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Researchers demonstrate role of HSP-90 in portal hypertension

Neural vasoregulation represents a rapid and potent mode of altering vascular tone but has not been investigated thoroughly during portal hypertension. Heat shock protein-90 is well-known to act as a molecular chaperone optimizing endothelial and neural NO-synthase enzyme activity and thus, NO production.

21 Apr 2010

Findings may illuminate how cancer forms and migrates

Rho proteins have been described as "molecular switches" and play a role in cell migration, cell proliferation, cell death, gene expression, and multiple other common cellular functions.

21 Apr 2010

MMRC Multiple Myeloma Genomics Initiative presented at AACR 2010

An analysis of 38 myeloma tumor genomes surveyed through extensive next-generation sequencing by the Broad Institute has revealed intriguing recurrent mutations that point to important cellular pathways which contribute to multiple myeloma. These data were revealed during an oral presentation entitled "First Impressions of the Multiple Myeloma Genome" by Todd R. Golub, MD, Director of the Cancer Program at the Eli and Edythe L. Broad Institute.

21 Apr 2010

Tea for Teal event raises $15,000 for TGen ovarian cancer research

The Anne Rita Monahan Foundation recently presented $15,000 for ovarian cancer research to the Translational Genomics Research Institute (TGen).

21 Apr 2010

Contrary to previous studies, people with Moebius syndrome lead successful lives

A smile means happiness, a frown sadness, a raised brow surprise. Even when languages and cultures differ, people have this universal form of communication. But Moebius syndrome, a rare congenital condition causing facial paralysis, can rob people of this basic connection, affecting social interaction.

21 Apr 2010

"Destination therapy" for end-stage heart failure patients

Federal approval for an alternative therapy to heart transplantation led to a new lease on life for a UT Southwestern Medical Center patient who suffered from heart failure for nearly a decade.

21 Apr 2010

Modest weight reduction reverses immune cell damage in obese people with diabetes

Australian scientists have shown for the first time that even modest weight loss reverses many of the damaging changes often seen in the immune cells of obese people, particularly those with Type 2 diabetes.

21 Apr 2010

Plexxikon presents promising preclinical data from PLX3397 in vivo cancer studies

Plexxikon Inc. today announced promising preclinical data from in vivo cancer studies with PLX3397 demonstrating significant reduction in tumor burden, metastatic spread, bone erosion and cancer bone pain. PLX3397 is an oral, selective kinase inhibitor that down-modulates macrophages, microglia, osteoclasts and mast cells, all cell types targeted by this drug candidate. These cell types play a key role in cancer and metastasis.

21 Apr 2010

Researchers screen Afro-Caribbean students to predict risk of heart disease

Researchers at the University of Hertfordshire are screening an Afro-Caribbean cohort of students this week to gauge their predisposition to heart disease in later life.

21 Apr 2010

Study shows Inuit children are tall as U.S. counterparts, but are also heavier

Inuit preschoolers in Nunavut are as tall as their U.S. counterparts but they're also heavier, according to a new study published in the online edition of the International Journal of Circumpolar Health.

21 Apr 2010

Gene test predicts statins' effectiveness in reducing risk of colorectal cancer

A genetic test can help determine in which patients cholesterol-lowering statin drugs might have the most benefit in also reducing the risk of colorectal cancer, a new study from researchers at the University of Michigan Comprehensive Cancer Center finds.

21 Apr 2010

Vitamin D intake from foods, supplements may not predict relationship between cancer and vitamin D

Vitamin supplements, diet, geographic location, demographic information or lifestyle, independently or in combination, cannot accurately predict vitamin D concentrations in blood, researchers at the University at Buffalo have found.

21 Apr 2010

Decrease in breast density linked to reduced risk of breast cancer

A decrease in breast density, or the proportion of fibroglandular tissue depicted on the mammogram image, over a number of years is associated with decreased risk of breast cancer, researchers from the Mayo Clinic campus in Minnesota report at the American Association for Cancer Research (AACR) 101st Annual Meeting 2010.

21 Apr 2010

Systems biologists integrate new genetic framework to help predict adverse drug reactions

In a major step toward predicting adverse drug reactions, systems biologists at Mount Sinai School of Medicine in New York City have integrated genetic, cellular and clinical information to find out why certain medicines can trigger fatal heart arrhythmias.

21 Apr 2010

Relative importance of genetic factors is low in tinnitus, says new research

The relative importance of genetic factors in tinnitus is low, according to new research from the Norwegian Institute of Public Health. This is the first large population-based study to measure the heritability of tinnitus.

21 Apr 2010

miRNAs may generate new insights on cancer and possible future treatments

Scientists are methodically unlocking the biological processes that lead to cancer, and recent discoveries with microRNAs (miRNAs) are revolutionizing their understanding and leading to clinical trials of potentially effective treatments.

21 Apr 2010

Listening to personal music players can induce hearing loss

Young people who listen to personal music players for several hours a day at high volume could be putting their hearing at risk, warns an expert in an editorial published on bmj.com today.

21 Apr 2010

Scientists suggest link between well-cooked meat and increased risk of bladder cancer

US scientists have suggested a link between eating well-done meat and a slightly increased risk of bladder cancer. But a Cancer Research UK spokesperson urged caution over the results.

21 Apr 2010

CSTE receives $1M gift from NFL to research long-term effects of repetitive brain trauma in football players

The National Football League (NFL) will give a $1 million unrestricted gift to the Center for the Study of Traumatic Encephalopathy (CSTE) at Boston University School of Medicine to support the Center's research.

21 Apr 2010

Lotus Pharmaceuticals' asthma drug Laevo-Bambutero to receive Chinese SFDA Fast Track Approval

Lotus Pharmaceuticals, Inc., a growing developer, manufacturer and seller of medicine and drugs in the People's Republic of China reported that its asthma drug Laevo-Bambutero will receive the China's State Food & Drug Administration's (SFDA) Fast Track Approval to enter clinical trials. The SFDA's Drug Review and Evaluation Center told the Company during recent consultations at the end of the Company's IND that formal approval would be granted by the Beijing office of the SFDA.

21 Apr 2010

Medical Condition News

Researchers demonstrate role of HSP-90 in portal hypertension

Findings may illuminate how cancer forms and migrates

MMRC Multiple Myeloma Genomics Initiative presented at AACR 2010

Tea for Teal event raises $15,000 for TGen ovarian cancer research

Contrary to previous studies, people with Moebius syndrome lead successful lives

"Destination therapy" for end-stage heart failure patients

Modest weight reduction reverses immune cell damage in obese people with diabetes

Plexxikon presents promising preclinical data from PLX3397 in vivo cancer studies

Researchers screen Afro-Caribbean students to predict risk of heart disease

Study shows Inuit children are tall as U.S. counterparts, but are also heavier

Gene test predicts statins' effectiveness in reducing risk of colorectal cancer

Vitamin D intake from foods, supplements may not predict relationship between cancer and vitamin D

Decrease in breast density linked to reduced risk of breast cancer

Systems biologists integrate new genetic framework to help predict adverse drug reactions

Relative importance of genetic factors is low in tinnitus, says new research

miRNAs may generate new insights on cancer and possible future treatments

Listening to personal music players can induce hearing loss

Scientists suggest link between well-cooked meat and increased risk of bladder cancer

CSTE receives $1M gift from NFL to research long-term effects of repetitive brain trauma in football players

Lotus Pharmaceuticals' asthma drug Laevo-Bambutero to receive Chinese SFDA Fast Track Approval

How can microdialysis benefit drug development

Global and Local Efforts to Take Action Against Hepatitis

Addressing Important Cardiac Biology Questions with Shotgun Top-Down Proteomics

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