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UCMR researchers discover compounds that can attenuate virulence of Listeria monocytogenes

Scientists at Umea Centre for Microbial Research have discovered chemical compounds which are able to attenuate the virulence of the bacterial human pathogen Listeria monocytogenes. Their findings are published today in the high impact journal Cell Chemical Biology.

19 Mar 2016

Novel plasmid-based microRNA inhibitor system effectively prevents microRNA activity in cells

Today at the 45th Annual Meeting & Exhibition of the American Association for Dental Research, researcher Brad Amendt, University of Iowa, Iowa City, USA, will present a study titled "New Biotechnology to Inhibit MicroRNA Activity and Novel Applications for Craniofacial and Dental Research."

19 Mar 2016

Antibiotic treatment for mild appendicitis does not increase risk for complications

Using antibiotics as the primary treatment for mild appendicitis does not increase the risk for complications at least in the first year. But other considerations must also be taken into account, say researchers.

19 Mar 2016

Rare ADCY9 mutations linked to non-syndromic oral clefts in Puerto Ricans

Today at the 45th Annual Meeting & Exhibition of the American Association for Dental Research, researcher Carmen Buxó-Martínez, University of Puerto Rico, San Juan, will present a study titled "Identification of Rare ADCY9 Mutations and Non-syndromic Oral Clefts in Puerto Ricans." The AADR Annual Meeting is being held in conjunction with the 40th Annual Meeting of the Canadian Association for Dental Research.

19 Mar 2016

Study associates prevalence of homosexual relations in Uganda with increased health risks

The results are based on a survey with nearly 3,000 participating students in south-western Uganda. The students responded to a number of questions, including aspects concerning sexuality, physical and mental health, sexual risk behaviour, and experiences with drugs. The questions about homosexuality pertained to the students' emotions as well as their actions.

19 Mar 2016

Patients with schizophrenia demonstrate specific leftward asymmetry for globus pallidus volume

A Japanese research group found that patients with schizophrenia demonstrated a specific leftward volumetric asymmetry for the globus pallidus, one of the basal ganglia of the brain. The basal ganglia are involved in motivation and volition, the impairment of which may result in difficulties in social life. This finding is expected to help elucidate the underlying pathological mechanisms of schizophrenia. Moreover, it will be a step toward the development of therapeutic strategies for schizophrenia.

19 Mar 2016

Gay, bisexual, lesbian Canadians experience high levels of mood and anxiety disorders

Gay, lesbian and bisexual Canadians experience more mood and anxiety disorders than other Canadians, and they are more likely to turn to heavy drinking.

19 Mar 2016

Manipulation of NAD could lead to potential therapy for acute kidney injury

Approximately one out of five hospitalized adults and one out of three hospitalized children worldwide experience acute kidney injury, the sudden loss of kidney function. Many different factors, including surgery, chemotherapy or shock, can lead to acute kidney injury, but exactly why the kidneys are so vulnerable to these and other stressors has not been well understood.

19 Mar 2016

Study links severe early childhood caries to microbiome among Canadian First Nations children

Today at the 45th Annual Meeting & Exhibition of the American Association for Dental Research, researcher Robert Schroth, University of Manitoba, Children's Hospital Research Institute of Manitoba, Winnipeg, Canada, will present a study titled "Microbiome Associated With Severe Caries in Canadian First Nations Children." The AADR Annual Meeting is being held in conjunction with the 40th Annual Meeting of the Canadian Association for Dental Research.

19 Mar 2016

VeggiEAT project aims to promote healthy eating, encourage more vegetable consumption

A collaborative team from Bournemouth University, led by nutrition expert Professor Heather Hartwell, are hoping to change our eating habits, championing vegetable consumption through a Europe-wide research project called VeggiEAT.

19 Mar 2016

Neutralizing acidic tumor environment increases efficacy of immune-targeting cancer therapies

Cancer cells have the ability to grow in an acidic tumor environment that is detrimental to other cells, including immune cells. In a Cancer Research cover article published this week, Moffitt Cancer Center reported that neutralizing the acidic tumor environment increases the efficacy of several immune-targeting cancer therapies.

19 Mar 2016

Value of PD-L1 testing in NSCLC debated

Two viewpoint articles published in JAMA Oncology provide opposing opinions on the benefit of testing for programmed death-ligand 1 expression in patients with non-small-cell lung cancer treated with checkpoint inhibitors.

18 Mar 2016

Transcranial direct current stimulation assists chronic stroke rehabilitation

Adding ipsilesional anodal transcranial direct current stimulation to upper limb rehabilitation delivers motor improvements in chronic stroke patients that last for at least 3 months, a randomised trial shows.

18 Mar 2016

Newly developed computer models can simulate stem cell transplant recovery

Scientists at Virginia Commonwealth University have developed computer models that can simulate the recovery of the immune system in patients undergoing stem cell transplants.

18 Mar 2016

Paracetamol does not meet minimum standard of clinical effectiveness in osteoarthritis patients

In a large-scale analysis of pain-relief medication for osteoarthritis, researchers found that paracetamol does not meet the minimum standard of clinical effectiveness in reducing pain or improving physical function in patients with knee and hip osteoarthritis.

18 Mar 2016

Chronic pain patients can reduce emotional response to pain through spinal cord stimulation

Researchers at The Ohio State University Wexner Medical Center have shown that patients who have chronic pain can reduce their emotional response to the pain through spinal cord stimulation.

18 Mar 2016

Stem cell therapy restores normal bone structure in mice with age-related osteoporosis

Imagine telling a patient suffering from age-related (type-II) osteoporosis that a single injection of stem cells could restore their normal bone structure. This week, with a publication in STEM CELLS Translational Medicine, a group of researchers from the University of Toronto and The Ottawa Hospital suggest that this scenario may not be too far away.

18 Mar 2016

Brain's immune cells play direct role in development of amyotrophic lateral sclerosis

Cedars-Sinai research scientists have found that immune cells in the brain play a direct role in the development of amyotrophic lateral sclerosis, or ALS, offering hope for new therapies to target the neurodegenerative disease that gradually leads to paralysis and death.

18 Mar 2016

Intervention programme significantly decreases preschool children's disruptive behaviour

Training parents online and over the telephone significantly decreased preschool children's disruptive behaviour, shows the new Strongest Families study from the Research Centre for Child Psychiatry at the University of Turku.

18 Mar 2016

Family-linked treatment may benefit children with cardiomyopathy-related chronic heart disease

A newly published national study by the Children's Hospital of Michigan and Wayne State University School of Medicine researchers shows that "parental impact and family functioning" become increasingly abnormal when children with cardiomyopathy-related chronic heart disease are more severely ill than children less affected by the disease.

18 Mar 2016

Medical Research News

UCMR researchers discover compounds that can attenuate virulence of Listeria monocytogenes

Novel plasmid-based microRNA inhibitor system effectively prevents microRNA activity in cells

Antibiotic treatment for mild appendicitis does not increase risk for complications

Rare ADCY9 mutations linked to non-syndromic oral clefts in Puerto Ricans

Study associates prevalence of homosexual relations in Uganda with increased health risks

Patients with schizophrenia demonstrate specific leftward asymmetry for globus pallidus volume

Gay, bisexual, lesbian Canadians experience high levels of mood and anxiety disorders

Manipulation of NAD could lead to potential therapy for acute kidney injury

Study links severe early childhood caries to microbiome among Canadian First Nations children

VeggiEAT project aims to promote healthy eating, encourage more vegetable consumption

Neutralizing acidic tumor environment increases efficacy of immune-targeting cancer therapies

Value of PD-L1 testing in NSCLC debated

Transcranial direct current stimulation assists chronic stroke rehabilitation

Newly developed computer models can simulate stem cell transplant recovery

Paracetamol does not meet minimum standard of clinical effectiveness in osteoarthritis patients

Chronic pain patients can reduce emotional response to pain through spinal cord stimulation

Stem cell therapy restores normal bone structure in mice with age-related osteoporosis

Brain's immune cells play direct role in development of amyotrophic lateral sclerosis

Intervention programme significantly decreases preschool children's disruptive behaviour

Family-linked treatment may benefit children with cardiomyopathy-related chronic heart disease

Advancing brain microphysiological systems (bMPS)

PhD researcher at LifeArc

Unveiling Hidden Potential: Organoids for Disease Modeling in Neuroscience Research

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