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Study assesses effect of chemoradiotherapy on survival of locally advanced pancreatic cancer patients

In a study appearing in the May 3 issue of JAMA, Pascal Hammel, M.D., of Beaujon Hospital, Clichy, France and colleagues assessed whether chemoradiotherapy improves overall survival of patients with locally advanced pancreatic cancer controlled after 4 months of gemcitabine-based induction chemotherapy, and assessed the effect of erlotinib on survival. Gemcitabine and erlotinib are drugs used to treat cancer.

4 May 2016

Young breast cancer patients see body changes more positively after mastectomy treatment

BODY image identity varies among women who have undergone treatment for breast cancer with many rejecting mainstream body shape ideals, research shows.

4 May 2016

New EU project aims to develop models that can help predict behavior of cancer-related signaling pathways

A group of scientists at Helmholtz Zentrum München will engage in a new project promoted by the EU. The scientists in the team of Dr. Jan Hasenauer, head of the young investigator group 'Data-driven Computational Modeling' work as part of CanPathPro.

4 May 2016

Researchers identify 43 specific genes associated with both autism and cancer

Autism and cancer share more than 40 risk genes, suggesting that common mechanisms underlying the functions of some of these genes could conceivably be leveraged to develop therapies not just for cancer but for autism as well, an extensive assessment by researchers with the UC Davis MIND Institute and Comprehensive Cancer Center has found.

4 May 2016

Researchers develop molecule that binds to GAA enzymes key to progress of Pompe disease

Researchers at Leiden University have made a breakthrough in the study of the hereditary Pompe disease. Together with colleagues in York, they have developed a molecule that binds to the enzyme that is key to the progress of the disease. The findings have been published in ACS Central Science.

4 May 2016

Study shows syringe-like device acts as traffic cop directing bacteria to carry out infection

A study has found that a syringe-like device used to invade intestinal cells also acts as a traffic cop -- directing bacteria where to go and thereby enabling them to efficiently carry out infection.

4 May 2016

Riluzole drug can reverse key genetic changes linked to Alzheimer's disease

Aging takes its toll on the brain, and the cells of the hippocampus--a brain region with circuitry crucial to learning and memory--are particularly vulnerable to changes that can lead to Alzheimer's disease or cognitive decline. With the hope of counteracting the changes that can lead to these two conditions, researchers at Rockefeller University and their colleagues have begun examining the effects of a drug known to affect this circuitry.

4 May 2016

Depression, anxiety co-occur in bipolar disorder patients following mania

Adults with bipolar disorder are just as likely to develop anxiety as depression following an episode of mania, according to data from a national survey of more than 34,000 adults. This finding, published today in Molecular Psychiatry, may expand our understanding of bipolar disorder to include anxiety.

4 May 2016

Lumbar drain placement lowers postoperative CSF leak rate for patients undergoing endoscopic endonasal surgery

Winner of the Synthes Skull Base Award, Nathan T. Zwagerman, MD, presented his research, A Prospective, Randomized Control Trial for Lumbar Drain Placement after Endoscopic Endonasal Skull Base Surgery, during the 2016 American Association of Neurological Surgeons Annual Scientific Meeting.

4 May 2016

Study finds link between placenta and offspring bone

Researchers at the Medical Research Council Lifecourse Epidemiology Unit, University of Southampton, studied 518 children in the Avon Longitudinal Study of Parents and Children (ALSPAC) who underwent bone scans at nine, 15 and 17 years old. Measurements such as thickness, volume and weight, were also taken from the mothers' placenta.

4 May 2016

New HIV infections and transmission rate in the U.S. drop, but fall short of NHAS goals

The number of new HIV infections and the transmission rate in the United States dropped by 11 and 17 percent, respectively, between 2010 and 2015, but fell short of the goals put forth by President Obama's U.S. National HIV/AIDS Strategy (NHAS), researchers from the Perelman School of Medicine at the University of Pennsylvania and Johns Hopkins Bloomberg School of Public Health reported this week in the journal AIDS and Behavior.

4 May 2016

Biomedical researcher wins 2016 Gutenberg Research Award for work on programmed cell death

The Gutenberg Research College of Johannes Gutenberg University Mainz has chosen to give the 2016 Gutenberg Research Award to American biomedical researcher Dr. Vishva Dixit for his groundbreaking work in the field of programmed cell death.

4 May 2016

NSCLC MAGE-A3 immunotherapy development halted

Disease-free survival is not prolonged with adjuvant MAGE-A3 immunotherapy in patients with surgically resected non-small-cell lung cancer, according to a placebo-controlled trial.

4 May 2016

Cerebellar not cerebral atrophy predicts poor anti-NMDAR encephalitis outcome

Diffuse cerebral atrophy in patients with anti-N-methyl-D-aspartate receptor encephalitis does not necessarily mean irreversible brain damage, whereas progressive cerebellar atrophy may indicate a poor long-term prognosis, researchers report.

4 May 2016

Total cessation of GnRH production by hypothalamic neurons can lead to infertility

Individual small RNAs are responsible for controlling the expression of gonadoliberin or GnRH (Gonadotropin-Releasing Hormone), a neurohormone that controls sexual maturation, the appearance of puberty, and fertility in adults.

3 May 2016

Important changes in social lives of older adults indicate cognitive decline

Small changes in the social lives of older people are early red flags showing that their thought processes and brain functioning could be on the decline. This is according to Ashwin Kotwal of Brigham and Women's Hospital in the US, who led a study¹ in the Journal of General Internal Medicine, published by Springer.

3 May 2016

Understanding effects of freeze-thawing, intravenous delivery on MSC function

Before the therapeutic potential of using human tissue-derived mesenchymal stromal cells (MSC) to treat immune and degenerative diseases can be fully determined, the effects of freeze-thawing and intravenous delivery on MSC function must be understood.

3 May 2016

New investigational inhibitor JQEZ5 can block specific molecular malfunctions driving cancer

In a step forward in the push for targeted treatments that can block the specific molecular malfunctions driving cancer, University of North Carolina Lineberger Comprehensive Cancer Center researchers have demonstrated how a genetic mutation can drive the most common type of lymphoma as well as melanoma, the deadliest form of skin cancer.

3 May 2016

Combination of existing chemotherapy drugs can reduce breast cancer stem cells, improve survival

Two existing chemotherapy drugs appear to be a powerful pair in targeting errant stem cells that are making breast cancer and enabling its spread and recurrence, scientists report.

3 May 2016

Self-reported care delays linked to long waiting times in VA health coverage system

Military veterans are more likely to report delays in seeking necessary healthcare, compared to the US general population, reports a study in the Journal of Public Health Management and Practice. The journal is published by Wolters Kluwer.

3 May 2016

Medical Research News

Study assesses effect of chemoradiotherapy on survival of locally advanced pancreatic cancer patients

Young breast cancer patients see body changes more positively after mastectomy treatment

New EU project aims to develop models that can help predict behavior of cancer-related signaling pathways

Researchers identify 43 specific genes associated with both autism and cancer

Researchers develop molecule that binds to GAA enzymes key to progress of Pompe disease

Study shows syringe-like device acts as traffic cop directing bacteria to carry out infection

Riluzole drug can reverse key genetic changes linked to Alzheimer's disease

Depression, anxiety co-occur in bipolar disorder patients following mania

Lumbar drain placement lowers postoperative CSF leak rate for patients undergoing endoscopic endonasal surgery

Study finds link between placenta and offspring bone

New HIV infections and transmission rate in the U.S. drop, but fall short of NHAS goals

Biomedical researcher wins 2016 Gutenberg Research Award for work on programmed cell death

NSCLC MAGE-A3 immunotherapy development halted

Cerebellar not cerebral atrophy predicts poor anti-NMDAR encephalitis outcome

Total cessation of GnRH production by hypothalamic neurons can lead to infertility

Important changes in social lives of older adults indicate cognitive decline

Understanding effects of freeze-thawing, intravenous delivery on MSC function

New investigational inhibitor JQEZ5 can block specific molecular malfunctions driving cancer

Combination of existing chemotherapy drugs can reduce breast cancer stem cells, improve survival

Self-reported care delays linked to long waiting times in VA health coverage system

CoppaFeel!: Breast Cancer Doesn’t Discriminate, So Why Should Awareness?

The CAR T Veteran: A Journey of Resilience, Remission, and Advocacy

Innovating for impact: Jordi Labs on aligning methodologies with FDA expectation

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