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Dysregulation of epigenetic marks may play role in chronic kidney disease, shows study

The research of physician-scientist Katalin Susztak, MD, PhD, associate professor of Medicine in the Renal Electrolyte and Hypertension Division, at the Perelman School of Medicine, University of Pennsylvania, strives to understand the molecular roots and genetic predisposition of chronic kidney disease.

26 Nov 2013

Cocktail eradicates animals' brain tumors

A novel immune-boosting drug combination eradicates brain cancer in mice, according to a study in The Journal of Experimental Medicine.

26 Nov 2013

Chicken eggs can provide better understanding of human birth defects

Clemson University researchers found that chicken eggs can provide a better understanding of human birth defects. Susan Chapman, associate professor in Clemson's College of Agriculture, Forestry and Life Sciences, received a South Carolina IDeA Networks of Biomedical Research Excellence award that allowed researchers to identify two regions in the chicken genome that are associated with congenital deafness and spine deformities in humans.

26 Nov 2013

Exposure of fetus to maternal mood disorders may lead to behavioral problems in offspring

A great number of women experience depression or anxiety while pregnant, and exposure of the fetus to these maternal mood disorders may lead to long-term emotional and behavioral problems in the offspring.

26 Nov 2013

Research: Higher BMI liked with increased risk of hearing loss in women

According to the World Health Organization, 360 million people have disabling hearing loss, a condition that is often considered to be an unavoidable side effect of aging.

26 Nov 2013

Sacral neuromodulation stands test of time in LUTD

Follow-up of patients at a Belgian institution reveals that sacral neuromodulation is effective for the treatment of lower urinary tract dysfunction over the long term, but often requires reintervention.

From Medtronic 25 Nov 2013

First symptom predicts urodynamic diagnosis in MUI

Researchers have found that the first or most bothersome symptom in women with mixed urinary incontinence closely relates to the urodynamic diagnosis.

25 Nov 2013

Novel urinary antigen test boosts S. pneumoniae CAP detection

Research published in the European Respiratory Journal shows that addition of a serotype-specific urinary antigen detection test to existing diagnostic methods can increase the detection of Streptococcus pneumoniae community-acquired pneumonia by over a third.

25 Nov 2013

New diabetes has little impact on outcomes in elderly hypertensives

Established, but not newly diagnosed, diabetes is associated with reduced survival among elderly patients with hypertension, shows an analysis of the ANBP2 study.

25 Nov 2013

Nonmotor symptoms may underlie Parkinson’s sleep complaints

In people with Parkinson’s disease, symptoms and comorbidities associated with insomnia differ from those associated with daytime sleepiness, US researchers report.

25 Nov 2013

Anti-epileptic drugs, bone loss and supplements

Antiepileptic drugs are medications used to prevent and control seizure disorders. These medications are also frequently used for other diagnoses other than seizures, however this current study concentrated on patients with a seizure disorder.

25 Nov 2013

Researchers show for first time how influenza A viruses infect respiratory cells

Researchers at the University of California, San Diego School of Medicine have shown for the first time how influenza A viruses snip through a protective mucus net to both infect respiratory cells and later cut their way out to infect other cells.

25 Nov 2013

PCBs banned by the US 3 decades ago hurt seniors' cognitive performance

Although PCBs have been banned in the United States since 1979, University of Montreal and CHU Sainte-Justine researcher Maryse Bouchard has found that higher levels of the toxin was associated with lower cognitive performance in seniors.

25 Nov 2013

Researchers identify potential therapeutic target in treatment of certain AML

Acute myeloid leukemia (AML) is a group of heterogeneous diseases with considerable diversity in terms of genetic abnormalities. Mutations of CEBPA, a tumour suppressor, are found in about 10 per cent of human AML patients. In two separate studies on CEBPA mutations in AML subtypes, researchers successfully identified and validated a gene known as Sox4 as a potential therapeutic target and a class of anti-cancer drugs, histone deacetylase (HDAC) inhibitors, as potential candidates in the treatment of certain AML.

25 Nov 2013

Waseda University researchers observe molecular motors that play critical role in chromosome transport

Researchers at Waseda University in Japan have for the first time directly observed the “molecular motor”, called Xkid, that plays a critical role in facilitating the proper alignment of chromosomes during cell division. Their findings are expected to contribute greatly to elucidating the molecular mechanisms of chromosome segregation, a key aspect of the development of certain medical disorders including cancer and birth defects.

25 Nov 2013

People with food allergy more likely to be murdered than to die from severe reaction

A person with a food allergy is more likely to be murdered than to die from a severe reaction, according to a new study.

25 Nov 2013

UV radiation: A central factor behind Queensland’s record rates of Merkel cell carcinoma

Queensland has at least double the rates of the world’s deadliest skin cancer on record – yet much of the state are unaware the rare cancer even exists.

25 Nov 2013

Scientists create artificial skin from stem cells of umbilical cord

Spanish scientists, from the Tissue Engineering Research Group, from the Dept. of Histology at the University of Granada, have managed, for the first time, to grow artificial skin from stem cells of umbilical cord.

25 Nov 2013

BMI or measure of obesity does not play significant role in weight loss operation, says study

A new study investigating why obese patients choose one type of weight loss operation over another reveals that the main factors influencing decision making are whether patients have type 2 diabetes, how much weight they want to lose, and their tolerance for surgical risk to achieve their ideal weight.

25 Nov 2013

Research: Notch protein plays essential role in triggering T-cell development

The lab of Avinash Bhandoola, PhD, professor of Pathology and Laboratory Medicine, has studied the origins of T cells for many years. One protein called Notch, which has well-known roles in the development of multiple tissues, plays an essential role in triggering T-cell development.

25 Nov 2013