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3D image of cell signaling molecules indicates a trippable power switch

A three-dimensional image of one of the proteins that serves as an on-off switch as it binds to receptors on the surface of a cell suggests there may be a sort of main power switch that could be tripped. These surface receptors are responsible for helping cells discern light, set the heart racing, or detect pain.

22 Apr 2013

Combination of diet and exercise produces better results

A worrisome increase in obesity levels in much of the world suggests that current methods of motivating people to eat healthier food and get more exercise are not all that successful. Much of today's research focuses on ways of delivering messages in order to obtain the best sustained adherence to these two key health behaviors.

22 Apr 2013

Study identifies potential drug targets that interfere with cancer metabolism

A massive study analyzing gene expression data from 22 tumor types has identified multiple metabolic expression changes associated with cancer.

22 Apr 2013

Genetic study defines link between primary sclerosing cholangitis and other autoimmune diseases

Researchers have newly associated nine genetic regions with a rare autoimmune disease of the liver known as primary sclerosing cholangitis (PSC). This brings the total number of genetic regions associated with the disease to 16.

22 Apr 2013

Researchers decipher the underlying mechanism of antiviral drug

A long-forgotten candidate for antiviral therapy is undergoing a renaissance: Since the 1970s, the small molecule CMA has been considered a potent agent against viral infections, yet it was never approved for clinical use.

22 Apr 2013

Study: Use of anti-TNF therapies in RA patients does not increase risk of herpes zoster

Patients with rheumatoid arthritis (RA) who initiated use of anti-tumor necrosis factor therapies were not at a higher risk of developing herpes zoster (shingles), compared with patients who initiated nonbiologic treatment regimens, according to research from the University of Alabama at Birmingham (UAB) and the Oregon Health and Science University. The findings appeared in the March 6, 2013, issue of the Journal of the American Medical Association (JAMA).

22 Apr 2013

Potential therapies for smell loss

Snot. It's not something most of us spend a lot of time thinking about, but, for a team of researchers in Washington, D.C., it's front and center.

22 Apr 2013

Study examines link between cognitive complaints and neuropsychological testing abnormalities in breast cancer patients

For many years, breast cancer patients have reported experiencing difficulties with memory, concentration and other cognitive functions following cancer treatment. Whether this mental "fogginess" is psychosomatic or reflects underlying changes in brain function has been a bone of contention among scientists and physicians.

20 Apr 2013

Researchers find new potential target for anti-telomerase cancer therapy

Researchers at UT Southwestern Medical Center have found that alternative splicing - a process that allows a single gene to code for multiple proteins - appears to be a new potential target for anti-telomerase cancer therapy.

20 Apr 2013

Penn Medicine gene therapy study receives Distinguished Clinical Research Achievement Award

A gene therapy study focused on finding a cure for a rare congenital blinding disease has been recognized as one of the ten most outstanding clinical research projects of the year by the Clinical Research Forum.

20 Apr 2013

Shc plays key role in activating and controlling Erk

A protein which is intimately involved in cancer-promoting cell signaling also keeps a key component of the signaling pathway tied down and inactive, a team led by scientists from The University of Texas MD Anderson Cancer Center reports this week in Nature Structural Molecular Biology.

20 Apr 2013

Study identifies seven new genetic regions associated with pulmonary fibrosis

A new genome-wide association study of more than 6,000 people has identified seven new genetic regions associated with pulmonary fibrosis. In findings published online in Nature Genetics on April 14, 2013, researchers at National Jewish Health, the University of Colorado and several other institutions found a number of genes associated with host defense, cell-cell adhesion and DNA repair, which provide clues to possible mechanisms underlying this currently untreatable disease.

20 Apr 2013

Researcher discovers additional mechanical properties of articular cartilage result in osteoarthritis

A researcher at The Feinstein Institute for Medical Research has discovered additional mechanical properties of articular cartilage, a protective cartilage on the ends of bones that wears down over time, resulting in the development of osteoarthritis.

20 Apr 2013

Breast pain more common among women with larger cup sizes

Women with larger cup sizes seem to be more susceptible, but childless women also seem to be more prone, and wearing a sports bra doesn't always help, finds the study, which publishes as London gears up for its annual international marathon tomorrow (Sunday April 21).

20 Apr 2013

Research findings describe specific profile of patients with ACLF

In this prospective study, led by Dr Richard Moreau, INSERM Research Director (Mixed Research Unit 773 "Centre de Recherche biom-dicale Bichat-Beaujon"; INSERM/Universit- Paris Diderot) who is also a practitioner attached to the Hepatology Department of the Beaujon Hospital (AP-HP), researchers studied a cohort of 1343 patients from 12 European countries.

20 Apr 2013

IOF honors Spanish researcher for contributions to clinical research in the field of osteoporosis

The IOF Medal of Achievement has been presented today to Professor Adolfo Diez-Perez, MD, PhD, Head Emeritus of the Department of Internal Medicine, Hospital del Mar, Director of the Bone and Joint Research Unit at the Municipal Institute of Medical Research and Professor of Medicine at the Autonomous University of Barcelona.

20 Apr 2013

Study shows screening breast ultrasound detects more cancers in women with greater breast density

Screening breast ultrasound performed after mammography on women with greater than 50% breast density detects an additional 3.4 cancers or high risk lesions per one thousand woman screened, a detection rate just under that of screening mammography alone for women with less dense breasts, a new study shows.

20 Apr 2013

Clinical Research Forum honors Margaret Gourlay with Top 10 Clinical Research Achievement Award

For leading a study that was the first to define appropriate bone density screening intervals for older women, Margaret Gourlay, MD, MPH, of the University of North Carolina School of Medicine has been honored with a Top 10 Clinical Research Achievement Award from the Clinical Research Forum.

20 Apr 2013

Research shows early access to cognitive behavioural therapy can reduce risk of psychosis

Young people seeking help who are at high risk of developing psychosis could significantly reduce their chances of going on to develop a full-blown psychotic illness by getting early access to cognitive behavioural therapy, new research shows.

From The University of Manchester 19 Apr 2013

Researchers map use of alternative treatment among multiple sclerosis patients

A major Nordic research project involving researchers from the University of Copenhagen has, for the first time ever, mapped the use of alternative treatment among multiple sclerosis patients - knowledge which is important for patients with chronic disease and the way in which society meets them.

19 Apr 2013

Medical Research News

3D image of cell signaling molecules indicates a trippable power switch

Combination of diet and exercise produces better results

Study identifies potential drug targets that interfere with cancer metabolism

Genetic study defines link between primary sclerosing cholangitis and other autoimmune diseases

Researchers decipher the underlying mechanism of antiviral drug

Study: Use of anti-TNF therapies in RA patients does not increase risk of herpes zoster

Potential therapies for smell loss

Study examines link between cognitive complaints and neuropsychological testing abnormalities in breast cancer patients

Researchers find new potential target for anti-telomerase cancer therapy

Penn Medicine gene therapy study receives Distinguished Clinical Research Achievement Award

Shc plays key role in activating and controlling Erk

Study identifies seven new genetic regions associated with pulmonary fibrosis

Researcher discovers additional mechanical properties of articular cartilage result in osteoarthritis

Breast pain more common among women with larger cup sizes

Research findings describe specific profile of patients with ACLF

IOF honors Spanish researcher for contributions to clinical research in the field of osteoporosis

Study shows screening breast ultrasound detects more cancers in women with greater breast density

Clinical Research Forum honors Margaret Gourlay with Top 10 Clinical Research Achievement Award

Research shows early access to cognitive behavioural therapy can reduce risk of psychosis

Researchers map use of alternative treatment among multiple sclerosis patients

Redefining control and consistency in anaerobic microbiome workflows

AI in Healthcare: How generative tools are transforming clinical practice

The future of automation: Machine learning–driven hepatocyte and organoid counting

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