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Sacral neuromodulation augments efficacy of antimuscarinics in OAB

The addition of sacral neuromodulation to antimuscarinic pharmacotherapy offers significant benefits over antimuscarinics alone in the treatment of women with idiopathic overactive bladder, study findings show.

17 Sep 2014

Fat mass contributes to musculoskeletal pain risk

People with high fat mass could be at an increased risk of musculoskeletal pain, say researchers.

17 Sep 2014

Catecholamine polymorphism influences opioid use

The catechol-O-methyltransferase rs4680 single nucleotide polymorphism could affect postoperative opioid consumption, study findings show.

17 Sep 2014

S. pneumoniae drug susceptibility tracked in Japan

A 12-year survey of the antimicrobial susceptibility of Streptococcus pneumoniae isolates in Miyagi Prefecture in Japan has identified important changes, including improved susceptibility to β-lactam antibiotics.

17 Sep 2014

S-1 plus radiotherapy shows promise in elderly NSCLC patients

Concurrent administration of S-1 chemotherapy and radiotherapy has a favourable impact on survival in elderly patients with locally advanced non-small-cell lung cancer, a phase II trial has found.

17 Sep 2014

Age confounds relationship between ambulatory and office BP

The relationship between ambulatory and office blood pressure varies with age, with the likelihood of white-coat hypertension increasing as people get older, a study shows.

17 Sep 2014

Lobectomy and segmentectomy have similar efficacy in stage I NSCLC

Lobectomy and anatomic segmentectomy appear to offer similar perioperative and oncological outcomes in patients with stage I non-small-cell lung cancer, analysis suggests.

17 Sep 2014

Life events may worsen bipolar I disorder course

A study suggests that negative life events may trigger depressive episodes in patients with bipolar I disorder.

17 Sep 2014

Reading deficits in schizophrenia contribute to underachievement

People with schizophrenia display severe deficits in reading ability that are not captured in current routine clinical assessments, a study by US researchers indicates.

17 Sep 2014

Childhood psychiatric disorders linked to schizophrenia risk

Having a childhood psychiatric disorder increases people’s likelihood of being later diagnosed with schizophrenia, research shows.

17 Sep 2014

Cyclothymic temperament linked to suicidality

The presence of a cyclothymic temperament in inpatients with bipolar disorder may indicate a high likelihood of hopelessness and suicidality, report researchers.

17 Sep 2014

‘Reassuring’ findings on microvascular risk in diabetic statin users

Statin treatment prior to diabetes onset does not appear to increase the risk of microvascular disease and may even be protective against some forms, findings from a registry study suggest.

17 Sep 2014

ICO-IDIBELL researchers identify 5 genes differentially expressed in colorectal tumors

Researchers at the Catalan Institute of Oncology-Bellvitge Biomedical Research Institute, led by David Garcia-Mollev- have identified 5 genes differentially expressed in normal accompanying cells in colorectal tumors.

17 Sep 2014

Study links slowed processing speed with executive deficits in individuals with multiple sclerosis

Kessler Foundation researchers have published a study supporting the role of slowed processing speed in the executive deficits found in individuals with multiple sclerosis (MS).

17 Sep 2014

APOC3 gene variant dramatically reduces triglyceride levels in the blood

Research using data collected from around 4,000 healthy people in the UK has enabled scientists to identify a rare genetic variant that dramatically reduces levels of certain types of lipids in the blood. The study is the first to emerge from the UK10K Project's cohort of samples from the general public and demonstrates the power of whole genome sequencing at scale.

17 Sep 2014

Current smokers at increased risk of developing SPLC

Non-small cell lung cancer (NSCLC) survivors who never smoked or who are former smokers at the time of diagnosis have a lower risk of developing secondary primary lung cancers (SPLC) compared to those who are current smokers, suggesting that increased tobacco exposure is associated with a higher risk of SPLC, according to research presented today at the American Society for Radiation Oncology's 56th Annual Meeting.

17 Sep 2014

Parous women have higher chance of developing estrogen receptor-negative breast cancer

Women who have had children (parous women) appear to have an increased risk of developing estrogen receptor-negative breast cancer, the subtype that carries a higher mortality rate and is more common in women of African ancestry.

17 Sep 2014

Researchers gain new knowledge about complex processes that cause Parkinson's disease

Using advanced computer models, neuroscience researchers at the University of Copenhagen have gained new knowledge about the complex processes that cause Parkinson's disease. The findings have recently been published in the prestigious Journal of Neuroscience.

17 Sep 2014

UMass Amherst doctoral student in chemistry receives USP's 2014-15 Global Fellowship Award

University of Massachusetts Amherst doctoral student in chemistry Khaja Muneeruddin is one of three promising young scientists to recently receive the 2014-15 Global Fellowship Award from the United States Pharmacopeial Convention, dual publishers of the official pharmacopeia and National Formulary (NF), the book of directions for identifying compound medicines.

17 Sep 2014

LABA-ICS combination therapy better than LABAs alone for COPD

Among older adults with chronic obstructive pulmonary disease (COPD), particularly those with asthma, newly prescribed long-acting beta-agonists (LABAs) and inhaled corticosteroid combination therapy, compared with newly prescribed LABAs alone, was associated with a lower risk of death or COPD hospitalization, according to a study in the September 17 issue of JAMA.

17 Sep 2014