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Prognostic value of visceral plural invasion limited in part-solid lung cancer

Visceral plural invasion is a significant predictor of survival in patients with small solid lung tumours but not in patients with part-solid tumours, Japanese study findings indicate.

23 Jul 2014

Combined risk score enhances radiation pneumonitis prediction

Combining dose-volume histogram parameters with age and baseline pulmonary fibrosis score creates a novel predictive risk score that improves prediction of radiation pneumonitis in patients receiving concurrent chemoradiotherapy for non-small-cell lung cancer, research shows.

23 Jul 2014

Standard TFI definition still applies for relapsed SCLC classification

Italian researchers have confirmed that using a treatment-free interval cut-off of 60 days to classify relapsed small-cell lung cancer as sensitive or resistant can be regarded as the standard definition.

23 Jul 2014

Co-targeting strategies suggested for EGFR-TKI resistance in NSCLC

Researchers have identified additional resistance mechanisms that could be targeted to improve the efficacy of irreversible epidermal growth factor receptor-tyrosine kinase inhibitors in patients with non-small-cell lung cancer harbouring both EGFR and T790M mutations.

23 Jul 2014

CRIPTO1 role in TKI resistance elucidated

Overexpression of CRIPTO1 may explain intrinsic tyrosine kinase inhibitor resistance in around 10% of patients with non-small-cell lung cancer and endothelial growth factor receptor mutations, research indicates.

23 Jul 2014

Collaboration classification useful for Japanese lung cancer patients

Epidermal growth factor receptor status and prognosis in Japanese patients can be predicted by a recently developed lung adenocarcinoma classification system, say researchers.

23 Jul 2014

More genetic suspects for schizophrenia brought to light

A meta-analysis from the Schizophrenia Working Group of the Psychiatric Genomics Consortium has revealed a large number of previously unreported genetic loci that may have a role in schizophrenia.

23 Jul 2014

Impulse control predicts euthymia in bipolar disorder

Patients with bipolar disorder who have good trait impulse control are likely to respond better to treatment than those with poor impulse control, say researchers.

23 Jul 2014

Blood flow to the brain significantly affected by dehydration

It’s a lesson riders in the Tour de France know all too well – drinking water while cycling in extreme heat is vital if they are to remain at peak performance.

23 Jul 2014

Pixcelldata announces new partnership with Basys Data

Pixcelldata, the innovative Irish developer of Collibio digital pathology management and collaboration software has announced a partnership with Basys Data, the provider of PathoWin+ LIMS software to pathology laboratories in Switzerland.

23 Jul 2014

Tulane University psychiatrist to study how parental bond with children leaves lasting genetic protection

Tulane University psychiatrist Dr. Stacy Drury has been given $2.4 million by the National Institutes of Health to test a provocative new theory - how well children bond with a parent in the first year of life leaves lasting genetic protection, potentially shielding them from disease risks well into adulthood.

23 Jul 2014

Severe pain during and post delivery linked to postpartum depression

Controlling pain during childbirth and post delivery may reduce the risk of postpartum depression, writes Katherine Wisner, M.D., a Northwestern Medicine- perinatal psychiatrist, in a July 23 editorial in Anesthesia & Analgesia.

23 Jul 2014

Astrocytes may be behind mental disorders, new research reveals

Astrocytes, the cells that make the background of the brain and support neurons, might be behind mental disorders such as depression and schizophrenia, according to new research by a Portuguese team from the ICVS at the University of Minho.

23 Jul 2014

University of Leicester receives funding from two Masonic charities for heart study

A University of Leicester research project has received vital philanthropic funding for the second year from two Masonic charities.

23 Jul 2014

Cedars-Sinai investigators developing novel treatment for locally advanced pancreatic cancer

Investigators at the Cedars-Sinai Samuel Oschin Comprehensive Cancer Institute are developing a novel, multistep investigational treatment for one of the most complex and difficult-to-treat forms of the disease, locally advanced pancreatic cancer.

23 Jul 2014

Autoimmune diseases share certain pathogenic mechanisms with cancer

Autoimmune disorders may share certain pathogenic mechanisms with cancer, according to a new report by George Washington University researcher Linda Kusner, Ph.D., published in PLOS ONE on July 22.

23 Jul 2014

Iowa researchers develop vaccine to combat dust-mite allergies

Researchers at the University of Iowa have developed a vaccine that can combat dust-mite allergies by naturally switching the body's immune response.

23 Jul 2014

Study: Lack of trust in one's physician affects physical, mental well-being of cancer patients

The physical and mental well-being of people with cancer may be affected by how they feel about their relationship with their physician and by differences in attachment styles (how they rely and depend on others), finds a new study from General Hospital Psychiatry.

23 Jul 2014

Vanderbilt-led research team identifies protein "signatures" that drive colorectal cancer

A Vanderbilt University-led research team has identified protein "signatures" of genetic mutations that drive colorectal cancer, the nation's second leading cause of cancer deaths after lung cancer.

23 Jul 2014

Pilot study shows that anti-cancer drug can activate hidden HIV

A pilot study by HIV researchers from Aarhus University and Aarhus University Hospital in Denmark has shown that an anti-cancer drug can activate hidden HIV.

23 Jul 2014