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Mechanistic subtypes of IPAH revealed

Researchers have provided evidence for distinct processes underlying vasodilator-responsive and nonresponsive idiopathic pulmonary arterial hypertension.

13 Feb 2015

$Scleral imbrication shows promise in second surgery for refractory MHRD$

Scleral imbrication shows promise in second surgery for refractory MHRD

Combining vitrectomy and gas tamponade with sclera imbrication results in high retinal reattachment and macular hole closure rates among patients with refractory macular hole retinal detachment associated with high myopia, study findings indicate.

13 Feb 2015

Omega-3 could supplement anti-VEGF treatment in AMD

Pilot study findings suggest that taking omega-3 fatty acid supplements could increase the efficacy or reduce the needed frequency of anti-vascular endothelial growth factor treatment in patients with exudative age-related macular degeneration.

13 Feb 2015

Choroidal thickness reduced in diabetic macular oedema patients

Patients with diabetic macular oedema have smaller choroidal thickness measurements in affected and unaffected eyes compared with healthy individuals, spectral-domain optical coherence tomography imaging results reveal.

13 Feb 2015

Retinal venular calibre predicts ranibizumab vision improvement

Retinal venular calibre may predict visual outcome in diabetic macular oedema patients given the anti-vascular endothelial growth factor monoclonal antibody ranibizumab, a pilot study suggests.

13 Feb 2015

Retinal function affected early in Type 1, 2 diabetes

Visual dysfunction manifests early in Type 1 and Type 2 diabetes, research shows, with functional impairment detected in patients with nonproliferative diabetic retinopathy lacking clinical signs and symptoms of diabetic macular oedema.

13 Feb 2015

Adaptive optics find reflectivity differences between drusen types in AMD

Adaptive optics provide insight into the differences in reflectivity between medium–large drusen and reticular pseudodrusen in patients with age-related macular degeneration, researchers report.

13 Feb 2015

Meta-analysis gives intravitreal ranibizumab vascular adverse risk profile

Intravitreal ranibizumab treatment for age-related macular degeneration does not elevate the risk of mortality, suggests a meta-analysis published in Ophthalmology.

13 Feb 2015

VEGF inhibition does not regulate collateral vessels in retinal vein occlusion

The formation of collateral vessels does not appear to improve visual acuity in patients with branch or central retinal vein occlusion, and is unaffected by anti-vascular endothelial growth factor therapy, a retrospective analysis suggests.

13 Feb 2015

‘Earliest’ characteristics presaging drusen-associated atrophy identified

Researchers have used spectral-domain optical coherence tomography to identify specific pathological changes that precede the development of drusen-associated atrophy in patients with age-related macular degeneration.

13 Feb 2015

Creatine monohydrate disappoints in Parkinson’s disease

Creatine monohydrate fails to live up to its early promise in patients with Parkinson’s disease, show the results of the Long-term Study 1.

13 Feb 2015

Novel image-analysis technique improves breast cancer detection and diagnosis

Researchers at the University of Oklahoma have developed an image-analysis technique that is designed to improve breast cancer detection and diagnosis.

13 Feb 2015

Declarative memory helps individuals with neurodevelopmental disorders compensate for dysfunction

Individuals with five neurodevelopmental disorders -- autism spectrum disorder, obsessive-compulsive disorder, Tourette syndrome, dyslexia, and Specific Language Impairment -- appear to compensate for dysfunction by relying on a single powerful and nimble system in the brain known as declarative memory.

13 Feb 2015

Immune system exploits flu virus' dependence on host's machinery

Viruses are masters of outsourcing, entrusting their fundamental function - reproduction - to the host cells they infect. But it turns out this highly economical approach also creates vulnerability.

13 Feb 2015

Lenvatinib trial offers hope for thyroid cancer patients

A new targeted therapy called lenvatinib has been shown to improve progression-free survival among patients with advanced thyroid cancer that is not responsive to iodine-131.

13 Feb 2015

Imperial College London to invest in new facility at Babraham Campus to support dynamic bioscience companies

Imperial College London is to invest in a new facility at the Babraham Research Campus in Cambridge to support spin-out and scale-up companies, and maximise the impact of research from universities.

From Abzena 13 Feb 2015

AXT adds TriFoil imaging products to their preclinical imaging portfolio

TriFoils flagship is the Triumph tri-modal imaging system that incorporates PET/SPECT and CT technologies all in a single instrument. It has a bore size of 15cm and an axial view of 30cm making ideal for small animal studies.

From MR Solutions 13 Feb 2015

Amedica Submits 510(k) Application to FDA for Composite Spinal Interbody Spacers with Porous Silicon Nitride Center

Amedica announced today that it has filed a submission for 510(k) clearance of the Valeo C Interbody with CsC Osteo-Conductive Scaffolding (“Valeo CCsC”) with the U.S. Food and Drug Administration (“FDA”) relating to its composite silicon nitride spinal interbody devices.

13 Feb 2015

'Mad Cow' discovery points to possible neuron killing mechanism behind alzheimer’s and parkinson’s diseases

The new study, published recently in the journal Brain, revealed the mechanism of toxicity of a misfolded form of the protein that underlies prion diseases, such as bovine spongiform encephalopathy (“mad cow disease”) and its human equivalent, Creutzfeldt-Jakob disease.

13 Feb 2015

Clinical trial proves ‘inside the artery’ therapy improves patient outcomes after stroke

"This clinical trial proves beyond any doubt that inside the artery therapy is the best possible treatment for patients suffering an acute ischemic stroke from a large artery occlusion," according to Donald Frei, MD, Neuro Interventional Surgeon at Swedish Medical Center and Radiology Imaging Associates in Englewood, CO.

13 Feb 2015