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Novel intermediate form of serotonin receptor identified as therapeutic target for psychiatric disorders

Misha Kudryshev's lab at the Max Delbrück Center has identified a molecular intermediate of a serotonin receptor that is involved in diseases such as depression and schizophrenia.

4 Sep 2024

Study uncovers key enzyme link between obesity and atrial fibrillation

A cellular link between obesity and atrial fibrillation -; a heart condition that afflicts over 33 million people worldwide -; presents a promising target for new therapies, researchers from the University of Illinois Chicago report.

4 Sep 2024

New immunotherapy approach shows promise for minimizing spinal cord injury damage

WashU Medicine researchers have designed, in mice, an approach to minimizing the damage from a spinal cord injury through the use of engineered immune cells.

4 Sep 2024

Evaluating underwater endoscopic mucosal resection for gastrointestinal neuroendocrine tumors

Neuroendocrine tumors (NETs) of the gastrointestinal (GI) tract are a rare and heterogeneous group of malignancies arising from the neuroendocrine cell system.

4 Sep 2024

Regular mobile phone use linked to increased cardiovascular disease risk in smokers and diabetics

A new study has found that regular mobile phone use was positively associated with incident cardiovascular diseases risk, especially in current smokers and individuals with diabetes. In addition, this association was partly attributed to poor sleep, psychological distress, and neuroticism.

4 Sep 2024

Sports concussions may not be related to long-term cognitive risks for non-professional athletes

Sports-related concussions (SRC) may not be associated with long-term cognitive risks for non-professional athletes, a study led by a UNSW medical researcher suggests.

4 Sep 2024

Semaglutide does not increase risk of depression or suicidal thoughts

Taking the weight loss medication semaglutide did not increase the risk of depressive symptoms, suicidal thoughts, or suicidal behavior in persons without known major mental health disorders, according to a new study led by researchers from the Perelman School of Medicine at the University of Pennsylvania published this week in JAMA Internal Medicine.

4 Sep 2024

Lifestyle interventions in patients after colorectal cancer treatment

A recent RCT reveals the HEAL ABC intervention is feasible for 87% of colorectal cancer survivors, supporting healthy lifestyle changes and improved well-being.

4 Sep 2024

Understanding the impact of BMI on colorectal cancer risk in Asia

Researchers report that body mass index values in Asians population may predict the risk of developing colorectal cancer.

4 Sep 2024

Does air pollution drive dementia?

Chronic air pollution exposure is a key factor in dementia development, with pollutants like PM2.5 and NO2 linked to cognitive decline and neurodegeneration.

4 Sep 2024

Sleep too much or too little? Your cognition pays the price

Findings indicate that both insufficient and excessive sleep are linked to higher mild cognitive impairment risk, underscoring the importance of balanced sleep.

4 Sep 2024

Scientists uncover shared gene expression patterns in aging and psychiatric disorders

Researchers reveal how aging and psychiatric disorders converge at the cellular level in the orbitofrontal cortex, identifying key gene expression changes that could lead to new therapies.

4 Sep 2024

Alzheimer's disease: $14.5 trillion burden on global economy by 2050

Study estimates that Alzheimer's disease and other dementias will cost the global economy $14.5 trillion by 2050, disproportionately impacting high-income countries. Researchers call for urgent global action to mitigate this rising economic burden.

4 Sep 2024

A novel therapeutic option for HER2-positive extramammary Paget disease

The research article presents a comprehensive evaluation of the human epidermal growth factor receptor 2 (HER2) status in extramammary Paget disease (EMPD) and explores the therapeutic potential of disitamab vedotin (DV), a novel humanized anti-HER2 antibody-drug conjugate (ADC), for this rare adenocarcinoma.

4 Sep 2024

Ultra-processed foods significantly raise heart disease risk

Higher intake of ultra-processed foods is linked to increased risks of coronary heart disease and cardiovascular disease in U.S. adults, with certain processed foods like meats and sugary drinks posing significant dangers.

4 Sep 2024

Seasonal patterns in Valley fever cases reveal climate-driven risks

Valley fever is an emerging fungal disease in the western United States that most often causes flu-like symptoms, but can also cause dangerous or even deadly complications. By analyzing data on reported cases of Valley fever in California, which have increased dramatically over the last two decades, researchers from the University of California San Diego and the University of California, Berkeley, have identified seasonal patterns that could help individuals and public health officials better prepare for future surges in Valley fever cases.

4 Sep 2024

New approach to treat post-COVID symptoms

In a world still grappling with the aftermath of the COVID-19 pandemic, a team of international researchers has proposed a novel approach to treating the persistent symptoms that plague many survivors of viral infections. The study, published on 30 August 2024 in Brain Medicine (ISSN: 2997-2639, Genomic Press, New York), outlines a multimodal treatment strategy that could offer hope to millions suffering from post-acute infectious syndromes (PAIS), including the condition commonly known as Long COVID.

4 Sep 2024

Alirocumab reduces dangerous coronary plaque and stabilizes high-risk lesions

Intensive LDL-C lowering with alirocumab significantly reduces high-risk coronary plaque burden, transforming unstable plaques into more stable phenotypes. This lesion-level analysis underscores the enhanced efficacy compared to vessel-level approaches.

4 Sep 2024

Understanding the risks for young mothers in child care proceedings

Mothers under the age of 20 are at the greatest risk of being involved in care proceedings in the 10 years after having their first child, finds a new study report led by UCL researchers.

4 Sep 2024