 Oct 2010

DMC recommends continuation of enrollment in Celsion's Phase III ThermoDox HEAT study for primary liver cancer

Celsion Corporation, a leading oncology drug development company, announced that after reviewing data from 401 patients enrolled in its pivotal Phase III ThermoDox ® clinical study (the HEAT study) for primary liver cancer, the Data Monitoring Committee (DMC) has unanimously recommended that the trial continue to enroll patients with the goal of reaching the 600 patients required to complete the study.

1 Oct 2010

Headaches, back pain and arthritis cost companies more than $61 billion per annum

Headaches, back pain, arthritis and other aches distract employees and cost companies more than $61 billion a year in lost productive time, according to a study published in the Journal of the American Medical Association.

1 Oct 2010

CSHL professor receives NIH grant to study mechanism behind autism and schizophrenia

Anthony Zador, Ph.D., Professor of Biology and Program Chair in Neuroscience at Cold Spring Harbor Laboratory (CSHL), has been awarded a $2.17 million, 5-year grant by the National Institutes of Health (NIH)'s Transformative Research Projects Program (T-R01).

1 Oct 2010

Researchers discover key leukemia defense mechanism

Virginia Commonwealth University Massey Cancer Center researcher Steven Grant, M.D., and a team of VCU Massey researchers have uncovered the mechanism by which leukemia cells trigger a protective response when exposed to a class of cancer-killing agents known as histone deacetylase inhibitors (HDACIs).

1 Oct 2010

Family and friends may pose the greatest threat to caregivers' health and well-being

The biggest cause of stress for people who care for loved ones after a stroke may not be worrying about the affected family member.

1 Oct 2010

South Asian ethnicity is a risk factor for cardiovascular events after renal transplantation

Ethnicity is a contributing risk factor of cardiovascular problems in kidney recipients of South Asian origin post-transplant, according to a study appearing in an upcoming issue of the Clinical Journal of the American Society Nephrology (CJASN).

1 Oct 2010

Arthritis Foundation applauds House for passing bipartisan arthritis legislation

The Arthritis Foundation applauds the U.S. House of Representatives for passing the Arthritis Prevention, Control and Cure Act (H.R. 1210/S.984), the first comprehensive, bipartisan arthritis legislation in more than 30 years.

1 Oct 2010

Albert Einstein College of Medicine receives grant to study role of proteins in health and disease

The National Institute of General Medical Sciences (NIGMS) has awarded Albert Einstein College of Medicine of Yeshiva University a five-year, $30 million grant to study the structure and function of thousands of biomedically important proteins.

1 Oct 2010

Maven Semantic updates gastroesophageal reflux research database

The new database is now available to marketing, business development, competitor intelligence, KOL, medical affairs and related departments in the life sciences sector.

1 Oct 2010

Personalized cancer drug delivery could soon be a reality

Imagine the day a machine can draw your blood, screen it for genetic mutations and chemical variations that can cause cancer, and pop out a drug tailor-made for your DNA.

1 Oct 2010

Researchers discover new factors that regulate fat formation

By creating a "map" of histone modifications in fat cells, investigators have discovered two new factors that regulate fat formation, a key step on the road to better understanding obesity, diabetes and other metabolic disorders.

1 Oct 2010

School vending machines can influence students' dietary choices

With over 23 million children and adolescents in the US overweight or obese, the risks for many chronic diseases continue to increase. An article in the October issue of the Journal of the American Dietetic Association examines the diets of American youth and finds some disturbing results.

1 Oct 2010

Candidates who have strong religious connection have better post-transplant survival

Italian researchers report that liver transplant candidates who have a strong religious connection have better post-transplant survival. This study also finds that religiosity—regardless of cause of death—prolongs the life span of individuals who underwent liver transplantation.

1 Oct 2010

Medical Condition News

Study suggests balance between NF-kB and p53 signaling as a promising target for new cancer drugs

Increase in excise taxes and state-of-the-art tobacco control program reduces lung cancer rates

Report finds development of multiple myeloma is tied to 'hypomethylation'

Global phase IV study confirms efficacy of erlotinib in treatment of non-small cell lung cancer

Researchers study potential of menstrual blood-derived stem cells for stroke therapy

UAB Comprehensive Cancer Center wins $11.5M grant for pancreatic cancer research

FDA takes action against unapproved single-ingredient oral colchicine

DMC recommends continuation of enrollment in Celsion's Phase III ThermoDox HEAT study for primary liver cancer

Headaches, back pain and arthritis cost companies more than $61 billion per annum

CSHL professor receives NIH grant to study mechanism behind autism and schizophrenia

Researchers discover key leukemia defense mechanism

Family and friends may pose the greatest threat to caregivers' health and well-being

South Asian ethnicity is a risk factor for cardiovascular events after renal transplantation

Arthritis Foundation applauds House for passing bipartisan arthritis legislation

Albert Einstein College of Medicine receives grant to study role of proteins in health and disease

Maven Semantic updates gastroesophageal reflux research database

Personalized cancer drug delivery could soon be a reality

Researchers discover new factors that regulate fat formation

School vending machines can influence students' dietary choices

Candidates who have strong religious connection have better post-transplant survival

Transforming Cardiovascular Care: Insights from Mina Makar at AstraZeneca

Clue's CEO Rhiannon White on the Future of Femtech and PCOS

Freezing Point Osmometry in Life Science Applications

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