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Air and noise pollution has severe consequences on heart health

Cardiovascular diseases (CVD), including heart disease and stroke, are the no 1 killer worldwide and in Europe, where they cause the death of over 10 000 people daily, i.e. more than all cancers combined.

28 Aug 2015

Proportion of diabetes patients undergoing coronary artery bypass grafting rises from 7% to 37% in 40 years

In the 40 years between 1970-2010, the proportion of patients with diabetes undergoing coronary artery bypass grafting (CABG) escalated from 7% to 37%. The results of a large study from Cleveland Clinic just published in The Journal of Thoracic and Cardiovascular Surgery, the official publication of the American Association for Thoracic Surgery, documents the five-fold increase in the proportion of patients with diabetes undergoing this procedure between 1970 and 2010.

28 Aug 2015

Cell-to-cell transmission of HIV leads to development of AIDS

Researchers from the Gladstone Institutes have revealed that HIV does not cause AIDS by the virus's direct effect on the host's immune cells, but rather through the cells' lethal influence on one another.

28 Aug 2015

UVA researchers reveal how sperm use 'harpoon' to facilitate fertilization

Could the sperm harpoon the egg to facilitate fertilization? That's the intriguing possibility raised by the University of Virginia School of Medicine's discovery that a protein within the head of the sperm forms spiky filaments, suggesting that these tiny filaments may lash together the sperm and its target.

28 Aug 2015

Arthrosurface inlay implant dramatically reduces progression of osteoarthritis

A recent study by Feucht et al, published in the KSSTA Knee Journal, compared the Arthrosurface HemiCAP Wave implant, which is based on an "inlay" Arthroplasty design, versus an "onlay" design implant for isolated patellofemoral disease. While both implant groups showed similar improvements in function and pain scores, none of the patients in the "inlay" group showed progression of osteoarthritis (OA).

28 Aug 2015

Individually tailored treatment may help reduce mortality risk in patients undergoing routine surgeries

Cholecystectomy and treatment for inguinal, femoral, umbilical, or abdominal hernia are common surgeries and are considered routine in Germany. In an original article in the current edition of Deutsches Ärzteblatt International (Dtsch Arztebl Int 112: 535-43), Ulrike Nimptsch and Thomas Mansky show that fewer than 0.5% of patients die as a result of such surgeries.

28 Aug 2015

Scientists uncover mechanism responsible for development of adrenal gland tumors

Scientists at the Helmholtz Zentrum München have elucidated a mechanism that is responsible for the development of adrenal gland tumors. They discovered that the BMP7 protein plays a key role in this process and that it could be a possible target for future treatments. The results have been published in the journal 'Oncotarget'.

28 Aug 2015

Research: Mechanisms behind bacterial warfare could be harnessed to target pathogenic bacteria

Two UC Santa Barbara graduate students have demonstrated how certain microbes exploit proteins in nearby bacteria to deliver toxins and kill them.

28 Aug 2015

Researchers identify druggable target to potentially root out colon cancer, end relapse

Researchers targeting colorectal cancer stem cells - the root cause of disease, resistance to treatment and relapse - have discovered a mechanism to mimic a virus and potentially trigger an immune response to fight the cancer like an infection.

28 Aug 2015

New study provides framework for establishing value-based pricing for new cancer drugs

At a time when cancer drug prices are rising rapidly, an innovative new study provides the framework for establishing value-based pricing for all new oncology drugs entering the marketplace. Using a highly sophisticated economic model, researchers from Winship Cancer Institute of Emory University and Georgia Institute of Technology used an example of a new lung cancer drug.

28 Aug 2015

Pitt researchers identify molecular mechanisms behind resilience to tinnitus, possible drug therapy

Researchers have identified in an animal model the molecular mechanisms behind resilience to noise-induced tinnitus and a possible drug therapy that could reduce susceptibility to this chronic and sometimes debilitating condition. The findings by a team from the University of Pittsburgh School of Medicine were published online in the journal eLife.

28 Aug 2015

Researchers find fatty acid deposits in brains of Alzheimer's patients

People with Alzheimer's disease have fat deposits in the brain. For the first time since the disease was described 109 years ago, researchers affiliated with the University of Montreal Hospital Research Centre (CRCHUM) have discovered accumulations of fat droplets in the brain of patients who died from the disease and have identified the nature of the fat.

28 Aug 2015

Adaptive immune system plays active role in guiding development of mammary glands

In experiments with mouse tissue, UC San Francisco researchers have discovered that the adaptive immune system, generally associated with fighting bacterial and viral infections, plays an active role in guiding the normal development of mammary glands, the only organs--in female humans as well as mice--that develop predominately after birth, beginning at puberty.

28 Aug 2015

Lack of professional guidance on The Physician Payments Sunshine Act may hinder participation in clinical trials

A research article, published today in Postgraduate Medicine, has concluded that a lack of professional guidance on how to interpret elements of The Physician Payments Sunshine Act (2010) may be having a "chilling effect" on physicians' desire to participate in clinical trials and publish results.

28 Aug 2015

New review article reveals Y chromosome’s role in cardiovascular and immune function, cancer

The role of sex in human disease is a growing area of research. Although estrogen (in females) and androgens (in males) are often seen as possible causes for such differences, sex chromosomes, including the male-specific Y chromosome, may also play a role. However, it has been difficult to understand how the Y chromosome could contribute to disease in men, in part because it is much more difficult to sequence than all other chromosomes.

28 Aug 2015

Researchers uncover important cellular functions that help regulate inflammation

Researchers at the Virginia Bioinformatics Institute at Virginia Tech have uncovered key cellular functions that help regulate inflammation -- a discovery that could have important implications for the treatment of allergies, heart disease, and certain forms of cancer.

28 Aug 2015

Brain scans may help predict patients' response to antipsychotic drug treatment

Investigators at The Feinstein Institute for Medical Research have discovered that brain scans can be used to predict patients' response to antipsychotic drug treatment. The findings are published online in the latest issue of The American Journal of Psychiatry.

28 Aug 2015

Brain cells in Parkinson's disease die prematurely, burning out like an overheating motor

The death of brain cells in Parkinson's disease may be caused by a form of cellular energy crisis in neurons that require unusually high quantities of energy to carry out their job of regulating movement, researchers at the University of Montreal reported today.

28 Aug 2015

History of oral contraceptive use influences survival in ovarian cancer patients

A history of oral contraceptive use and having at least one child increased longevity by nearly three years in patients diagnosed with ovarian cancer, according to a Roswell Park Cancer Institute study recently published online ahead of print in the International Journal of Gynecological Cancer.

28 Aug 2015

SLU study finds that length of stay in ED makes no real difference in mortality of trauma patient

The amount of time a trauma patient stays in the emergency department (ED) makes no real difference in the patient's mortality, researchers at Saint Louis University found in a recent study.

28 Aug 2015

Medical Research News

Air and noise pollution has severe consequences on heart health

Proportion of diabetes patients undergoing coronary artery bypass grafting rises from 7% to 37% in 40 years

Cell-to-cell transmission of HIV leads to development of AIDS

UVA researchers reveal how sperm use 'harpoon' to facilitate fertilization

Arthrosurface inlay implant dramatically reduces progression of osteoarthritis

Individually tailored treatment may help reduce mortality risk in patients undergoing routine surgeries

Scientists uncover mechanism responsible for development of adrenal gland tumors

Research: Mechanisms behind bacterial warfare could be harnessed to target pathogenic bacteria

Researchers identify druggable target to potentially root out colon cancer, end relapse

New study provides framework for establishing value-based pricing for new cancer drugs

Pitt researchers identify molecular mechanisms behind resilience to tinnitus, possible drug therapy

Researchers find fatty acid deposits in brains of Alzheimer's patients

Adaptive immune system plays active role in guiding development of mammary glands

Lack of professional guidance on The Physician Payments Sunshine Act may hinder participation in clinical trials

New review article reveals Y chromosome’s role in cardiovascular and immune function, cancer

Researchers uncover important cellular functions that help regulate inflammation

Brain scans may help predict patients' response to antipsychotic drug treatment

Brain cells in Parkinson's disease die prematurely, burning out like an overheating motor

History of oral contraceptive use influences survival in ovarian cancer patients

SLU study finds that length of stay in ED makes no real difference in mortality of trauma patient

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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