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Key RNA pathway controlling DNA packaging and cancer progression

Inside every cell, inside every nucleus, your continued existence depends on an incredibly complicated dance. Proteins are constantly wrapping and unwrapping DNA, and even minor missteps can lead to cancer.

3 Oct 2024

The impact of KRAS mutations on pancreatic cancer progression and survival

A common mutation in the KRAS gene is associated with improved overall survival in pancreatic ductal adenocarcinoma (PDAC) compared with other variants, in part because the mutation appears to lead to less invasiveness and weaker biological activity, according to a multicenter study conducted at Weill Cornell Medicine, NewYork-Presbyterian, Memorial Sloan Kettering Cancer Center, and other institutions.

3 Oct 2024

Bioelectronic 'living pharmacy' implant could transform diabetes and obesity care

A Carnegie Mellon University-led team of researchers has secured an award of up to $34.9 million from the Advanced Research Projects Agency for Health (ARPA-H).

3 Oct 2024

Implantable device revolutionizes thyroid management

A Carnegie Mellon University-led team has secured an award of up to $42 million from the Advanced Research Projects Agency for Health (ARPA-H) to accelerate the development of implantable, cell-based bioelectronic devices that deliver patient-specific therapy and monitor disease status, for conditions like hypo- and hyperthyroidism, in real time.

3 Oct 2024

Using advanced AI screening tools to improve early detection of myopic maculopathy

Myopia, also known as nearsightedness, is on the rise, especially among children.

3 Oct 2024

SWOG S1011 trial questions the benefits of extended lymphadenectomy in bladder cancer

The SWOG S1011 randomized phase 3 trial found no significant improvement in disease-free or overall survival but a higher rate of grade 3-4 adverse events and an increased risk of death in the 90 days after surgery.

3 Oct 2024

Scientists overcome major challenge in gene therapy and drug delivery

Imagine trying to poke a hole in the yolk of a raw egg without breaking the egg white. It sounds impossible, but researchers at the University of California San Diego have developed a technology that performs a similarly delicate task in living cells. They created an array of nanopillars that can breach the nucleus of a cell-;the compartment that houses our DNA-;without damaging the cell's outer membrane.

3 Oct 2024

Mediterranean diet significantly lowers heart failure risk, especially in women

Increased adherence to the Mediterranean diet significantly lowers the risk of heart failure, especially in women, according to a recent European meta-analysis. The diet's anti-inflammatory and antioxidant properties are key to its protective effects.

3 Oct 2024

Circadian rhythm influences dementia diagnosis and disease progression

The time of day when blood is taken can affect the results of tests for diagnosing dementia, according to new research led by the University of Surrey.

3 Oct 2024

Creating a tobacco-free generation could prevent 1.2 million lung cancer deaths

Creating a generation of people who never smoke could prevent 1.2 million deaths from lung cancer globally, according to a study led by researchers from the University of Santiago de Compostela, the International Agency for Research on Cancer (IARC), and global collaborators published in The Lancet Public Health journal.

3 Oct 2024

UCLA develops CORE score to assess surgical mortality risk

A UCLA research team has created the Comorbid Operative Risk Evaluation (CORE) score to better account for the role chronic illness plays in patient's risk of mortality after operation, allowing surgeons to adjust to patients' pre-existing conditions and more easily determine mortality risk.

3 Oct 2024

Depression and anxiety diagnoses in youth spiked during the COVID-19 pandemic

Researchers analyzed clinical data from over 1.7 million young people, revealing significant increases in diagnosed depression and anxiety from 2017 to 2021, with higher rates during the COVID-19 pandemic.

2 Oct 2024

New treatment proposed for brain metastases resistant to immunotherapy

Researchers at the Spanish National Cancer Research Centre (CNIO) propose a new treatment for brain metastases that respond poorly, or not at all, to immunotherapy, and provide a biomarker to predict in which cases it should be used.

2 Oct 2024

Reducing sedentary time found effective in preventing worsening back pain

A new study from the University of Turku in Finland showed that reducing daily sitting prevented back pain from worsening over six months.

2 Oct 2024

New study could lead to a more potent treatment option for multiple sclerosis

Multiple Sclerosis (MS) is a long-term disease where the immune system mistakenly attacks the protective layer around nerve cells, known as the myelin sheath.

2 Oct 2024

Nanocapsules for glucagon offer a new approach to prevent hypoglycemia

People with diabetes take insulin to lower high blood sugar. However, if glucose levels plunge too low -; from taking too much insulin or not eating enough sugar -; people can experience hypoglycemia, which can lead to dizziness, cognitive impairment, seizures or comas.

2 Oct 2024

Dronabinol shows promise in reducing agitation in Alzheimer's patients

In a study led by the Johns Hopkins University School of Medicine and Tufts University School of Medicine, researchers show that a pill form of the drug dronabinol, an FDA-approved synthetic version of marijuana's main ingredient, THC, reduces agitation in patients with Alzheimer's by an average of 30%.

2 Oct 2024

Frailty linked to diminished quality of life in cancer and transplant survivors

A new research paper was published on the in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science), Volume 16, Issue 18 on September 26, 2024, entitled, "Frailty and pre-frailty associated with long-term diminished physical performance and quality of life in breast cancer and hematopoietic cell transplant survivors."

2 Oct 2024

NYU Langone secures NIH award to explore eye imaging for early detection of Alzheimer's and Parkinson's

Researchers at NYU Langone Health were awarded $1.6 million from the National Institutes of Health (NIH) to investigate changes in the eye that may indicate early signs of Alzheimer's disease and Parkinson's disease.

2 Oct 2024

Online insomnia treatment brings relief to overburdened caregivers

Providing care for a family member with a disabling illness can be a demanding job that leaves many people unable to sleep, but an online insomnia treatment developed at the University of Virginia School of Medicine can help, new research shows.

2 Oct 2024