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FT and GGT enzymes can be promising targets for treatment of lung cancer

A research team at the Sahlgrenska Academy at the University of Gothenburg, Sweden, has shown in a study that two closely related enzymes could be targets for the treatment of lung cancer. The discovery was made when the researchers blocked the production of the two enzymes in transgenic mice. This resulted in inhibition of cell growth, fewer tumours and greater survival among the mice.

29 Mar 2010

Addiction to high calorie fat rich food: likened to cocaine and heroin addiction

In a new research our worst fears are confirmed – fatty, fried and fattening foods are addictive. The addiction with these delicious ‘yummies’ may be as potent as that with cocaine or heroin. The study was conducted on experimental animals, rats in this case. When fed with fatty foods in great quantities these rats showed a compulsive need to eat.

29 Mar 2010

Wave of violence and turmoil in Iraq lead to deterioration of linear growth of children

Iraqi children born in areas affected by high levels of violence are shorter in height than children born in less violent areas according to a study at Royal Holloway, University of London.

29 Mar 2010

Bioethical issues and professionalism analyzed through two medical dramas

A medical student and faculty directors from the Johns Hopkins Berman Institute of Bioethics analyzed depictions of bioethical issues and professionalism over a full season of two popular medical dramas-"Grey's Anatomy" and "House, M.D."-and found that the shows were "rife" with ethical dilemmas and actions that often ran afoul of professional codes of conduct.

29 Mar 2010

Child-patient research subjects too often in the dark about their participation: Study

A small study of children with cancer enrolled in therapeutic clinical research trials shows that they don't fully understand what physicians and parents tell them about their participation, nor do they feel they are genuinely involved in the choice to take part.

29 Mar 2010

Minority children in the U.S. face pervasive gap in quality and extent of health care

Minority children in the U.S. face a pervasive gap in the quality and extent of health care received compared to Caucasians, according to a report from the American Academy of Pediatrics written by a UT Southwestern Medical Center physician.

29 Mar 2010

Diagnostic test for alcohol consumption: Measuring protein changes in blood

Measuring a set of protein changes in the blood linked to alcohol use may potentially lead to a more accurate diagnostic test than those currently available, according to Penn State College of Medicine researchers.

29 Mar 2010

Study provides new clues to obesity epidemic

In a newly published study, scientists from The Scripps Research Institute have shown for the first time that the same molecular mechanisms that drive people into drug addiction are behind the compulsion to overeat, pushing people into obesity.

29 Mar 2010

People with diabetes who undergo cancer surgery have greater risk of death: Study

People with diabetes who undergo cancer surgery are more likely to die in the month following their operations than those who have cancer but not diabetes, an analysis by Johns Hopkins researchers suggests.

29 Mar 2010

ER stress response is major driver of insulin resistance, say researchers

Biologists have long known that an enzyme called the PI 3-kinase is a crucial actor in the main molecular pathway for insulin signaling in cells. Researchers at Joslin Diabetes Center now have uncovered startling evidence that one of the proteins in this enzyme also drives a pathway with an opposite result-triggering a stress response that leads to insulin resistance.

29 Mar 2010

TB-causing bacteria can hijack fat metabolism to drive progression of the disease

The factors instrumental in triggering latent tuberculosis infection to progress into active disease have long remained elusive to researchers. New insight into the mystery is provided by Professor David Russell, speaking at the Society for General Microbiology's spring meeting in Edinburgh today. His work could help develop innovative strategies for treating the disease.

29 Mar 2010

New approach may circumvent lost response in insulin due to obesity

Researchers at Children's Hospital Boston have identified a new strategy for treating type 2 diabetes, identifying a cellular pathway that fails when people become obese. By activating this pathway artificially, they were able to normalize blood glucose levels in severely obese and diabetic mice. Their findings will be published online by Nature Medicine on March 28.

29 Mar 2010

UCSF approach may one day be used to create new periods of plasticity in human brain

UCSF scientists report that they were able to prompt a new period of "plasticity," or capacity for change, in the neural circuitry of the visual cortex of juvenile mice. The approach, they say, might some day be used to create new periods of plasticity in the human brain that would allow for the repair of neural circuits following injury or disease.

27 Mar 2010

SAMHSA survey: Underage drinking rates reach more than 27.6% in the past month

More than a quarter of youth aged 12-20 (27.6 percent) drank alcohol in the past month, according to a survey by the Substance Abuse and Mental Health Services Administration. The study shows that the underage drinking rates were as high as 40 percent in some states such as North Dakota and Vermont.

27 Mar 2010

New scientific discoveries show that Canadian maple syrup can be good for health

The Federation of Quebec Maple Syrup Producers is pleased to report on two new scientific discoveries which show that Canadian maple syrup can be good for you. These studies build on recent findings on the nutritional value of maple products, which have revealed both the antioxidant properties of maple syrup as well as the discovery of substantial quantities of abscisic acid.

27 Mar 2010

Study: Automatic reporting of estimated GFR may result in unnecessary referrals by physicians

With a concern that the automatic reporting of estimated glomerular filtration rate (the flow rate of filtered fluid through the kidney, which is used to define the stage and severity of chronic kidney disease) may result in unnecessary referrals by physicians, new research indicates that automated laboratory reporting was associated with a significant increase in first-time visits to a kidney specialist, particularly among those at increased risk of late detection of kidney disease (such as older or female patients), according to a study in the March 24/31 issue of JAMA.

27 Mar 2010

Early stopping of clinical trials result in misleading estimates of treatment effects: Study

An international study of nearly 100 clinical trials that were stopped early due to positive treatment effects has found that many of those effects were exaggerated. The authors of the study — published in the current issue of the Journal of the American Medical Association — recommend that researchers resist pressures to end clinical trials early and continue trials for longer periods before even considering premature termination.

27 Mar 2010

Young adults increasingly flocking to EDs for medical treatment

Young adults, a generally healthy population, are increasingly flocking to emergency departments instead of outpatient clinics for medical treatment. Young adults remain the most likely age group to lack health insurance and often lose their insurance during this pivotal transition period between adolescence and adulthood.

27 Mar 2010

Study finds association between socioeconomic position and risk of death

An analysis of nearly 25 years of data for about 10,000 civil servants in London finds an association between socioeconomic position and risk of death, with much of this relation accounted for by health behaviors such as smoking, alcohol consumption, diet and physical activity, according to a study in the March 24/31 issue of JAMA.

27 Mar 2010

Thermo Fisher Scientific, Eli Lilly expand clinical trial materials supply chain relationship

Thermo Fisher Scientific Inc., the world leader in serving science, and biopharmaceutical company Eli Lilly and Company, announced today that they have expanded their clinical trial materials supply chain relationship. As part of a new five-year agreement, the Fisher Clinical Services business of Thermo Fisher will take over responsibility for Lilly’s in-house clinical trial materials manufacturing, packaging and labeling operations on-site at the Lilly Technology Center – North in Indianapolis. This transition is expected to be completed in the summer of 2010.

From Thermo Fisher Scientific Inc. 27 Mar 2010

Medical Research News

FT and GGT enzymes can be promising targets for treatment of lung cancer

Addiction to high calorie fat rich food: likened to cocaine and heroin addiction

Wave of violence and turmoil in Iraq lead to deterioration of linear growth of children

Bioethical issues and professionalism analyzed through two medical dramas

Child-patient research subjects too often in the dark about their participation: Study

Minority children in the U.S. face pervasive gap in quality and extent of health care

Diagnostic test for alcohol consumption: Measuring protein changes in blood

Study provides new clues to obesity epidemic

People with diabetes who undergo cancer surgery have greater risk of death: Study

ER stress response is major driver of insulin resistance, say researchers

TB-causing bacteria can hijack fat metabolism to drive progression of the disease

New approach may circumvent lost response in insulin due to obesity

UCSF approach may one day be used to create new periods of plasticity in human brain

SAMHSA survey: Underage drinking rates reach more than 27.6% in the past month

New scientific discoveries show that Canadian maple syrup can be good for health

Study: Automatic reporting of estimated GFR may result in unnecessary referrals by physicians

Early stopping of clinical trials result in misleading estimates of treatment effects: Study

Young adults increasingly flocking to EDs for medical treatment

Study finds association between socioeconomic position and risk of death

Thermo Fisher Scientific, Eli Lilly expand clinical trial materials supply chain relationship

How can microdialysis benefit drug development

Global and Local Efforts to Take Action Against Hepatitis

Addressing Important Cardiac Biology Questions with Shotgun Top-Down Proteomics

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