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Iron accumulation in human tissues may contribute to the aging process

It's been known for decades that some metals, including iron, accumulate in human tissues during aging and that toxic levels of iron have been linked to neurologic diseases, such as Parkinson's. Common belief has held that iron accumulation happens as a result of the aging process.

17 Jan 2015

Abnormal attachment of sugar to BACE1 enzyme leads to formation of Aβ plaques in the brain

Researchers at the RIKEN-Max Planck Joint Research Center in Japan have demonstrated that hallmark symptoms of Alzheimer's disease can be reduced when sugars are prevented from binding to one of the key enzymes implicated in the disease. The new findings, reported in EMBO Molecular Medicine, show that abnormal attachment of a particular sugar to the enzyme BACE1 is a critical factor leading to the formation of Aβ plaques in the brain, and that plaques were reduced and cognitive performance improved when this action was prevented in mice through loss of the enzyme GnT-III.

17 Jan 2015

Study: Stem cells derived from human female amnion have anti-inflammatory effects

Stem cells derived from human amnion have for some time been considered promising for cell therapies because of their ease of access, ability to differentiate, and absence of ethical issues.

17 Jan 2015

Researchers gain new insight into fragile X syndrome

Scientists have gained new insight into fragile X syndrome -- the most common cause of inherited intellectual disability -- by studying the case of a person without the disorder, but with two of its classic symptoms.

17 Jan 2015

Concentric remodelling preserves right ventricular function in PAH

Systolic function is better preserved in patients with idiopathic pulmonary arterial hypertension if they have a higher right ventricle mass-to-volume ratio, research shows.

16 Jan 2015

Peripheral muscles weakened in PAH patients

Patients with pulmonary arterial hypertension have peripheral muscle weakness that is independent of impairments in their respiratory muscles, research shows.

16 Jan 2015

CT measures can refine PAH prognosis

Structural features identifiable on computed tomography pulmonary angiography can provide prognostic information for patients with pulmonary arterial hypertension, say UK researchers.

16 Jan 2015

Unmet medication need in neuropathic pain

A systematic review and meta-analysis reveals that current treatments for neuropathic pain achieve only a moderate response in patients.

16 Jan 2015

Nonmotor symptoms cluster in Parkinson’s disease patients

Nonmotor symptoms tend to appear in specific clusters in patients with Parkinson’s disease and often predate the onset of motor symptoms, research shows.

16 Jan 2015

Disturbed gut microbiome linked to Parkinson’s disease

Research suggests that the intestinal microbiome may be altered in patients with Parkinson’s disease, with some alterations being specific to the motor subtype.

16 Jan 2015

Researchers reveal how melanoma becomes resistant to promising new drug combo therapy

In a new study led by UCLA Jonsson Comprehensive Cancer Center member Dr. Roger Lo, researchers have uncovered how melanoma becomes resistant to a promising new drug combo therapy utilizing BRAF+MEK inhibitors in patients after an initial period of tumor shrinkage.

16 Jan 2015

JHU Applied Physics Laboratory awarded $4 million to develop retinal prosthesis system

The Johns Hopkins University Applied Physics Laboratory, in Laurel, Maryland, has received $4 million in funding from the Mann Fund to develop a next-generation retinal prosthesis system. The Mann Fund was created by philanthropist Alfred E. Mann 15 years ago to support the development of biomedical technologies.

16 Jan 2015

CUMC researchers identify that OCR stem cells can regenerate bone and cartilage in mice

A stem cell capable of regenerating both bone and cartilage has been identified in bone marrow of mice. The discovery by researchers at Columbia University Medical Center is reported today in the online issue of the journal Cell.

16 Jan 2015

Researchers uncover new gene tied to incurable eye disorder

An exhaustive hereditary analysis of a large Louisiana family with vision issues has uncovered a new gene tied to an incurable eye disorder called retinitis pigmentosa, according to an examination led by scientists at The University of Texas Health Science Center at Houston.

16 Jan 2015

New study demonstrates that vitamin D can protect people against colorectal cancer

A new study by Dana-Farber Cancer Institute investigators demonstrates that vitamin D can protect some people with colorectal cancer by perking up the immune system's vigilance against tumor cells.

16 Jan 2015

Increase in Lassa fever cases could be due to human-to-human transmission, research reveals

One in five cases of Lassa fever - a disease that kills around 5,000 people a year in West Africa - could be due to human-to-human transmission, with a large proportion of these cases caused by 'super-spreaders', according to research published today in the journal PLOS Neglected Tropical Diseases.

16 Jan 2015

New research helps explain why pancreatic cancer is so lethal

New research from the University of Michigan Comprehensive Cancer Center helps explain why pancreatic cancer is so lethal, with fewer than a third of patients surviving even early stage disease.

16 Jan 2015

New study characterizes genetic underpinnings of phyllodes tumors

A new study from researchers at the University of Michigan Comprehensive Cancer Center characterizes the genetic underpinnings of a rare type of breast tumor called phyllodes tumors, offering the first comprehensive analysis of the molecular alterations at work in these tumors.

16 Jan 2015

Women with postpartum depression during pregnancy may face greater risk, study finds

When it comes to postpartum depression, one size does not fit all, according to a new study led by University of North Carolina School of Medicine researchers.

16 Jan 2015

John H. Postlethwait selected to receive GSA's George W. Beadle Award

The Genetics Society of America is pleased to announce that John H. Postlethwait, PhD (University of Oregon) has been selected to receive the Society's George W. Beadle Award for outstanding contributions to the community of genetics researchers.

16 Jan 2015

Medical Research News

Iron accumulation in human tissues may contribute to the aging process

Abnormal attachment of sugar to BACE1 enzyme leads to formation of Aβ plaques in the brain

Study: Stem cells derived from human female amnion have anti-inflammatory effects

Researchers gain new insight into fragile X syndrome

Concentric remodelling preserves right ventricular function in PAH

Peripheral muscles weakened in PAH patients

CT measures can refine PAH prognosis

Unmet medication need in neuropathic pain

Nonmotor symptoms cluster in Parkinson’s disease patients

Disturbed gut microbiome linked to Parkinson’s disease

Researchers reveal how melanoma becomes resistant to promising new drug combo therapy

JHU Applied Physics Laboratory awarded $4 million to develop retinal prosthesis system

CUMC researchers identify that OCR stem cells can regenerate bone and cartilage in mice

Researchers uncover new gene tied to incurable eye disorder

New study demonstrates that vitamin D can protect people against colorectal cancer

Increase in Lassa fever cases could be due to human-to-human transmission, research reveals

New research helps explain why pancreatic cancer is so lethal

New study characterizes genetic underpinnings of phyllodes tumors

Women with postpartum depression during pregnancy may face greater risk, study finds

John H. Postlethwait selected to receive GSA's George W. Beadle Award

Decoding Cannabis: Differentiating Hemp and Marijuana

Deciphering the Microbiome with The Microsetta Initiative

Leveraging the power of automation to boost research

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