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New discovery can develop diagnostic test to identify gene mutation in AML

Decoding the DNA of a woman who died of acute myeloid leukemia (AML) has led researchers at Washington University School of Medicine in St. Louis to a gene that they found to be commonly altered in many patients who died quickly of the disease.

11 Nov 2010

Study on zebrafish showcases neural basis of essential survival skill

A tiny, translucent juvenile zebrafish, on the hunt for even littler prey, has offered up a big insight into how a specific circuit of nerve cells functions in the brain. The technique used to illuminate this circuitry, and the fish model itself, provide one of the first insights into the way individual sets of neurons control a specific behavior.

11 Nov 2010

SuperGen discontinues clinical development of SGI-1776 PIM kinase drug candidate

SuperGen, Inc. today announced that it has discontinued clinical development of its phase 1 PIM kinase drug candidate, SGI-1776, while continuing development of the PIM inhibitor program.

11 Nov 2010

Infant foods must be protected against fumonisin toxin

An international team of scientists calls for protecting complementary food for infants in developing countries - especially those where corn is a staple food - against fumonisin, a toxin produced by fungi. Until now, physicians thought the growth retardation of children in those regions was to be blamed on the poor nutritional value of the complementary maize porridge they receive when breast milk is no longer sufficient. But toxins indeed are involved, the scientists report in the journal Molecular Nutrition and Food Research.

10 Nov 2010

Chocolates inhibit enzyme known to raise blood pressure

Numerous studies have shown that cocoa has a protective effect against cardiovascular diseases. The reason for this has now been uncovered by researchers at Linköping University in Sweden. When a group of volunteers devoured a good-sized piece of dark chocolate, it inhibited an enzyme in their bodies that is known to raise blood pressure.

10 Nov 2010

Antigen Express awarded Therapeutic Discovery Project grants for cancer vaccine development

Generex Biotechnology Corporationannounced today that its wholly-owned immunotherapeutics subsidiary, Antigen Express, Inc. has been awarded two Therapeutic Discovery Project grants, totaling $488,958.50, by the United States Internal Revenue Service (IRS) and the Department of Health and Human Services (HHS) pursuant to the Patient Protection and Affordable Care Act of 2010.

10 Nov 2010

Simple test and an MRI predicts future Alzheimer’s disease

Until now is has been believed that Alzheimer’s disease and other forms of dementia could be diagnosed only when symptoms appear which almost always means when patients are in their 70s or 80s. Now the latest research shows that some brain lesions are characteristic of Alzheimer’s disease and can be detected in the brains of healthy people in their 40s. Along with this a simple mental skills test may be able to detect the problem many years sooner than previously thought.

10 Nov 2010

Statins benefit ‘at risk’ patients but are underused: Study

A look at some of the large clinical trials and studies has shown that thousands of deaths could be prevented a year if people at risk of heart attack or stroke are prescribed high doses of statins. The review involves data from 170,000 patients in 26 randomized trials. The paper is published in the journal The Lancet.

10 Nov 2010

Lung cancer in smokers versus non-smokers shows different genetic mutations

A group of scientists at B.C. Cancer Agency have found that lung cancers in smokers have different genetic mutations and look different than lung cancer in non-smokers. According to senior scientist at the BC Cancer Agency Research Centre Wan Lam, this finding is significant because it means that from now on, research, treatments and diagnostics should be tailored to the distinct genetic variations in the different lung cancers instead of expecting that a one-size fits all approach will work. He said, “At the current time, treatment does not distinguish between these different types. The subtypes are all grouped together. But with this work, we are beginning to tease out the subtypes.” The study was presented Tuesday at a conference in Philadelphia of the American Association of Cancer Research.

10 Nov 2010

Obese teens become obese adults

A new report shows that obese adolescent Americans tend to carry their extra weight into adulthood. The nationally representative study of American youth showed that one in 12 teenagers became severely obese as they entered adulthood with some 100 pounds above their ideal weight. And nearly half the girls and more than a third of the boys who are obese as teenagers grew up to be obese adults with a high risk of developing heart disease, diabetes and certain types of cancers.

10 Nov 2010

Researchers identify molecular cascade that drives process of reconnection in adult brain after stroke

A stroke wreaks havoc in the brain, destroying its cells and the connections between them. Depending on its severity and location, a stroke can impact someone's life forever, affecting motor activity, speech, memories, and more.

10 Nov 2010

Omeros identifies orphan GPCR compound that potentiates tumor-killing activity of doxorubicin

Omeros Corporation, a biopharmaceutical company committed to discovering, developing and commercializing products focused on inflammation and disorders of the central nervous system, today announced that a compound identified by the Company as an antagonist of GPR87, an orphan GPCR recently unlocked for drug development by Omeros and linked to squamous cell carcinoma, potentiates the tumor-killing activity of doxorubicin (Adriamycin), a widely used chemotherapeutic agent.

10 Nov 2010

Study shows dogs attack children's face, eyes

As dog bites become an increasingly major public health concern, a new study shows that unsupervised children are most at risk for bites, that the culprits are usually family pets and if they bite once, they will bite again with the second attack often more brutal than the first.

10 Nov 2010

Receptive music therapy associated with reduced depressive symptoms

A Swedish study that appears in the current issue of Psychotherapy and Psychosomatics applies music therapy to the treatment of depression.

10 Nov 2010

Study finds no association between working in wafer fabrication cleanrooms, cancer mortality

An exhaustive, five-year epidemiological study conducted by researchers from Vanderbilt University covering more than 100,000 semiconductor industry workers found no association between overall cancer mortality and working in wafer fabrication cleanrooms, the Semiconductor Industry Association reported today.

10 Nov 2010

Hospitals need to work more to prevent heart attack deaths: Study

Door-to-balloon time has dropped dramatically as hospitals rush heart attack patients into treatment, but a five-year study released Monday shows quicker hospital care has not saved more lives.

10 Nov 2010

Covidien analysis finds lower incidence of GI adverse events with topical NSAIDs versus oral

Covidien, a leading global provider of healthcare products, announced the results of an analysis that will be presented at the American College of Rheumatology's Annual Scientific Meeting. A pooled analysis of safety data suggests that patients with knee osteoarthritis (OA) receiving the topical PENNSAID® (diclofenac sodium topical solution) 1.5% w/w had significantly fewer gastrointestinal (GI)-related adverse events than those receiving an oral non-steroidal anti-inflammatory drug (NSAID).

10 Nov 2010

EuroNanoMed funds 8 projects with €8 Million for transnational research projects in nanomedicine

EuroNanoMed, a European funding initiative under the ERA-Net scheme of the European Commission aimed at advancing transnational research in Nanomedicine, announced today the projects that will be funded following its 2nd joint transnational call for collaborative research projects. Eight projects, involving 46 partners from 10 countries will be funded with €8 Million provided by EuroNanoMed partners. The research projects were chosen from 33 applications involving 178 applicant groups from 19 EU member and associated states/regions.

10 Nov 2010

Low levels of growth hormone may contribute to growth defects in cystic fibrosis

A new study using a pig model of cystic fibrosis (CF) suggests that low levels of a growth promoting hormone at or before birth may contribute to growth defects in patients with CF.

10 Nov 2010

Fibroblast growth factor-2 stimulates periodontal regeneration: Study

It is well known that oral infection progressively destroys periodontal tissues and is the leading cause of tooth loss in adults. A major goal of periodontal treatment is regeneration of the tissues lost to periodontitis. Unfortunately, most current therapies cannot predictably promote repair of tooth-supporting defects. A variety of regenerative approaches have been used clinically using bone grafts and guiding tissue membranes with limited success.

10 Nov 2010

Medical Research News

New discovery can develop diagnostic test to identify gene mutation in AML

Study on zebrafish showcases neural basis of essential survival skill

SuperGen discontinues clinical development of SGI-1776 PIM kinase drug candidate

Infant foods must be protected against fumonisin toxin

Chocolates inhibit enzyme known to raise blood pressure

Antigen Express awarded Therapeutic Discovery Project grants for cancer vaccine development

Simple test and an MRI predicts future Alzheimer’s disease

Statins benefit ‘at risk’ patients but are underused: Study

Lung cancer in smokers versus non-smokers shows different genetic mutations

Obese teens become obese adults

Researchers identify molecular cascade that drives process of reconnection in adult brain after stroke

Omeros identifies orphan GPCR compound that potentiates tumor-killing activity of doxorubicin

Study shows dogs attack children's face, eyes

Receptive music therapy associated with reduced depressive symptoms

Study finds no association between working in wafer fabrication cleanrooms, cancer mortality

Hospitals need to work more to prevent heart attack deaths: Study

Covidien analysis finds lower incidence of GI adverse events with topical NSAIDs versus oral

EuroNanoMed funds 8 projects with €8 Million for transnational research projects in nanomedicine

Low levels of growth hormone may contribute to growth defects in cystic fibrosis

Fibroblast growth factor-2 stimulates periodontal regeneration: Study

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